سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Saberi-Karimian, Maryam, Asadiyan-Sohan, Parisa, Ghoflchi, Sahar, Ghasemi, Maryam, Ferns, Gordon A., Aghasizadeh, Malihe, Ghayour-Mobarhan, Majid. (1404). Impact of Crocin Supplementation on Serum level of Zinc, Coppe, and Magnesium levels in Individuals with Metabolic Syndrome. , 13(2), 1537-1544. doi: 10.22038/jctm.2025.80591.1483
Maryam Saberi-Karimian; Parisa Asadiyan-Sohan; Sahar Ghoflchi; Maryam Ghasemi; Gordon A. Ferns; Malihe Aghasizadeh; Majid Ghayour-Mobarhan. "Impact of Crocin Supplementation on Serum level of Zinc, Coppe, and Magnesium levels in Individuals with Metabolic Syndrome". , 13, 2, 1404, 1537-1544. doi: 10.22038/jctm.2025.80591.1483
Saberi-Karimian, Maryam, Asadiyan-Sohan, Parisa, Ghoflchi, Sahar, Ghasemi, Maryam, Ferns, Gordon A., Aghasizadeh, Malihe, Ghayour-Mobarhan, Majid. (1404). 'Impact of Crocin Supplementation on Serum level of Zinc, Coppe, and Magnesium levels in Individuals with Metabolic Syndrome', , 13(2), pp. 1537-1544. doi: 10.22038/jctm.2025.80591.1483
Saberi-Karimian, Maryam, Asadiyan-Sohan, Parisa, Ghoflchi, Sahar, Ghasemi, Maryam, Ferns, Gordon A., Aghasizadeh, Malihe, Ghayour-Mobarhan, Majid. Impact of Crocin Supplementation on Serum level of Zinc, Coppe, and Magnesium levels in Individuals with Metabolic Syndrome. , 1404; 13(2): 1537-1544. doi: 10.22038/jctm.2025.80591.1483

Impact of Crocin Supplementation on Serum level of Zinc, Coppe, and Magnesium levels in Individuals with Metabolic Syndrome

Journal of Cardio-Thoracic Medicine
مقاله 5، دوره 13، شماره 2، شهریور 2025، صفحه 1537-1544    اصل مقاله (1.24 M)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22038/jctm.2025.80591.1483
نویسندگان
Maryam Saberi-Karimian1؛ Parisa Asadiyan-Sohan2؛ Sahar Ghoflchi2؛ Maryam Ghasemi2؛ Gordon A. Ferns3؛ Malihe Aghasizadeh* 2، 4؛ Majid Ghayour-Mobarhan* 1
1International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
2Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
3Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, UK.
4Vascular and Endovascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
چکیده
Introduction and Objectives: Current evidence on the association between serum trace element levels and the development of Metabolic Syndrome (MetS) is limited and inconsistent. Recently, investigators have examined saffron supplementation that, which could increase serum trace elements in individuals with MetS. This paper will focus on determining the impact of crocin capsules on the effectiveness of serum Zn, Cu, and Mg in people diagnosed with MetS.
Methods: In this study, a double-blind clinical trial was a conducted, comprising 44 individuals with MetS aged18-70 years.  Patients were categorized into a treatment group receiving crocin capsules (1g/day) or a placebo group for a period of 30 days. Levels of serum Zn, Mg, and Cu were measured using an automated analysis system (Model BT3000, Nica Instruments Biotech, Rome, Italy) at the baseline and end of the study.
Results: Forty-four subjects completed the clinical trial. The investigation showed that baseline characteristics revealed no notable differences between the placebo and crocin groups (p > 0.05). According to our analysis, it was visibly apparent that there was an increase in serum Zinc levels following crocin supplementation for 30 days. Crocin supplementation had no significant effects on serum. Mg, Zn/Cu, or Cu concentrations.
Conclusion: Metabolic disorders can be modulated by increasing the supply of dietary compounds with antioxidant properties such as crocin.
کلیدواژه‌ها
Crocin؛ Copper؛ Magnesium؛ Metabolic syndrome؛ Zinc
مراجع
  1. Yeh WT, Weng LC. Epidemiology of metabolic syndrome in Asia. Asia Pacific journal of clinical nutrition. 2008;17:37-42.
  2. Zaribaf F, Falahi E, Barak F, Heidari M, Keshteli AH, Yazdannik A, et al. Fish consumption is inversely associated with the metabolic syndrome. European journal of clinical nutrition. 2014 Apr;68(4):474-80.
  3. Johnson RJ, Segal MS, Sautin Y, Nakagawa T, Feig DI, Kang DH, et al. Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease2. The American journal of clinical nutrition. 2007 Oct 1;86(4):899-906.
  4. Farmanfarma KK, Kaykhaei MA, Adineh HA, Mohammadi M, Dabiri S, Ansari-Moghaddam A. Prevalence of metabolic syndrome in Iran: A meta-analysis of 69 studies. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2019 Jan 1;13(1):792-9.
  5. Ma J, Zhou Y, Wang D, Guo Y, Wang B, Xu Y, et al. Associations between essential metals exposure and metabolic syndrome (MetS): exploring the mediating role of systemic inflammation in a general Chinese population. Environment international. 2020 Jul 1;140:105802.
  6. Milanino R, Marrella M, Gasperini R, Pasqualicchio M, Velo G. Copper and zinc body levels in inflammation: an overview of the data obtained from animal and human studies. Agents and actions. 1993 Jul;39:195-209.
  7. von Bülow V, Dubben S, Engelhardt G, Hebel S, Plümäkers B, Heine H, et al. Zinc-dependent suppression of TNF-α production is mediated by protein kinase A-induced inhibition of Raf-1, IκB kinase β, and NF-κB. The Journal of Immunology. 2007 Sep 15;179(6):4180-6.
  8. Hara T, Takeda TA, Takagishi T, Fukue K, Kambe T, Fukada T. Physiological roles of zinc transporters: molecular and genetic importance in zinc homeostasis. The Journal of Physiological Sciences. 2017 Mar 1;67(2):283-301.
  9. Olechnowicz J, Tinkov A, Skalny A, Suliburska J. Zinc status is associated with inflammation, oxidative stress, lipid, and glucose metabolism. The journal of physiological sciences. 2018 Jan 1;68(1):19-31.
  10.  Ghasemi A, Zahediasl S, Hosseini-Esfahani F, Azizi F. Gender differences in the relationship between serum zinc concentration and metabolic syndrome. Annals of human biology. 2014 Sep 1;41(5):436-42.
  11.  Rashidmayvan M, Mansoori A, Aghasizadeh M, Dianati M, Barati S, Sahranavard T, et al. Prediction of cardiovascular disease risk by serum zinc and copper concentrations and anthropometric measurements. Journal of Trace Elements in Medicine and Biology. 2024 May 1;83:127385.
  12. Uauy R, Olivares M, Gonzalez M. Essentiality of copper in humans. The American journal of clinical nutrition. 1998 May 1;67(5):952S-9S.
  13. Xu J, Zhou Q, Liu G, Tan Y, Cai L. Analysis of serum and urinal copper and zinc in Chinese northeast population with the prediabetes or diabetes with and without complications. Oxidative medicine and cellular longevity. 2013;2013(1):635214.
  14.  Freitas EP, Cunha AT, Aquino SL, Pedrosa LF, Lima SC, Lima JG, et al. Zinc status biomarkers and cardiometabolic risk factors in metabolic syndrome: a case control study. Nutrients. 2017 Feb 22;9(2):175.
  15.  Qu R, Jia Y, Liu J, Jin S, Han T, Na L. Dietary flavonoids, copper intake, and risk of metabolic syndrome in Chinese adults. Nutrients. 2018 Jul 29;10(8):991.
  16. La SA, Lee JY, Kim DH, Song EL, Park JH, Ju SY. Low magnesium levels in adults with metabolic syndrome: a meta-analysis. Biological trace element research. 2016 Mar;170:33-42.
  17.  Lu CW, Lee YC, Kuo CS, Chiang CH, Chang HH, Huang KC. Association of serum levels of zinc, copper, and iron with risk of metabolic syndrome. Nutrients. 2021 Feb 7;13(2):548.
  18. de Oliveira Otto MC, Alonso A, Lee DH, Delclos GL, Bertoni AG, et al. Dietary Intakes of Zinc and Heme Iron from Red Meat, but Not from Other Sources, Are Associated with Greater Risk of Metabolic Syndrome and Cardiovascular Disease3. The Journal of nutrition. 2012 Mar 1;142(3):526-33.
  19.  Ju SY, Choi WS, Ock SM, Kim CM, Kim DH. Dietary magnesium intake and metabolic syndrome in the adult population: dose-response meta-analysis and meta-regression. Nutrients. 2014 Dec 22;6(12):6005-19.
  20. Dibaba DT, Xun P, Fly AD, Yokota K, He K. Dietary magnesium intake and risk of metabolic syndrome: a meta‐analysis. Diabetic Medicine. 2014 Nov;31(11):1301-9.
  21. Choi MK, Bae YJ. Relationship between dietary magnesium, manganese, and copper and metabolic syndrome risk in Korean adults: the Korea National Health and Nutrition Examination Survey (2007–2008). Biological Trace Element Research. 2013 Dec;156:56-66.
  22. Noori N, Nafar M, Poorrezagholi F, Ahmadpoor P, Samadian F, Firouzan A, et al. Dietary intakes of fiber and magnesium and incidence of metabolic syndrome in first year after renal transplantation. Journal of Renal Nutrition. 2010 Mar 1;20(2):101-11.
  23. Maekawa M, Watanabe A, Iwayama Y, Kimura T, Hamazaki K, Balan S, et al. Polyunsaturated fatty acid deficiency during neurodevelopment in mice models the prodromal state of schizophrenia through epigenetic changes in nuclear receptor genes. Translational psychiatry. 2017 Sep;7(9):e1229-.
  24. Burns KA, Vanden Heuvel JP. Modulation of PPAR activity via phosphorylation. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids. 2007 Aug 1;1771(8):952-60.
  25. Ghoushi E, Poudineh M, Parsamanesh N, Jamialahmadi T, Sahebkar A. Curcumin as a regulator of Th17 cells: Unveiling the mechanisms. Food Chemistry: Molecular Sciences. 2024 Mar 12:100198.
  26. Li X, Jiang C, Zhu W. Crocin reduces the inflammation response in rheumatoid arthritis. Bioscience, biotechnology, and biochemistry. 2017 May 4;81(5):891-8.
  27. Hazman Ö, Aksoy L, Büyükben A. Effects of crocin on experimental obesity and type-2 diabetes. Turkish journal of medical sciences. 2016;46(5):1593-602.
  28. Shirali S, Zahra Bathaie S, Nakhjavani M. Effect of crocin on the insulin resistance and lipid profile of streptozotocin‐induced diabetic rats. Phytotherapy Research. 2013 Jul;27(7):1042-7.
  29. Rajaei Z, Hadjzadeh MA, Nemati H, Hosseini M, Ahmadi M, Shafiee S. Antihyperglycemic and antioxidant activity of crocin in streptozotocin-induced diabetic rats. Journal of medicinal food. 2013 Mar 1;16(3):206-10.
  30. Mohajer A, Ghayour-Mobarhan M, Parizadeh SM, Tavallaie S, Rajabian M, Sahebkar A. Effects of supplementation with curcuminoids on serum copper and zinc concentrations and superoxide dismutase enzyme activity in obese subjects. Trace Elem. Electrolytes. 2014;32:16-21.
  31. Javandoost A, Afshari A, Nikbakht-Jam I, Khademi M, Eslami S, Nosrati M, et al. Effect of crocin, a carotenoid from saffron, on plasma cholesteryl ester transfer protein and lipid profile in subjects with metabolic syndrome: A double blind randomized clinical trial. ARYA atherosclerosis. 2017 Sep;13(5):245.
  32. Mohammadi A, Sahebkar A, Iranshahi M, Amini M, Khojasteh R, Ghayour‐Mobarhan M, et al. Effects of supplementation with curcuminoids on dyslipidemia in obese patients: a randomized crossover trial. Phytotherapy Research. 2013 Mar;27(3):374-9.
  33. Nikbakht-Jam I, Khademi M, Nosrati M, Eslami S, Foroutan-Tanha M, Sahebkar A, et al. Effect of crocin extracted from saffron on pro-oxidant–anti-oxidant balance in subjects with metabolic syndrome: A randomized, placebo-controlled clinical trial. European journal of integrative medicine. 2016 Jun 1;8(3):307-12.
  34. Yan X, Zhao S, Feng X, Li X, Zhou Q, Chen Q. Effects of Crocus sativus on glycemic control and cardiometabolic parameters among patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials. Nutrition & Metabolism. 2024 May 25;21(1):28.
  35. Alavizadeh SH, Hosseinzadeh H. Bioactivity assessment and toxicity of crocin: a comprehensive review. Food and chemical toxicology. 2014 Feb 1;64:65-80.
  36. Goli SA, Mokhtari F, Rahimmalek M. Phenolic compounds and antioxidant activity from saffron (Crocus sativus L.) petal. Journal of Agricultural Science. 2012;4(10):175-.
  37. Kermani T, Kazemi T, Molki S, Ilkhani K, Sharifzadeh G, Rajabi O. The efficacy of crocin of saffron (Crocus sativus L.) on the components of metabolic syndrome: A randomized controlled clinical trial. Journal of research in pharmacy practice. 2017 Oct 1;6(4):228-32.
  38. Vallee BL, Falchuk KH. The biochemical basis of zinc physiology. Physiological reviews. 1993 Jan 1;73(1):79-118.
  39. Prasad AS. Zinc: role in immunity, oxidative stress and chronic inflammation. Current Opinion in Clinical Nutrition & Metabolic Care. 2009 Nov 1;12(6):646-52.
  40. Hamasaki H, Kawashima Y, Yanai H. Serum Zn/Cu ratio is associated with renal function, glycemic control, and metabolic parameters in Japanese patients with and without type 2 diabetes: a cross-sectional study. Frontiers in endocrinology. 2016 Nov 15;7:147.
  41. Miao X, Sun W, Fu Y, Miao L, Cai L. Zinc homeostasis in the metabolic syndrome and diabetes. Frontiers of medicine. 2013 Mar;7:31-52.
  42. Viktorínová A, Tošerová E, Križko M, Ďuračková Z. Altered metabolism of copper, zinc, and magnesium is associated with increased levels of glycated hemoglobin in patients with diabetes mellitus. Metabolism. 2009 Oct 1;58(10):1477-82.
  43. Seo JA, Song SW, Han K, Lee KJ, Kim HN. The associations between serum zinc levels and metabolic syndrome in the Korean population: findings from the 2010 Korean National Health and Nutrition Examination Survey. PloS one. 2014 Aug 25;9(8):e105990.
  44. Yu Y, Cai Z, Zheng J, Chen J, Zhang X, Huang XF, et al. Serum levels of polyunsaturated fatty acids are low in Chinese men with metabolic syndrome, whereas serum levels of saturated fatty acids, zinc, and magnesium are high. Nutrition research. 2012 Feb 1;32(2):71-7.
  45. Mohamadian M, Parsamanesh N, Chiti H, Sathyapalan T, Sahebkar A. Protective effects of curcumin on ischemia/reperfusion injury. Phytotherapy Research. 2022 Dec;36(12):4299-324.
  46. Guerrero-Romero F, Jaquez-Chairez FO, Rodríguez-Morán M. Magnesium in metabolic syndrome: a review based on randomized, double-blind clinical trials. Magnesium research. 2016 Dec 1;29(4).
  47. Yang HK, Lee SH, Han K, Kang B, Lee SY, Yoon KH, et al. Lower serum zinc levels are associated with unhealthy metabolic status in normal-weight adults: the 2010 Korea National Health and Nutrition Examination Survey. Diabetes & metabolism. 2015 Sep 1;41(4):282-90.
  48. Darroudi S, Fereydouni N, Tayefi M, Esmaily H, Sadabadi F, Khashyarmanesh Z, et al. Altered serum Zinc and Copper in Iranian Adults who were of normal weight but metabolically obese. Scientific Reports. 2019 Oct 16;9(1):14874.
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