Silver-hollow mesoporous silica nanoparticles for clarithromycin delivery in an animal model of helicobacter pylori | ||
| Nanomedicine Journal | ||
| دوره 12، شماره 3، پاییز 2025، صفحه 433-442 اصل مقاله (1.31 M) | ||
| نوع مقاله: Research Paper | ||
| شناسه دیجیتال (DOI): 10.22038/nmj.2025.81213.2011 | ||
| نویسندگان | ||
| Soroush Mirfakhraee1؛ Reza Mirnejad2؛ Maryam Iman* 3 | ||
| 1Student Research Committee, Baqiyatallah University of Medical Sciences, Tehran, Iran | ||
| 2Molecular Biology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran | ||
| 3Department of Pharmaceutics, Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran | ||
| چکیده | ||
| Background: Nanoparticle-based drug delivery systems offer a promising approach to overcoming antimicrobial resistance and enhancing therapeutic efficacy. Objective(s): This study aimed to evaluate the efficacy of silver-hollow mesoporous silica nanoparticles (Ag-HMSNs) in the targeted delivery of clarithromycin for eradicating Helicobacter pylori (H. pylori). Materials and Methods: A synergistic formulation comprising silver nanoparticles and clarithromycin-loaded hollow mesoporous silica nanoparticles (Ag-HMSNs@CLT) was examined for its antibacterial activity against H. pylori. The effectiveness of various anti-H. pylori formulations was determined using in vitro inhibition assays and in vivo bacterial load reduction studies. Results: The hollow mesoporous silica nanoparticles (HMSNs) demonstrated a high drug-loading capacity, with a clarithromycin content of 27%. The minimum inhibitory concentrations (MIC) for silver nanoparticles (Ag NPs), clarithromycin (CLT), and Ag-HMSNs@CLT were <2 μg/mL, <0.5 μg/mL, and <0.25 μg/mL, respectively. Among the tested formulations, Ag-HMSNs@CLT exhibited the most pronounced reduction in bacterial load during in vivo studies and significantly mitigated inflammation, as evidenced by hematoxylin-eosin staining. Conclusion: The developed nanoparticle-based drug delivery system exhibited excellent drug-loading efficiency and controlled drug release over an extended period. This study highlighted the potential synergistic effects of combining anti-H. pylori agents and their efficacy in reducing bacterial growth and alleviating gastrointestinal complications associated with H. pylori infection. | ||
| کلیدواژهها | ||
| Drug liberation؛ Drug delivery systems؛ Helicobacter pylori؛ Mesoporous silica nanoparticles | ||
| مراجع | ||
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