سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Eraslan, Ersen, Tanyeli̇, Ayhan, Guler, Mustafa, Eki̇nci̇ Akdemi̇r, Fazile Nur, Topdaği, Ömer, Yazici, Şahin, Güzel Erdoğan, Derya, Çinar Tanriverdi̇, Esra, Çomakli, Selim. (1404). Therapeutic potential of casticin in alleviating ovarian torsion/detorsion-induced ovarian and lung injuries. , 28(8), 1057-1064. doi: 10.22038/ijbms.2025.85990.18572
Ersen Eraslan; Ayhan Tanyeli̇; Mustafa Can Guler; Fazile Nur Eki̇nci̇ Akdemi̇r; Ömer Topdaği; Şahin Yazici; Derya Güzel Erdoğan; Esra Çinar Tanriverdi̇; Selim Çomakli. "Therapeutic potential of casticin in alleviating ovarian torsion/detorsion-induced ovarian and lung injuries". , 28, 8, 1404, 1057-1064. doi: 10.22038/ijbms.2025.85990.18572
Eraslan, Ersen, Tanyeli̇, Ayhan, Guler, Mustafa, Eki̇nci̇ Akdemi̇r, Fazile Nur, Topdaği, Ömer, Yazici, Şahin, Güzel Erdoğan, Derya, Çinar Tanriverdi̇, Esra, Çomakli, Selim. (1404). 'Therapeutic potential of casticin in alleviating ovarian torsion/detorsion-induced ovarian and lung injuries', , 28(8), pp. 1057-1064. doi: 10.22038/ijbms.2025.85990.18572
Eraslan, Ersen, Tanyeli̇, Ayhan, Guler, Mustafa, Eki̇nci̇ Akdemi̇r, Fazile Nur, Topdaği, Ömer, Yazici, Şahin, Güzel Erdoğan, Derya, Çinar Tanriverdi̇, Esra, Çomakli, Selim. Therapeutic potential of casticin in alleviating ovarian torsion/detorsion-induced ovarian and lung injuries. , 1404; 28(8): 1057-1064. doi: 10.22038/ijbms.2025.85990.18572

Therapeutic potential of casticin in alleviating ovarian torsion/detorsion-induced ovarian and lung injuries

Iranian Journal of Basic Medical Sciences
مقاله 9، دوره 28، شماره 8، آبان 2025، صفحه 1057-1064    اصل مقاله (978.32 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2025.85990.18572
نویسندگان
Ersen Eraslan1؛ Ayhan Tanyeli̇2؛ Mustafa Can Guler* 2؛ Fazile Nur Eki̇nci̇ Akdemi̇r3؛ Ömer Topdaği4؛ Şahin Yazici5؛ Derya Güzel Erdoğan6؛ Esra Çinar Tanriverdi̇7؛ Selim Çomakli8
1Department of Physiology, Faculty of Medicine, Bandırma Onyedi Eylül University, Bandırma, Turkey
2Department of Physiology, Faculty of Medicine, Atatürk University, Erzurum, Turkey
3Department of Nutrition and Dietetics, Faculty of Health Science, Ağrı İbrahim Çeçen University, Ağrı, Turkey
4Department of Internal Medicine, Faculty of Medicine, Bahçeşehir University, Istanbul, Turkey
5Department of Obstetrics and Gynecology, Erzurum City Hospital, Erzurum, Turkey
6Department of Physiology, Faculty of Medicine, Sakarya University, Sakarya, Turkey
7Department of Medicine Education, Atatürk University, Erzurum, Turkey
8Department of Pathology, Faculty of Veterinary Medicine, Atatürk University, Erzurum, Turkey
چکیده
Objective(s): Ovarian torsion is a critical gynecological emergency caused by the twisting of the ovary around its supporting structures, resulting in compromised blood flow and potential ovarian damage. Ovarian torsion/detorsion (T/D) can lead to severe complications, including infertility, if not promptly addressed. This study aimed to investigate the therapeutic effects of casticin (CAST) on ovarian and lung tissue injuries induced by a bilateral ovarian T/D model in rats.
Materials and Methods: Experimental animals were randomly allocated into groups of sham, T/D, CAST 5 mg/kg, and CAST 10 mg/kg. Ovarian and lung tissues were subjected to biochemical, histopathological, and immunohistochemical analyses.
Results: In the T/D group, markers of oxidative stress and inflammation, including myeloperoxidase (MPO) activity, malondialdehyde (MDA), oxidative stress index (OSI), tumor necrosis factor-alpha (TNF-α), and 8-hydroxy-2’ deoxyguanosine (8-OHdG), were significantly elevated (P<0.05). Conversely, superoxide dismutase (SOD) activity and total antioxidant status (TAS) levels were notably decreased (P<0.05). CAST administration significantly attenuated tissue damage by reducing oxidative stress and inflammatory markers while enhancing antioxidant defense (P<0.05).
Conclusion: CAST demonstrated a therapeutic effect against ovarian and lung tissue damage induced by T/D, suggesting that it may serve as a potential therapeutic agent for treating ovarian T/D-related injuries. These findings underscore the potential of CAST in clinical settings, particularly as a novel intervention to mitigate complications associated with I/R injuries in gynecological emergencies.
کلیدواژه‌ها
Casticin؛ Torsion Detorsion؛ Ovary؛ Lung؛ Rat
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