Vakili, Nima, Asefnejad, Azadeh, Mohammadi, Mohammad, Rezaei, Hessam, Khandan, Amirsalar. (1404). Improving physicochemical, mechanical, and biological properties of a porous polyvinyl alcohol/chitosan matrix via modification with magnesium and silicon agents. , 12(3), 507-517. doi: 10.22038/nmj.2025.79321.1951
Nima Vakili; Azadeh Asefnejad; Mohammad Mohammadi; Hessam Rezaei; Amirsalar Khandan. "Improving physicochemical, mechanical, and biological properties of a porous polyvinyl alcohol/chitosan matrix via modification with magnesium and silicon agents". , 12, 3, 1404, 507-517. doi: 10.22038/nmj.2025.79321.1951
Vakili, Nima, Asefnejad, Azadeh, Mohammadi, Mohammad, Rezaei, Hessam, Khandan, Amirsalar. (1404). 'Improving physicochemical, mechanical, and biological properties of a porous polyvinyl alcohol/chitosan matrix via modification with magnesium and silicon agents', , 12(3), pp. 507-517. doi: 10.22038/nmj.2025.79321.1951
Vakili, Nima, Asefnejad, Azadeh, Mohammadi, Mohammad, Rezaei, Hessam, Khandan, Amirsalar. Improving physicochemical, mechanical, and biological properties of a porous polyvinyl alcohol/chitosan matrix via modification with magnesium and silicon agents. , 1404; 12(3): 507-517. doi: 10.22038/nmj.2025.79321.1951

Improving physicochemical, mechanical, and biological properties of a porous polyvinyl alcohol/chitosan matrix via modification with magnesium and silicon agents

Nanomedicine Journal
دوره 12، شماره 3، پاییز 2025، صفحه 507-517    اصل مقاله (919.05 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22038/nmj.2025.79321.1951
نویسندگان
Nima Vakili1؛ Azadeh Asefnejad* 1؛ Mohammad Mohammadi1؛ Hessam Rezaei1؛ Amirsalar Khandan2
1Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
2Dental Research Center, Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
چکیده
Objective(s): Biocomposite scaffolds made from polymers and bioactive materials can provide the necessary bioactivity and mechanical properties for bone tissue engineering.
Materials and Methods: In this study, we aimed to evaluate the properties of a novel composite scaffold made from a combination of chitosan, PVA, MgCl₂, and GPTMS as a crosslinking agent. Scanning Electron Microscopy (SEM) and Fourier-Transform Infrared Spectroscopy (FTIR) analysis characterized the prepared composite scaffold. The composite scaffolds' mechanical properties, bioactivity, biocompatibility, swelling, and degradation were also investigated.
Results: Significant improvements in the mechanical properties were observed in the modified composite compared to those seen in the scaffold without MgCl₂. With an increase in MgCl₂ content, the scaffold's degradation and porosity increased, while its swelling capacity decreased. Bioactivity was also enhanced in the composite following the further addition of MgCl₂.
Conclusion:  In vitro tests for cytotoxicity and MG-63 cell proliferation showed that the composite scaffolds were non-cytotoxic, resulting in better cell adherence and growth on the surface of these scaffolds.  
کلیدواژه‌ها
PVA-chitosan Scaffolds؛ Magnesium chloride؛ GPTMS؛ Osseoinductivity؛ Dental materials
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