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Kandukoori, Naga Raju, Jhansi, Kethavath, B, Deepika, Ratnam Devadasu, Venkat, Venu Madhav, Katla. (1404). Enhancement of buoyant properties of gastroretentive dosage forms through nanosponge-based formulations. , 12(3), 500-506. doi: 10.22038/nmj.2025.86211.2166
Naga Raju Kandukoori; Kethavath Jhansi; Deepika B; Venkat Ratnam Devadasu; Katla Venu Madhav. "Enhancement of buoyant properties of gastroretentive dosage forms through nanosponge-based formulations". , 12, 3, 1404, 500-506. doi: 10.22038/nmj.2025.86211.2166
Kandukoori, Naga Raju, Jhansi, Kethavath, B, Deepika, Ratnam Devadasu, Venkat, Venu Madhav, Katla. (1404). 'Enhancement of buoyant properties of gastroretentive dosage forms through nanosponge-based formulations', , 12(3), pp. 500-506. doi: 10.22038/nmj.2025.86211.2166
Kandukoori, Naga Raju, Jhansi, Kethavath, B, Deepika, Ratnam Devadasu, Venkat, Venu Madhav, Katla. Enhancement of buoyant properties of gastroretentive dosage forms through nanosponge-based formulations. , 1404; 12(3): 500-506. doi: 10.22038/nmj.2025.86211.2166

Enhancement of buoyant properties of gastroretentive dosage forms through nanosponge-based formulations

Nanomedicine Journal
دوره 12، شماره 3، مهر 2025، صفحه 500-506    اصل مقاله (1.05 M)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22038/nmj.2025.86211.2166
نویسندگان
Naga Raju Kandukoori* ؛ Kethavath Jhansi؛ Deepika B؛ Venkat Ratnam Devadasu؛ Katla Venu Madhav
Department of Pharmaceutics, St. Pauls College of Pharmacy, Hyderabad, Telangana, India.
چکیده
Objective(s): This study aimed to develop floating tablets of an insoluble weak acidic drug. The study protocol objective was to prepare the tablets using two forms of active pharmaceutical ingredient (API): the pure form and the modified nanosponge form.
Materials and Methods: Lamotrigine was used as API and other ingredients used were HPMC, Xanthan gum, Magnesium stearate etc. The physicochemical properties of all the prepared tablets were tested, and the results were found to comply with the standards. Gastroretentive (GR) characteristics, such as floating lag time and duration, were recorded and compared.
Results: The formulations containing the pure form of the drug (F1 to F4) exhibited longer floating lag times and shorter floating durations, whereas the tablets containing the nanosponge form of the drug (F5 to F8) showed improved buoyant properties, evidenced by shorter lag times and longer floating durations. All formulations were evaluated for in-vitro drug release, with a higher percentage of drug dissolution observed in the nanosponge-based formulations.
Conclusion: These results highlight the importance of modifying the physical form of an insoluble drug to enhance both buoyancy and drug release properties in gastroretentive tablet dosage forms.
کلیدواژه‌ها
Floatation؛ Gastric residence؛ Lamotrigine؛ Sponge meshes؛ Xanthan gum
مراجع
  1. Gloria MC, Juan DR, Achmad H, Monica MJ, Isidoro C. Current trends in 3D printed gastroretentive floating drug delivery systems: a comprehensive review. IntJ Pharm. 2024; 663: 1-20.
  2. Naga LC, Ganga BM, Krishna PV, Swathi K, Naga RK, Eswaraiah MC. Floating drug delivery approaches for prolonged gastric retention. Res J Pharm Tech. 2013; 6(7): 706-710.
  3. Akash G, Wen-Cheng L, Himansu C, Rutvi A, Talever S, Ramkumar C, et al. Nanosponge: a promising and intriguing strategy in medical and pharmaceutical science. Heliyon. 2024; 10: 1-19.
  4. Sunil K, Babu LJ, Rekha R. A new perspective of psoriasis: dithranol nanosponge loaded hydrogels. Appl Surf Sci Adv. 2022; 12: 1-9.
  5. Olivia S, Sreejan M, Gouranga N, Subrata J, Sougata J. Recent advances in alginate based gastroretentive technologies for drug delivery applications. Med Nov Technol Devices. 2023; 18: 1-12.
  6. Mohammed J, Mohd SA, Mohammed S, Saira Z, Hanan MH, Layali IA, et al. Development of apigenin loaded gastroretentive microsponge for the targeting of Helecobacter pylori. Saudi Pharm J. 2023; 31: 659-668.
  7. Ashish YP, Khanderao RJ, Sharayu PR, Ashwini SS, Milind JU. Formulation and evaluation of nanosponges loaded hydrogel of Metformin hydrochloride. Indian J Pharm Educ Res. 2023; 57(1): 53-61.
  8. Dalia AG, Mahasen AR, Danah AA, Jenan AA, Rafa SA, Reema MA, et al. Formulation and evaluation of Piroxicam nanosponge for improved internal solubility and analgesic activity. Drug Deliv. 2023; 30(1): 1-10.
  9. Cassiana M, Gabriela CM, Clarissa GB, Jamil A, Marcos AS, Gilles P. Cyclodextrin based nanosponge of norfloxacin: intestinal permeation enhancement and improved antibacterial activity. Carbohydr Polym. 2018; 195: 586-592.
  10. Naga RK, Fasiha M, Ravali K, Syeda WJ, Deepika B, Narsimha RY. Studies on influence of polypropylene foam powder on gastroretentive properties of floating tablets of Cefditoren pivoxil. Res J Pharm Tech. 2018; 11(9): 3923-3926.
  11. Adane Y, Chernet T, Zewdu Y, Solomon A. Formulation and in-vitro evaluation of Furosemide floating matrix tablets using Boswellia papyrifera resin as matrix forming polymer. Biomed Res Int. 2023; 1-11.
  12. Latha K, Kishore C, Naseeb BS, Shailaja T. Formulation and evaluation of sintered floating tablets of Cefpodoxime proxetil. Turk J Pharm Sci. 2018; 15(3): 278-290.
آمار
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