Association between flavonoid intake and arterial stiffness: PERSIAN cohort study | ||
| Avicenna Journal of Phytomedicine | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 03 اردیبهشت 1404 اصل مقاله (725.78 K) | ||
| نوع مقاله: Short communication | ||
| شناسه دیجیتال (DOI): 10.22038/ajp.2025.25958 | ||
| نویسندگان | ||
| Sara Ghodrat1؛ Mostafa shahraki jazinaki1؛ Reza Rezvani1؛ Majid Khadem Rezaiyan2؛ Seyyed Mostafa Arabi3؛ Saeid Eslami4؛ MohammadHassan Abolhasani5؛ Seyed Mohammad Tabatabaee Jabali6؛ Abdolreza Norouzy* 1، 5 | ||
| 1Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 2Department of Community Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 3Clinical nutrition and biochemistry department, Faculty of Medicine, Neyashbur University of Medical Sciences, Neyshabur, Iran. | ||
| 4Department of Medical Informatics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 5Department of Clinical Nutrition, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran | ||
| 6Department of Sports Medicine, School of Medicine, Iran University of Medical Sciences, Tehran, Iran | ||
| چکیده | ||
| Objective: Given the growing prevalence of cardiovascular diseases (CVDs), preventing them is considered one of the most critical global health goals. Evidence suggests that high flavonoid intake may reduce the risk of CVDs. Therefore, this study investigates the association between flavonoid intake and arterial stiffness as a predictor of CVDs. Materials and Methods: The PERSIAN cohort study in Mashhad data was used in this cross-sectional study. From data registered in the cohort center, 3423 men and women aged 35 to 70 years were recruited for this study. Total flavonoid intake and intakes of each flavonoid subclass were obtained through a food frequency questionnaire using the Phenol Explorer. Then, their association with blood pressure and arterial stiffness indices, including pulse wave velocity (PWV) and central augmentation index (AIx), was assessed using univariate logistic regression, and confounding factors were adjusted by performing the multivariable analysis. Results: The findings showed that total flavonoid intake had a non-significant inverse relationship with high-risk levels of PWV and AIx (OR (95% CI) for the highest quintile compared to the lowest quintile were 0.83 (0.65-1.06) and 0.95 (0.74-1.21), respectively). Also, no significant association was detected between intake of each flavonoid subclass and high-risk levels of blood pressure or arterial stiffness indices including PWV and AIx. Conclusion: This study revealed that total flavonoid and each flavonoid subclass had no significant association with high-risk arterial stiffness or blood pressure levels. More studies on flavonoids' impact on arterial stiffness are needed for a definite conclusion | ||
| کلیدواژهها | ||
| Flavonoids؛ Polyphenols؛ Arterial stiffness؛ Pulse wave velocity؛ Cardiovascular diseases | ||
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