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Sheikhi, Vahid, Neamatshahi, Mahboubeh, Fouji, Parisa, Miri, Aghil, Keykhosravi, Aghil. (1403). Assessing the Correlation between Acid-Base Parameters, BUN/Creatinine Ratio, and eGFR in Children Aged 2–18 Years Hospitalized with Diabetic Ketoacidosis: A Retrospective Study at Heshmatieh Hospital, Sabzevar (2016–2022). , 13(3), 19377-19382. doi: 10.22038/jpp.2025.86846.5532
Vahid Sheikhi; Mahboubeh Neamatshahi; Parisa Fouji; Aghil Miri; Aghil Keykhosravi. "Assessing the Correlation between Acid-Base Parameters, BUN/Creatinine Ratio, and eGFR in Children Aged 2–18 Years Hospitalized with Diabetic Ketoacidosis: A Retrospective Study at Heshmatieh Hospital, Sabzevar (2016–2022)". , 13, 3, 1403, 19377-19382. doi: 10.22038/jpp.2025.86846.5532
Sheikhi, Vahid, Neamatshahi, Mahboubeh, Fouji, Parisa, Miri, Aghil, Keykhosravi, Aghil. (1403). 'Assessing the Correlation between Acid-Base Parameters, BUN/Creatinine Ratio, and eGFR in Children Aged 2–18 Years Hospitalized with Diabetic Ketoacidosis: A Retrospective Study at Heshmatieh Hospital, Sabzevar (2016–2022)', , 13(3), pp. 19377-19382. doi: 10.22038/jpp.2025.86846.5532
Sheikhi, Vahid, Neamatshahi, Mahboubeh, Fouji, Parisa, Miri, Aghil, Keykhosravi, Aghil. Assessing the Correlation between Acid-Base Parameters, BUN/Creatinine Ratio, and eGFR in Children Aged 2–18 Years Hospitalized with Diabetic Ketoacidosis: A Retrospective Study at Heshmatieh Hospital, Sabzevar (2016–2022). , 1403; 13(3): 19377-19382. doi: 10.22038/jpp.2025.86846.5532

Assessing the Correlation between Acid-Base Parameters, BUN/Creatinine Ratio, and eGFR in Children Aged 2–18 Years Hospitalized with Diabetic Ketoacidosis: A Retrospective Study at Heshmatieh Hospital, Sabzevar (2016–2022)

Journal of Pediatric Perspectives
مقاله 5، دوره 13، شماره 3، خرداد 2025، صفحه 19377-19382    اصل مقاله (472.83 K)
نوع مقاله: original article
شناسه دیجیتال (DOI): 10.22038/jpp.2025.86846.5532
نویسندگان
Vahid Sheikhi1؛ Mahboubeh Neamatshahi2؛ Parisa Fouji3؛ Aghil Miri4؛ Aghil Keykhosravi* 5
1Assistant Professor, Department of Pediatric Nephrology, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
2Assistant Professor, Department of Community Medicine, Faculty of Medicine, Sabzevar University of Medical Sciences, Khorasan Razavi, Iran.
3Student of Medical Science, Zahedan University of Medical Sciences, Zahedan, Iran.
4Assistant Professor, Department of Pediatric Medicine, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
5Assistant Professor, Department of Pediatric Nephrology, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Khorasan Razavi, Iran.
چکیده
Background: Diabetic Ketoacidosis (DKA) is a life-threatening complication of diabetes mellitus, particularly prevalent in pediatric populations. This study aims to explore the correlation between blood gas parameters, serum blood urea nitrogen (BUN)/creatinine (Cr) ratio, and estimated glomerular filtration rate (eGFR) in pediatric patients aged 2 to 18 years hospitalized with DKA at Heshmatieh Hospital in Sabzevar between 2016 and 2022.
Methods: In this retrospective study, 84 patients diagnosed with diabetic ketoacidosis (DKA) were included. Arterial blood gas analysis was performed to assess pH, bicarbonate (HCO₃⁻), and anion gap levels, which are key parameters for evaluating DKA severity and guiding clinical management. Renal function was evaluated using the blood urea nitrogen-to-creatinine ratio (BUN/Cr) and estimated glomerular filtration rate (eGFR), as dehydration and metabolic disturbances during DKA may acutely impair kidney function. These laboratory markers were analyzed to explore their utility in monitoring both metabolic and renal status throughout the treatment course.
Results: This investigation evaluates the interplay between these parameters to identify potential biomarkers for assessing DKA severity and predicting clinical outcomes. Preliminary findings suggest that abnormal blood gas values, elevated BUN/Cr ratios, and reduced eGFR levels are associated with more severe DKA presentations and prolonged hospital stays. The integration of these biomarkers into clinical practice may enhance early risk stratification, optimize fluid and electrolyte management, and improve overall patient outcomes.
Conclusions: These findings underscore the importance of a multidisciplinary approach in managing pediatric DKA, emphasizing the role of laboratory parameters in guiding timely and effective interventions. Further research is warranted to validate these correlations and establish standardized protocols for their application in clinical settings.
کلیدواژه‌ها
Acute kidney injury؛ BUN/Cr ratio؛ Diabetic ketoacidosis؛ Venous blood gases
مراجع
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