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ojarudi, masoud, Golchin, Ali, Karamdel, Hamid Reza, Valilo, Mohammad, Ranjbarvan, Parviz. (1404). Protective effects of Elaeagnus angustifolia L. fruit extract on CCl4-induced oxidative stress and inflammation in rats liver. , 15(5), 1519-1530. doi: 10.22038/ajp.2025.25915
masoud ojarudi; Ali Golchin; Hamid Reza Karamdel; Mohammad Valilo; Parviz Ranjbarvan. "Protective effects of Elaeagnus angustifolia L. fruit extract on CCl4-induced oxidative stress and inflammation in rats liver". , 15, 5, 1404, 1519-1530. doi: 10.22038/ajp.2025.25915
ojarudi, masoud, Golchin, Ali, Karamdel, Hamid Reza, Valilo, Mohammad, Ranjbarvan, Parviz. (1404). 'Protective effects of Elaeagnus angustifolia L. fruit extract on CCl4-induced oxidative stress and inflammation in rats liver', , 15(5), pp. 1519-1530. doi: 10.22038/ajp.2025.25915
ojarudi, masoud, Golchin, Ali, Karamdel, Hamid Reza, Valilo, Mohammad, Ranjbarvan, Parviz. Protective effects of Elaeagnus angustifolia L. fruit extract on CCl4-induced oxidative stress and inflammation in rats liver. , 1404; 15(5): 1519-1530. doi: 10.22038/ajp.2025.25915

Protective effects of Elaeagnus angustifolia L. fruit extract on CCl4-induced oxidative stress and inflammation in rats liver

Avicenna Journal of Phytomedicine
دوره 15، شماره 5، آذر و دی 2025، صفحه 1519-1530    اصل مقاله (1.21 M)
نوع مقاله: Original Research Article
شناسه دیجیتال (DOI): 10.22038/ajp.2025.25915
نویسندگان
masoud ojarudi1؛ Ali Golchin2؛ Hamid Reza Karamdel1؛ Mohammad Valilo1؛ Parviz Ranjbarvan* 2
1Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
2Department of Applied Cell Sciences, School of Medicine, Urmia University of Medical Sciences, Urmia, Islamic Republic of Iran
چکیده
Objective: Hepatic cells face oxidative stress-induced damage, but plant antioxidants may offer protection. This study aimed to assess Elaeagnus angustifolia L. fruit extract's potential in shielding rat livers from CCl4 damage.
Materials and Methods: 30 Male Wistar rats were randomly divided into five groups: normal control (received distilled water), E. angustifolia hydroalcoholic extract control, CCl4 control, E. angustifolia extract pretreatment (600 mg/kg), and silymarin pretreatment (100 mg/kg). After 14 days of oral administration of extracts, CCl4 was injected intraperitoneally. The samples were collected 48 hr later. Histological and biochemical analyses were then carried out.
Results: CCl4 injection caused significant (p<0.001) changes in liver serum enzymes, lipid profile, bilirubin, total protein, serum albumin, antioxidant enzymes, malondialdehyde, Inflammatory cytokines, and liver tissue morphology. E. angustifolia extract pre-treatment significantly (p<0.05) returned changes to the normal state.
Conclusion: This study's findings revealed that E. angustifolia extract pretreatment could reduce liver injury caused by CCl4 in rats.
کلیدواژه‌ها
Elaeagnus angustifolia L؛ Carbon tetrachloride؛ Liver damage؛ Oxidative stress؛ Antioxidant
آمار
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