سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Mohammadi-Bajgiran, Maryam, Saffar-Khorasani, Reyhaneh, Islampanah, Muhammad, Nejad Shahrokh Abadi, Reza, Shahri, ‌Bahram, Saffar Soflaei, Sara, Nemati-Khorasani, Souren, Esmaily, Habibollah, Ferns, Gordon, Moohebati, Mohsen, Ghayour-Mobarhan, Majid. (1404). Association between ECG Abnormalities and Hookah and Cigarette Smoking in the MASHAD Cohort Study Subjects. , 13(2), 1509-1521. doi: 10.22038/jctm.2025.79903.1486
Maryam Mohammadi-Bajgiran; Reyhaneh Saffar-Khorasani; Muhammad Islampanah; Reza Nejad Shahrokh Abadi; ‌Bahram Shahri; Sara Saffar Soflaei; Souren Nemati-Khorasani; Habibollah Esmaily; Gordon A. Ferns; Mohsen Moohebati; Majid Ghayour-Mobarhan. "Association between ECG Abnormalities and Hookah and Cigarette Smoking in the MASHAD Cohort Study Subjects". , 13, 2, 1404, 1509-1521. doi: 10.22038/jctm.2025.79903.1486
Mohammadi-Bajgiran, Maryam, Saffar-Khorasani, Reyhaneh, Islampanah, Muhammad, Nejad Shahrokh Abadi, Reza, Shahri, ‌Bahram, Saffar Soflaei, Sara, Nemati-Khorasani, Souren, Esmaily, Habibollah, Ferns, Gordon, Moohebati, Mohsen, Ghayour-Mobarhan, Majid. (1404). 'Association between ECG Abnormalities and Hookah and Cigarette Smoking in the MASHAD Cohort Study Subjects', , 13(2), pp. 1509-1521. doi: 10.22038/jctm.2025.79903.1486
Mohammadi-Bajgiran, Maryam, Saffar-Khorasani, Reyhaneh, Islampanah, Muhammad, Nejad Shahrokh Abadi, Reza, Shahri, ‌Bahram, Saffar Soflaei, Sara, Nemati-Khorasani, Souren, Esmaily, Habibollah, Ferns, Gordon, Moohebati, Mohsen, Ghayour-Mobarhan, Majid. Association between ECG Abnormalities and Hookah and Cigarette Smoking in the MASHAD Cohort Study Subjects. , 1404; 13(2): 1509-1521. doi: 10.22038/jctm.2025.79903.1486

Association between ECG Abnormalities and Hookah and Cigarette Smoking in the MASHAD Cohort Study Subjects

Journal of Cardio-Thoracic Medicine
مقاله 2، دوره 13، شماره 2، شهریور 2025، صفحه 1509-1521    اصل مقاله (1.57 M)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22038/jctm.2025.79903.1486
نویسندگان
Maryam Mohammadi-Bajgiran1، 2؛ Reyhaneh Saffar-Khorasani1، 2؛ Muhammad Islampanah3؛ Reza Nejad Shahrokh Abadi4؛ ‌Bahram Shahri5؛ Sara Saffar Soflaei1، 2؛ Souren Nemati-Khorasani1، 2؛ Habibollah Esmaily6، 7؛ Gordon A. Ferns8؛ Mohsen Moohebati5، 9؛ Majid Ghayour-Mobarhan* 1، 2
1Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
2International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
3Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
4Clinical Research Development Unit, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
5Department of Cardiovascular Diseases, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
6Department of Biostatistics, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran.
7Social Determinants of Health Research center, Mashhad University of Medical Sciences, Mashhad, Iran.
8Brighton and Sussex Medical School, Division of Medical Education, Brighton, UK.
9Heart and Vascular Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
چکیده
Introduction: Tobacco use, including cigarette and hookah smoking, is a major public health issue due to its association with cardiovascular disease (CVD). Cigarette and hookah smoking introduce harmful substances that lead to atherosclerosis, endothelial dysfunction, and myocardial ischemia, resulting in significant cardiovascular morbidity and mortality. In this study, we aimed to assess the association between hookah and cigarette smoking and ECG patterns using Minnesota Coding (MC) system in a large-scale population.
Methods: This study utilized data from the Mashhad Stroke and Heart Atherosclerotic Disorder (MASHAD) cohort, involving 9,704 participants aged 35-65 years. Demographic data, physical measurements, smoking habits, and medical histories were collected. Resting 12-lead ECGs were analyzed using the MC system to identify minor and major ECG abnormalities. Statistical analyses included binary logistic regression adjusted for sex, BMI, education, and employment status, as well as chi-squared tests.
Results: The final analysis included 8,821 participants. Cigarette users (92.3% male) had significantly lower BMI and higher employment rates compared to non-smokers, whereas hookah smokers (90.2% female) had higher BMIs and were predominantly retirees. Cigarette smokers exhibited a higher prevalence of minor ECG abnormalities (25.6% vs. 20.2%, p = 0.001), particularly ST-segment elevation, left axis deviation, sinus bradycardia, and high amplitude P-waves. Logistic regression confirmed significant associations for sinus bradycardia (OR: 1.600, 95% CI: 1.127-2.271, p = 0.009) and high amplitude P-waves (OR: 4.775, 95% CI: 1.771-12.880, p = 0.002). Hookah smokers had higher rates of left ventricular hypertrophy plus ST-T abnormalities (7.9% vs. 5.0%, p = 0.027) and a significantly lower prevalence of sinus tachycardia (0.3% vs. 1.6%, p = 0.042).
Conclusion: Cigarette and hookah smoking are associated with specific ECG abnormalities, suggesting significant cardiovascular effects. The persistence of certain abnormalities after adjustment underscores the long-term impact of smoking on cardiac function. Further research is needed to elucidate the mechanisms and mitigate the cardiovascular risks associated with various forms of tobacco use.
کلیدواژه‌ها
Cigarette؛ Electrocardiogram؛ Hookah؛ Smoking؛ Tobacco
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