سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Saadh, Mohamed J., Qutaiba B. Allela, Omer, Abdul Kareem, Radhwan, Sanghvi, Gaurav, Priya, G. Padma, Thakur, Rishabh, Kumari, Mukesh, Gupta, Sofia, Khaitov, Kakhramon, Naji Sameer, Hayder, Yaseen, Ahmed, Athab, Zainab H., Adil, Mohaned. (1404). Psoriasis: Immunological and genetic blueprints driving pathogenesis and potential for personalized therapies. , 28(6), 680-690. doi: 10.22038/ijbms.2025.85335.18442
Mohamed J. Saadh; Omer Qutaiba B. Allela; Radhwan Abdul Kareem; Gaurav Sanghvi; G. Padma Priya; Rishabh Thakur; Mukesh Kumari; Sofia Gupta; Kakhramon Khaitov; Hayder Naji Sameer; Ahmed Yaseen; Zainab H. Athab; Mohaned Adil. "Psoriasis: Immunological and genetic blueprints driving pathogenesis and potential for personalized therapies". , 28, 6, 1404, 680-690. doi: 10.22038/ijbms.2025.85335.18442
Saadh, Mohamed J., Qutaiba B. Allela, Omer, Abdul Kareem, Radhwan, Sanghvi, Gaurav, Priya, G. Padma, Thakur, Rishabh, Kumari, Mukesh, Gupta, Sofia, Khaitov, Kakhramon, Naji Sameer, Hayder, Yaseen, Ahmed, Athab, Zainab H., Adil, Mohaned. (1404). 'Psoriasis: Immunological and genetic blueprints driving pathogenesis and potential for personalized therapies', , 28(6), pp. 680-690. doi: 10.22038/ijbms.2025.85335.18442
Saadh, Mohamed J., Qutaiba B. Allela, Omer, Abdul Kareem, Radhwan, Sanghvi, Gaurav, Priya, G. Padma, Thakur, Rishabh, Kumari, Mukesh, Gupta, Sofia, Khaitov, Kakhramon, Naji Sameer, Hayder, Yaseen, Ahmed, Athab, Zainab H., Adil, Mohaned. Psoriasis: Immunological and genetic blueprints driving pathogenesis and potential for personalized therapies. , 1404; 28(6): 680-690. doi: 10.22038/ijbms.2025.85335.18442

Psoriasis: Immunological and genetic blueprints driving pathogenesis and potential for personalized therapies

Iranian Journal of Basic Medical Sciences
مقاله 1، دوره 28، شماره 6، شهریور 2025، صفحه 680-690    اصل مقاله (344.37 K)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2025.85335.18442
نویسندگان
Mohamed J. Saadh1؛ Omer Qutaiba B. Allela* 2؛ Radhwan Abdul Kareem3؛ Gaurav Sanghvi4؛ G. Padma Priya5؛ Rishabh Thakur6؛ Mukesh Kumari7؛ Sofia Gupta8؛ Kakhramon Khaitov9؛ Hayder Naji Sameer10؛ Ahmed Yaseen11؛ Zainab H. Athab12؛ Mohaned Adil13
1Faculty of Pharmacy, Middle East University, Amman, 11831, Jordan
2College of Pharmacy, Alnoor University, Nineveh, Iraq
3Ahl Al Bayt University, Kerbala, Iraq
4Marwadi University Research Center, Department of Microbiology, Faculty of Science, Marwadi University, Rajkot-360003, Gujarat, India
5Department of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to be University), Bangalore, Karnataka, India
6Centre for Research Impact & Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University, Rajpura, 140401, Punjab, India
7Department of Applied Sciences-Chemistry, NIMS Institute of Engineering & Technology, NIMS University Rajasthan, Jaipur, India
8Department of Chemistry, Chandigarh Engineering College, Chandigarh Group of Colleges-Jhanjeri, Mohali140307, Punjab, India
9Department of Dermatovenerology, Pediatric Dermatovenerology and AIDS, Tashkent Pediatric Medical Institute, Bogishamol Street 223, Tashkent, 100140, Uzbekistan
10College of Pharmacy, National University of Science and Technology, Dhi Qar, 64001, Iraq
11Gilgamesh Ahliya University, Baghdad, Iraq
12Department of Pharmacy, Al-Zahrawi University College, Karbala, Iraq
13Pharmacy College, Al-Farahidi University, Iraq
چکیده
Psoriasis is a long-lasting inflammatory skin condition that impacts millions globally. The occurrence of this disorder differs significantly across various areas, resulting from a complex interplay of genetic and environmental influences. In psoriasis, the pathogenesis represents a complex interaction of innate and adaptive immunity that plays a significant role in the disease manifestation process. Many genetic factors predispose to psoriasis, which is considered a polygenic disease. Several genes concerning pathways like NF-κB and PI3K/Akt that modulate the amplification of inflammatory response and keratinocyte dysregulation have been elaborated in the light of their differential expression, susceptibility loci, and polymorphisms. Such genetic insights could open a whole new avenue for precision medicine in which biomarkers and gene-targeting therapies are promising options for personalized treatment. This review emphasizes the need for complex investigations into psoriasis, from molecular mechanisms to clinical manifestations, to bridge the gap between basic research and therapeutic development by furthering the understanding of psoriasis and paving the way for innovative treatments addressing skin lesions and systemic effects.
کلیدواژه‌ها
Genetic predisposition؛ Immunopathogenesis؛ Inflammation؛ Personalized medicine؛ Psoriasis
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