Asadi, Ali, Kalalinia, BiBi Fatemeh, Marouzi, Somayeh, Salmasi, Zahra, Hashemi, Maryam. (1404). An overview of the therapeutic applications of cinnamon-loaded in nanosystems. , 12(3), 370-391. doi: 10.22038/nmj.2025.82728.2066
Ali Asadi; BiBi Fatemeh Kalalinia; Somayeh Marouzi; Zahra Salmasi; Maryam Hashemi. "An overview of the therapeutic applications of cinnamon-loaded in nanosystems". , 12, 3, 1404, 370-391. doi: 10.22038/nmj.2025.82728.2066
Asadi, Ali, Kalalinia, BiBi Fatemeh, Marouzi, Somayeh, Salmasi, Zahra, Hashemi, Maryam. (1404). 'An overview of the therapeutic applications of cinnamon-loaded in nanosystems', , 12(3), pp. 370-391. doi: 10.22038/nmj.2025.82728.2066
Asadi, Ali, Kalalinia, BiBi Fatemeh, Marouzi, Somayeh, Salmasi, Zahra, Hashemi, Maryam. An overview of the therapeutic applications of cinnamon-loaded in nanosystems. , 1404; 12(3): 370-391. doi: 10.22038/nmj.2025.82728.2066

An overview of the therapeutic applications of cinnamon-loaded in nanosystems

Nanomedicine Journal
مقاله 3، دوره 12، شماره 3، پاییز 2025، صفحه 370-391    اصل مقاله (730.58 K)
نوع مقاله: Review Paper
شناسه دیجیتال (DOI): 10.22038/nmj.2025.82728.2066
نویسندگان
Ali Asadi1، 2؛ BiBi Fatemeh Kalalinia3، 4؛ Somayeh Marouzi4؛ Zahra Salmasi* 5، 6؛ Maryam Hashemi* 4، 5
1School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
2Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran
3Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
4Departments of Pharmaceutical Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
5Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
6Departments of Pharmaceutical Nanotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Cinnamon, a spice derived from the Cinnamomum genus, has a rich history of traditional medicinal applications. Its therapeutic potential arises from a diverse array of bioactive compounds exhibiting antioxidant, anti-inflammatory, and antimicrobial properties. However, the inherent properties  of cinnamon, such as poor solubility and instability, have limited its clinical applications. Nanotechnology has emerged as a promising approach to overcome these challenges. By encapsulating cinnamon extract/essential oil within nanoscale carriers, researchers have achieved enhanced bioavailability, solubility, controlled release of its bioactive constituents and therapeutic outcomes. This review comprehensively explores various nano-formulations, to improve the cinnamon’s bioactive compounds delivery for biomedical applications. Preclinical studies have demonstrated the efficacy of cinnamon-based nanomaterials in addressing a range of human diseases, including cancer, diabetes, infections, and neurodegenerative disorders. Despite these promising advancements, further research is imperative to elucidate the precise mechanisms of action, optimize formulations, and conduct accurate clinical trials to translate these findings into effective human therapies. 
کلیدواژه‌ها
Cinnamon؛ Nanoparticles؛ Phytochemicals؛ Drug Delivery Systems؛ Biological Availability
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