Hossainpour, Hadi, Alvandi, Hosna, Abiri, Ramin, Aghaz, Faranak, Alvandi, Amirhooshang, Arkan, Elham. (1404). Preparation and characterization of gelatin/ sodium alginate with thymus Kotschyanus hydrogel for wound healing, In Vitro study. , 12(3), 443-453. doi: 10.22038/nmj.2025.83422.2088
Hadi Hossainpour; Hosna Alvandi; Ramin Abiri; Faranak Aghaz; Amirhooshang Alvandi; Elham Arkan. "Preparation and characterization of gelatin/ sodium alginate with thymus Kotschyanus hydrogel for wound healing, In Vitro study". , 12, 3, 1404, 443-453. doi: 10.22038/nmj.2025.83422.2088
Hossainpour, Hadi, Alvandi, Hosna, Abiri, Ramin, Aghaz, Faranak, Alvandi, Amirhooshang, Arkan, Elham. (1404). 'Preparation and characterization of gelatin/ sodium alginate with thymus Kotschyanus hydrogel for wound healing, In Vitro study', , 12(3), pp. 443-453. doi: 10.22038/nmj.2025.83422.2088
Hossainpour, Hadi, Alvandi, Hosna, Abiri, Ramin, Aghaz, Faranak, Alvandi, Amirhooshang, Arkan, Elham. Preparation and characterization of gelatin/ sodium alginate with thymus Kotschyanus hydrogel for wound healing, In Vitro study. , 1404; 12(3): 443-453. doi: 10.22038/nmj.2025.83422.2088

Preparation and characterization of gelatin/ sodium alginate with thymus Kotschyanus hydrogel for wound healing, In Vitro study

Nanomedicine Journal
دوره 12، شماره 3، پاییز 2025، صفحه 443-453    اصل مقاله (1.02 M)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22038/nmj.2025.83422.2088
نویسندگان
Hadi Hossainpour1؛ Hosna Alvandi2، 3؛ Ramin Abiri1، 4؛ Faranak Aghaz2؛ Amirhooshang Alvandi* 1، 5؛ Elham Arkan2
1Department of Microbiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
2Nano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
3Nanobiotechnology Department, Faculty of Innovative Science and Technology, Razi University Kermanshah, Iran
4Fertility and Infertility Research Center, Research Institute for Health Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran
5Medical Technology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
چکیده
Objective(s): Gelatin / Sodium Alginate Thymus kotschyanus (GE/SA T. kotschyanus) hydrogel was prepared for use as a wound healing.
Materials and Methods: The hydrogel was prepared by casting and cross-linking method and the physicochemical and the antimicrobial properties of the hydrogels were determined.
Results: The GE/SA hydrogel showed high mechanical properties, while the addition of the extract to the hydrogel led to the relaxation of the polymer network and thus increased the elasticity of the dressing, and it had a good biodegradation. The compatibility of hydrogels with fibroblast cells was confirmed by MTT assay. Also, GE/SA T. kotschyanus hydrogels were found to be excellent Hemocompatibile. Moreover, these hydrogels exhibited the antibacterial activity against Pseudomonas aeruginosa, and Escherichia coli. In addition, these hydrogels showed the best antifungal effect against Candida albicans.
Conclusion:  The GE/SA T. kotschyanus hydrogels had the potential for use in wound dressing.
کلیدواژه‌ها
Hydrogel؛ Gelatin؛ Sodium Alginate؛ Thymus kotschyanus؛ Wound healing
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