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Yang, Ya-jie, Liu, Bing-qing, Jiang, Yang, Zhou, Man-yu, Tuerxun, Re-yi-la, Liu, Hong-shuang, Liao, Yan. (1404). Effects and mechanism of puerarin on lactation of postpartum hypogalactia mice. , 28(6), 739-745. doi: 10.22038/ijbms.2025.81350.17611
Ya-jie Yang; Bing-qing Liu; Yang Jiang; Man-yu Zhou; Re-yi-la Tuerxun; Hong-shuang Liu; Yan Liao. "Effects and mechanism of puerarin on lactation of postpartum hypogalactia mice". , 28, 6, 1404, 739-745. doi: 10.22038/ijbms.2025.81350.17611
Yang, Ya-jie, Liu, Bing-qing, Jiang, Yang, Zhou, Man-yu, Tuerxun, Re-yi-la, Liu, Hong-shuang, Liao, Yan. (1404). 'Effects and mechanism of puerarin on lactation of postpartum hypogalactia mice', , 28(6), pp. 739-745. doi: 10.22038/ijbms.2025.81350.17611
Yang, Ya-jie, Liu, Bing-qing, Jiang, Yang, Zhou, Man-yu, Tuerxun, Re-yi-la, Liu, Hong-shuang, Liao, Yan. Effects and mechanism of puerarin on lactation of postpartum hypogalactia mice. , 1404; 28(6): 739-745. doi: 10.22038/ijbms.2025.81350.17611

Effects and mechanism of puerarin on lactation of postpartum hypogalactia mice

Iranian Journal of Basic Medical Sciences
مقاله 6، دوره 28، شماره 6، شهریور 2025، صفحه 739-745    اصل مقاله (436.11 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2025.81350.17611
نویسندگان
Ya-jie Yang1؛ Bing-qing Liu1؛ Yang Jiang1؛ Man-yu Zhou1؛ Re-yi-la Tuerxun2؛ Hong-shuang Liu1؛ Yan Liao* 1
1School of Chinese Medical, Beijing University of Chinese Medicine, Beijing, 102446, China
2Traditional Chinese Medicine Hospital of Xinjiang Uyghur Autonomous Region, Xinjiang, 830092, China
چکیده
Objective(s): Insufficient breast milk supply is a common reason cited for discontinuing breastfeeding prematurely. Natural galactagogues offer promise as a solution for mothers with low milk production. This study aimed to explore puerarin’s potential effects and underlying mechanism on lactation of postpartum hypogalactia mice.
Materials and Methods: Postpartum mice were randomly assigned to five groups: control group, agalactosis model group, domperidone group (3.5 mg/kg), low dose puerarin group (18 mg/kg), and high dose puerarin group (72 mg/kg). The effects of puerarin on postpartum hypogalactia mice were evaluated by lactation indicators and pathological morphology. Related hormones and prolactin receptor (PRLR)/Janus kinase 2 (JAK2)/signal transduction and activator (STAT) 5 signaling pathway were also measured.
Results: Puerarin significantly improved lactation yield and stimulated mammary gland development in postpartum hypogalactia mice. Additionally, puerarin increased the expression levels of β-casein, fatty acid synthase (FAS), and glucose transporter 1 (GLUT1). Mechanically, puerarin stimulated secretion of prolactin (PRL), estradiol (E2), and progesterone (P4) in agalactosis mice. Puerarin also substantially increased PRLR, JAK2, and STAT5a expression levels in postpartum hypogalactia mice. 
Conclusion: This study suggested that puerarin may promote lactation by stimulating PRL secretion and activating the PRLR/JAK2/STAT5 signaling pathway.
کلیدواژه‌ها
Breast Feeding؛ Domperidone؛ Galactogogues؛ Phytoestrogens؛ Prolactin
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