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Shirazpour, Sara, Khaksari, Mohammad, Gaeini, Abbas Ali, Bashiri, Hamideh, Khoramipour, Kayvan, Rafie, Forouzan. (1404). Can resisted swimming exercise substitute for the protective effects of estrogen on cardiometabolic risk factors in obese postmenopausal rat model?. , 28(6), 718-727. doi: 10.22038/ijbms.2025.82005.17745
Sara Shirazpour; Mohammad Khaksari; Abbas Ali Gaeini; Hamideh Bashiri; Kayvan Khoramipour; Forouzan Rafie. "Can resisted swimming exercise substitute for the protective effects of estrogen on cardiometabolic risk factors in obese postmenopausal rat model?". , 28, 6, 1404, 718-727. doi: 10.22038/ijbms.2025.82005.17745
Shirazpour, Sara, Khaksari, Mohammad, Gaeini, Abbas Ali, Bashiri, Hamideh, Khoramipour, Kayvan, Rafie, Forouzan. (1404). 'Can resisted swimming exercise substitute for the protective effects of estrogen on cardiometabolic risk factors in obese postmenopausal rat model?', , 28(6), pp. 718-727. doi: 10.22038/ijbms.2025.82005.17745
Shirazpour, Sara, Khaksari, Mohammad, Gaeini, Abbas Ali, Bashiri, Hamideh, Khoramipour, Kayvan, Rafie, Forouzan. Can resisted swimming exercise substitute for the protective effects of estrogen on cardiometabolic risk factors in obese postmenopausal rat model?. , 1404; 28(6): 718-727. doi: 10.22038/ijbms.2025.82005.17745

Can resisted swimming exercise substitute for the protective effects of estrogen on cardiometabolic risk factors in obese postmenopausal rat model?

Iranian Journal of Basic Medical Sciences
مقاله 4، دوره 28، شماره 6، شهریور 2025، صفحه 718-727    اصل مقاله (592.93 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2025.82005.17745
نویسندگان
Sara Shirazpour1؛ Mohammad Khaksari* 2؛ Abbas Ali Gaeini3؛ Hamideh Bashiri4؛ Kayvan Khoramipour1، 5؛ Forouzan Rafie4، 6
1Department of Physiology, Faculty of Medicine, Kerman University of Medical Sciences,Kerman, Iran
2Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
3Department of Exercise Physiology, University of Tehran, Tehran, Iran
4Institute of Neuropharmacology, Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran
5i+HeALTH Strategic Research Group, Department of Health Sciences, Miguel de Cervantes European University (UEMC), 47012 Valladolid, Spain
6Emory University School of Medicine Division of Geriatrics and Gerontology, Atlanta, Georgia, USA
چکیده
Objective(s): Following our previous studies on the anti-obesity and cardioprotective effects of 17-beta estradiol (E2), this study was designed to determine the effects of Resisted swimming (RSW) training and E2 (alone and in combination) on cardiometabolic risk factors in an obese postmenopausal rat model.
Materials and Methods: Female ovariectomized rats (OVX) were given a standard diet (SD) or a 60% high-fat diet (HFD) for 16 weeks and were divided into two groups:  SD and HFD. The rats were divided into ten groups to assess the effects of 8 weeks of E2 (1 mg/kg, IP) administration and RSW (5 days a week) on cardiometabolic risk factors. Parameters including body weight, BMI, visceral fat, blood glucose (BG), and cardiac oxidative stress were assessed 72 hr after the last swimming session.
Results: HFD increased body weight, BMI, visceral fat, and BG levels in OVX rats. Additionally, it negatively affected the lipid profile and cardiac oxidative stress, but both E2 and RSW reduced these parameters in HFD-fed OVX rats. Although RSW and E2 equally prevented these changes, swimming was more effective than estrogen in increasing HDL levels in the SD group. The combination of E2 and RSW had a more significant effect on modulating glucose, TAC, TG, and HDL indices than the individual treatments.  
Conclusion: Overall, RSW ameliorates cardiometabolic risk factors in postmenopausal conditions caused by obesity, probably by modulating cardiac oxidative stress. It is also an effective non-pharmacological treatment for E2 substitution. 
کلیدواژه‌ها
17 beta-estradiol؛ Bilateral ovariectomies؛ High-fat diet؛ Oxidative stress؛ Swimming
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