سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Marefat, Maryam, Kiani, Mohammad Ali, Mahdavirashed, Masoud, Afzalagaie, Monavar, Mohammadi, Saeed, Kianifar, Hamidreza, Jafari, Seyyed Ali, Khalesi, Maryam. (1403). Evaluation of the Effect of Rosuvastatin on Portal Hypertension and Variceal Bleeding in Children with Compensated Cirrhosis. , 13(1), 19254-19264. doi: 10.22038/jpp.2025.85036.5516
Maryam Marefat; Mohammad Ali Kiani; Masoud Mahdavirashed; Monavar Afzalagaie; Saeed Mohammadi; Hamidreza Kianifar; Seyyed Ali Jafari; Maryam Khalesi. "Evaluation of the Effect of Rosuvastatin on Portal Hypertension and Variceal Bleeding in Children with Compensated Cirrhosis". , 13, 1, 1403, 19254-19264. doi: 10.22038/jpp.2025.85036.5516
Marefat, Maryam, Kiani, Mohammad Ali, Mahdavirashed, Masoud, Afzalagaie, Monavar, Mohammadi, Saeed, Kianifar, Hamidreza, Jafari, Seyyed Ali, Khalesi, Maryam. (1403). 'Evaluation of the Effect of Rosuvastatin on Portal Hypertension and Variceal Bleeding in Children with Compensated Cirrhosis', , 13(1), pp. 19254-19264. doi: 10.22038/jpp.2025.85036.5516
Marefat, Maryam, Kiani, Mohammad Ali, Mahdavirashed, Masoud, Afzalagaie, Monavar, Mohammadi, Saeed, Kianifar, Hamidreza, Jafari, Seyyed Ali, Khalesi, Maryam. Evaluation of the Effect of Rosuvastatin on Portal Hypertension and Variceal Bleeding in Children with Compensated Cirrhosis. , 1403; 13(1): 19254-19264. doi: 10.22038/jpp.2025.85036.5516

Evaluation of the Effect of Rosuvastatin on Portal Hypertension and Variceal Bleeding in Children with Compensated Cirrhosis

Journal of Pediatric Perspectives
مقاله 9، دوره 13، شماره 1، فروردین 2025، صفحه 19254-19264    اصل مقاله (685.6 K)
نوع مقاله: original article
شناسه دیجیتال (DOI): 10.22038/jpp.2025.85036.5516
نویسندگان
Maryam Marefat* 1؛ Mohammad Ali Kiani2؛ Masoud Mahdavirashed3؛ Monavar Afzalagaie4؛ Saeed Mohammadi1؛ Hamidreza Kianifar2؛ Seyyed Ali Jafari2؛ Maryam Khalesi5
1Fellowship, Department of Pediatrics, Facility of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
2Professor, Department of Pediatrics, Facility of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
3Associate Professor, Department of Radiology, Facility of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
4Assistant Professor , Department of Biological Statistics, Facility of Hygiene, Mashhad University of Medical Science, Mashhad, Iran.
5Associate Professor , Department of Pediatrics, Facility of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
چکیده
Background: Portal hypertension, a complication of chronic liver disease in children, can lead to severe gastrointestinal bleeding and an increased need for hospitalization and endoscopic treatment, potentially resulting in death. Statins, known for their anti-inflammatory, antioxidant, and anti-fibrotic effects, are used in the treatment of many chronic diseases. This study aimed to investigate the effects of rosuvastatin on improving portal pressure and esophageal varices while reducing bleeding associated with these conditions in children with cirrhosis.
Methods: This randomized clinical trial was conducted in children with compensated liver cirrhosis at Akbar Children's Hospital in Mashhad, Iran, between March 2023 and November 2024. Initially, endoscopy and Doppler ultrasound were performed on 32 patients aged 7–17 years. The control group received standard treatments for portal hypertension, while the intervention group received rosuvastatin tablets in addition to standard treatments. After a 6-month period, Doppler ultrasound and control endoscopy were repeated. All clinical, laboratory, sonographic, and endoscopic data were analyzed by a statistician, and the results were reported.
Results: The study included 32 children with cirrhosis (16 in the control group and 16 in the intervention group). The number of cases showing a decrease in ultrasonographic parameters of portal hypertension (SA-RI and RRA-RI) was higher in the rosuvastatin group (p=0.14 and 0.37). The grades of esophageal varices decreased by 26.7% and 20% in the control and rosuvastatin groups, respectively (p=0.66). Esophageal variceal bleeding occurred in 13.3% of cases in the control group and in 25% of cases in the rosuvastatin group,with no statistically significant difference between the two groups (p=0.41).
Conclusion: Over the 6-month follow-up period, rosuvastatin did not demonstrate a beneficial effect in reducing portal hypertension and variceal bleeding in children with compensated liver cirrhosis.
کلیدواژه‌ها
Pediatric Cirrhosis؛ Portal Hypertension؛ Statin
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