سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Derakhshan, Alireza, mirsadraee, majid, Asnaashari, Amir-Mohammad-Hashem, Salari, Roshanak, Khadem Rezaiyan, Majid, saeidinejat, shahin, Jalali, Shima, Jalali, Shabnam, Ghaffari, Shadi. (1404). Effect of a Persian medicine formula, Glasthma, on lung function and intestinal permeability in Asthma: A triple-blind randomized controlled trial. , 15(5), 1424-1437. doi: 10.22038/ajp.2025.25579
Alireza Derakhshan; majid mirsadraee; Amir-Mohammad-Hashem Asnaashari; Roshanak Salari; Majid Khadem Rezaiyan; shahin saeidinejat; Shima Jalali; Shabnam Jalali; Shadi Ghaffari. "Effect of a Persian medicine formula, Glasthma, on lung function and intestinal permeability in Asthma: A triple-blind randomized controlled trial". , 15, 5, 1404, 1424-1437. doi: 10.22038/ajp.2025.25579
Derakhshan, Alireza, mirsadraee, majid, Asnaashari, Amir-Mohammad-Hashem, Salari, Roshanak, Khadem Rezaiyan, Majid, saeidinejat, shahin, Jalali, Shima, Jalali, Shabnam, Ghaffari, Shadi. (1404). 'Effect of a Persian medicine formula, Glasthma, on lung function and intestinal permeability in Asthma: A triple-blind randomized controlled trial', , 15(5), pp. 1424-1437. doi: 10.22038/ajp.2025.25579
Derakhshan, Alireza, mirsadraee, majid, Asnaashari, Amir-Mohammad-Hashem, Salari, Roshanak, Khadem Rezaiyan, Majid, saeidinejat, shahin, Jalali, Shima, Jalali, Shabnam, Ghaffari, Shadi. Effect of a Persian medicine formula, Glasthma, on lung function and intestinal permeability in Asthma: A triple-blind randomized controlled trial. , 1404; 15(5): 1424-1437. doi: 10.22038/ajp.2025.25579

Effect of a Persian medicine formula, Glasthma, on lung function and intestinal permeability in Asthma: A triple-blind randomized controlled trial

Avicenna Journal of Phytomedicine
دوره 15، شماره 5، آذر و دی 2025، صفحه 1424-1437    اصل مقاله (711.2 K)
نوع مقاله: Original Research Article
شناسه دیجیتال (DOI): 10.22038/ajp.2025.25579
نویسندگان
Alireza Derakhshan1؛ majid mirsadraee2؛ Amir-Mohammad-Hashem Asnaashari3؛ Roshanak Salari4؛ Majid Khadem Rezaiyan5؛ shahin saeidinejat* 6؛ Shima Jalali7؛ Shabnam Jalali8؛ Shadi Ghaffari9
1School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
23. Majid Mirsadraee, Department of Internal Medicine, Faculty of Medicine, Islamic Azad University-Mashhad Branch, Mashhad, Iran. ORCID ID:0000-0003-3420-9438. .
3COPD Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. ORCID ID: 0000-0003- 2960-7132.
4Department of Pharmaceutical Sciences in Persian Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
5Department of Community Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, iran
6Department of Traditional Persian Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
7Medical student , Mashhad University of Medical Sciences, Mashhad, Iran. ORCID ID: Medical student , Mashhad University of Medical Sciences, Mashhad, Iran. ORCID ID: 0000-0002-0696-2564. Shimajalali1374@gmail.com .
8Medical student , Mashhad University of Medical Sciences, Mashhad, Iran. ORCID ID: 0000-0002-9093-0660.
9Department of biology, Islamic Azad University- Damghan Branch,. 0000-0002-9176-8650
چکیده
Objective: This study aimed to evaluate Glasthma, a Persian medicine herbal formulation for its efficacy and safety in managing asthma symptoms and modulating intestinal permeability.
Materials and Methods: Forty randomly assigned asthma patients received Glasthma syrup (n=20) or a placebo (n=20) twice daily for 4 weeks. Respiratory symptoms, pulmonary function tests, and 5-hour urine lactulose to mannitol ratio were assessed at baseline and after 4 weeks.
Results: Glasthma group exhibited significant improvements in clinical and paraclinical scores, including asthma control test (p<0.001), asthma control questionnaire 7 (p<0.007), Forced Expiratory Volume in the First Second (p<0.001), and Maximal Mid-Expiratory Flow 25-75 (p<0.002) compared to the placebo group. Lactulose and mannitol levels significantly decreased in the Glasthma group (p<0.028 and p<0.0000, respectively), with no significant changes in the ratio. No serious adverse effects were observed.
Conclusion: These findings suggest that Glasthma formulation may effectively improve asthma symptoms and regulate the gut-lung axis.
کلیدواژه‌ها
Asthma؛ Intestinal permeability؛ Traditional Persian medicine Phytotherapy
آمار
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