سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Omidi, Mahmoud, Morteza-Semnani, Katayoun, Saeedi, Majid, Frahmand, Mina, Kamali, Marzie, Mohammadian, Esmaeil, Hashemi, Seyyed Mohammad Hassan. (1404). Lavender essential oil nanoemulsion gel as skin lightener: green formulation, full characterization, anti-melanogenesis effect, and in-vitro/in-vivo safety profile assessment. , 12(3), 404-420. doi: 10.22038/nmj.2025.80954.2004
Mahmoud Omidi; Katayoun Morteza-Semnani; Majid Saeedi; Mina Frahmand; Marzie Kamali; Esmaeil Mohammadian; Seyyed Mohammad Hassan Hashemi. "Lavender essential oil nanoemulsion gel as skin lightener: green formulation, full characterization, anti-melanogenesis effect, and in-vitro/in-vivo safety profile assessment". , 12, 3, 1404, 404-420. doi: 10.22038/nmj.2025.80954.2004
Omidi, Mahmoud, Morteza-Semnani, Katayoun, Saeedi, Majid, Frahmand, Mina, Kamali, Marzie, Mohammadian, Esmaeil, Hashemi, Seyyed Mohammad Hassan. (1404). 'Lavender essential oil nanoemulsion gel as skin lightener: green formulation, full characterization, anti-melanogenesis effect, and in-vitro/in-vivo safety profile assessment', , 12(3), pp. 404-420. doi: 10.22038/nmj.2025.80954.2004
Omidi, Mahmoud, Morteza-Semnani, Katayoun, Saeedi, Majid, Frahmand, Mina, Kamali, Marzie, Mohammadian, Esmaeil, Hashemi, Seyyed Mohammad Hassan. Lavender essential oil nanoemulsion gel as skin lightener: green formulation, full characterization, anti-melanogenesis effect, and in-vitro/in-vivo safety profile assessment. , 1404; 12(3): 404-420. doi: 10.22038/nmj.2025.80954.2004

Lavender essential oil nanoemulsion gel as skin lightener: green formulation, full characterization, anti-melanogenesis effect, and in-vitro/in-vivo safety profile assessment

Nanomedicine Journal
مقاله 5، دوره 12، شماره 3، مهر 2025، صفحه 404-420    اصل مقاله (955.14 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22038/nmj.2025.80954.2004
نویسندگان
Mahmoud Omidi1، 2؛ Katayoun Morteza-Semnani3؛ Majid Saeedi4؛ Mina Frahmand5؛ Marzie Kamali6؛ Esmaeil Mohammadian* 1، 7؛ Seyyed Mohammad Hassan Hashemi* 1، 8
1Food Health Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
2Department of Pharmacology and Toxicology, Faculty of Pharmacy, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
3Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
4Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
5Student Research Committee, Faculty of Pharmacy, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
6Molecular Medicine Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
7Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
8Department of Pharmaceutics, Faculty of Pharmacy, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
چکیده
Objective(s): In this study, to improve anti-melanogenesis properties, the green method based on an ultrasonic approach was utilized to prepare lavender essential oil (LEO) nanoemulgel.
Material and Methods: Nano-emulsion green preparation, physico-chemical characterization, inspection morphology, animal safety study, cellar toxicity and anti-pigmentation test were performed.
Results: The obtained results showed that with a decline in HLB value (Hydrophilic–lipophilic balance), the mean particle size declined from 157.600±3.798 to 85.566± 2.227 nm (P< 0.05). The evaluations performed with the accelerated stability test (freeze-thaw cycle) showed stability for nanoemulgel. Other factors, such as pH, spreadability, and, viscosity were also measured. In vitro cytotoxicity studies for the revealed LEO-nanoemulsion, on the HFF normal cell line showed less toxicity (73%) than pure LEO. Moreover, LEO-nanoemulsion had a higher cytotoxic impact on B16F10 melanoma cancer cells than pure LEO. The inhibitory activity of this LEO-nanoemulsion was evaluated in melanin content, which indicated that melanin synthesis is more inhibited than LEO. Furthermore, the evaluation of the inhibitory activity presented that the inhibition of L-dopa auto oxidation (87.33± 2.45%) is better than that of LEO (74.22± 3.26%) at a concentration of 5000 µg/ml. It should be noted that no skin irritation was observed with the histo-pathological examination on Wistar rat and the dermal irritation study for the LEO-nanoemulgel.
Conclusion: The results of the present study can be very useful for the introduction and local administration of LEO nanoemulgel for the management of hyperpigmentation conditions.
کلیدواژه‌ها
Lavender؛ Essential oil؛ Nanotechnology؛ Green method؛ Anti-melanogenesis
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