سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Marouzi, Somayeh, Sammak, Shirin, Sadri, Kayvan, Darroudi, Majid. (1404). Bioimaging comparison between synthesized carbon quantum dots and nanodiamonds. , 12(3), 529-545. doi: 10.22038/nmj.2025.81851.2037
Somayeh Marouzi; Shirin Sammak; Kayvan Sadri; Majid Darroudi. "Bioimaging comparison between synthesized carbon quantum dots and nanodiamonds". , 12, 3, 1404, 529-545. doi: 10.22038/nmj.2025.81851.2037
Marouzi, Somayeh, Sammak, Shirin, Sadri, Kayvan, Darroudi, Majid. (1404). 'Bioimaging comparison between synthesized carbon quantum dots and nanodiamonds', , 12(3), pp. 529-545. doi: 10.22038/nmj.2025.81851.2037
Marouzi, Somayeh, Sammak, Shirin, Sadri, Kayvan, Darroudi, Majid. Bioimaging comparison between synthesized carbon quantum dots and nanodiamonds. , 1404; 12(3): 529-545. doi: 10.22038/nmj.2025.81851.2037

Bioimaging comparison between synthesized carbon quantum dots and nanodiamonds

Nanomedicine Journal
دوره 12، شماره 3، مهر 2025، صفحه 529-545    اصل مقاله (1.17 M)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22038/nmj.2025.81851.2037
نویسندگان
Somayeh Marouzi1؛ Shirin Sammak2؛ Kayvan Sadri3؛ Majid Darroudi* 3
1Department of Pharmaceutical Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
2Department of Medical Biotechnology and Nanotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Objective(s): Scientists have been focused on finding access to the potential of different materials, incredibly natural substances. This work compared two categories of nanoscale materials based on carbon sources, including carbon quantum dots (C-QDs) and detonation nanodiamonds (DNDs).
Materials and Methods: The hydrothermally synthesized C-QDs from Salvia Hispanic L. and DNDs were compared through physicochemical tests such as ultra-violet spectrophotometry (UV-Vis), Fourier transform infrared (FT-IR), X-ray diffraction (XRD), and field emission scanning microscopy (FESEM). Then, we investigated their cytotoxicity and biocompatibility on HEK293 and HepG2 cell lines, respectively. To focus on nanoparticle biodistribution and shelf life throughout the in vivo studies of rats, C-QDs and DNDs were labeled by Technetium (99mTc) radioisotope for tracking purposes.
Results: The characterization and cytotoxicity outcomes of C-QDs and DNDs confirmed both cases' relative intrinsic similarity and non-toxicity, which also gained permission to enter the in vivo studies of rats.
Conclusion: According to biodistribution assessments, despite the slight differences between their biological properties, C-QDs, and DNDs exhibited different bioaccumulation tendencies toward organ selection.
کلیدواژه‌ها
Carbon quantum dots؛ Technetium؛ Nanodiamonds؛ Hydrothermal synthesis؛ Bioimaging
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