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Bagheripoor, Hesamodin, Mondanizadeh, Mahdieh, Sadegh, Mehdi. (1404). Carvacrol alleviates the proconvulsive effects of lipopolysaccharide (LPS) and reduces the gene expression of proinflammatory cytokines interleukin-1 and tumor necrosis factor-α. , 15(5), 1385-1392. doi: 10.22038/ajp.2025.25518
Hesamodin Bagheripoor; Mahdieh Mondanizadeh; Mehdi Sadegh. "Carvacrol alleviates the proconvulsive effects of lipopolysaccharide (LPS) and reduces the gene expression of proinflammatory cytokines interleukin-1 and tumor necrosis factor-α". , 15, 5, 1404, 1385-1392. doi: 10.22038/ajp.2025.25518
Bagheripoor, Hesamodin, Mondanizadeh, Mahdieh, Sadegh, Mehdi. (1404). 'Carvacrol alleviates the proconvulsive effects of lipopolysaccharide (LPS) and reduces the gene expression of proinflammatory cytokines interleukin-1 and tumor necrosis factor-α', , 15(5), pp. 1385-1392. doi: 10.22038/ajp.2025.25518
Bagheripoor, Hesamodin, Mondanizadeh, Mahdieh, Sadegh, Mehdi. Carvacrol alleviates the proconvulsive effects of lipopolysaccharide (LPS) and reduces the gene expression of proinflammatory cytokines interleukin-1 and tumor necrosis factor-α. , 1404; 15(5): 1385-1392. doi: 10.22038/ajp.2025.25518

Carvacrol alleviates the proconvulsive effects of lipopolysaccharide (LPS) and reduces the gene expression of proinflammatory cytokines interleukin-1 and tumor necrosis factor-α

Avicenna Journal of Phytomedicine
دوره 15، شماره 5، آذر و دی 2025، صفحه 1385-1392    اصل مقاله (797.39 K)
نوع مقاله: Short communication
شناسه دیجیتال (DOI): 10.22038/ajp.2025.25518
نویسندگان
Hesamodin Bagheripoor1؛ Mahdieh Mondanizadeh2؛ Mehdi Sadegh* 3
1Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran.
2Department of Biotechnology and Molecular Medicine, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran.
3Department of Physiology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran
چکیده
Objective: Carvacrol has anti-inflammatory effects. According to the links between inflammatory processes and seizures, this study was designed to investigate the potential effect of carvacrol in reducing seizure severity and involvement of hippocampal pro- and anti-inflammatory cytokines.
Materials and Methods: This research was conducted on 42 adult male Wistar rats. Animals were randomly divided into seven groups (n=6). Seizures were induced by PTZ (Pentylenetetrazol) injection (80 mg/kg). LPS (lippolysaccharide) was injected (400 μg/kg) 4 hr before PTZ. Carvacrol (100 mg/kg) was injected immediately after LPS. All injections were intraperitoneal (i.p.). Experimental groups were as follows: 1. Control (Cnt) 2. Carvacrol (Cav); 3. LPS; 4. PTZ, 5. PTZ+LPS; 6. PTZ+Cav; 7. PTZ+LPS+Cav. Seizures were observed for 30 min after the PTZ injection and the occurrence of behavioral stages of seizures was recorded. Following the behavioral study, hippocampal samples were collected for gene expression evaluation using the Real Time-PCR technique to assess IL (interleukin)-1, IL-6, IL-4 and TNF (tumor necrosis factor)-α gene expression.
Results: The current study showed that receiving LPS exacerbated seizures in the studied groups. Carvacrol reduced the severity of seizures in the LPS-receiving groups. In the gene expression study, receiving LPS increased the expression of cytokines TNF-α and IL-1 in the hippocampal tissue. Carvacrol significantly decreased gene expression of TNF-α and IL-1.No significant changes were detected for IL-6, IL-4 gene expression.
Conclusion: There could be a relationship between carvacrol ability to modulate the proconvulsive effects of LPS and its ability to decrease the gene expression of inflammatory cytokines.
کلیدواژه‌ها
Inflammation Interleukin 6 (IL؛ 6) Interleukin 4 (IL؛ 4) Seizure
آمار
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