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Jafari-zarea, Mohammadali, Yousefian, Mahzad, Amani, Frouz, Panahpour, Hamdollah, Fada, Mahsa. (1403). Comparing the effect of intravenous tranexamic acid by continuous infusion method with a separate intravenous method on bleeding after the simultaneous bilateral knee Arthroplasty. , 12(4), 197-202. doi: 10.22038/psj.2025.83919.1447
Mohammadali Jafari-zarea; Mahzad Yousefian; Frouz Amani; Hamdollah Panahpour; Mahsa Fada. "Comparing the effect of intravenous tranexamic acid by continuous infusion method with a separate intravenous method on bleeding after the simultaneous bilateral knee Arthroplasty". , 12, 4, 1403, 197-202. doi: 10.22038/psj.2025.83919.1447
Jafari-zarea, Mohammadali, Yousefian, Mahzad, Amani, Frouz, Panahpour, Hamdollah, Fada, Mahsa. (1403). 'Comparing the effect of intravenous tranexamic acid by continuous infusion method with a separate intravenous method on bleeding after the simultaneous bilateral knee Arthroplasty', , 12(4), pp. 197-202. doi: 10.22038/psj.2025.83919.1447
Jafari-zarea, Mohammadali, Yousefian, Mahzad, Amani, Frouz, Panahpour, Hamdollah, Fada, Mahsa. Comparing the effect of intravenous tranexamic acid by continuous infusion method with a separate intravenous method on bleeding after the simultaneous bilateral knee Arthroplasty. , 1403; 12(4): 197-202. doi: 10.22038/psj.2025.83919.1447

Comparing the effect of intravenous tranexamic acid by continuous infusion method with a separate intravenous method on bleeding after the simultaneous bilateral knee Arthroplasty

Journal of Patient Safety & Quality Improvement
مقاله 7، دوره 12، شماره 4، دی 2024، صفحه 197-202    اصل مقاله (276.67 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/psj.2025.83919.1447
نویسندگان
Mohammadali Jafari-zarea1؛ Mahzad Yousefian* 2؛ Frouz Amani3؛ Hamdollah Panahpour4؛ Mahsa Fada5
1Department of Orthopedic, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
2Department of Anethesiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
3Department of Community Medicine, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
4Department of Physiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
5School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
چکیده
Introduction:
Significant postoperative bleeding is linked to total knee arthroplasty (TKA), and tranexamic acid (TXA), a strong medication with strong anti-fibrinolytic properties, can lessen surgical bleeding. This study compared the effects of continuous intravenous tranexamic acid infusion with a separate intravenous approach concerning postoperative bleeding in synchronic bilateral knee arthroplasty.
 
Materials and Methods:
Hemoglobin changes (24 and 48 hours after surgery), the gases used during the procedure, and the amount of bleeding were assessed in 120 patients who had simultaneous bilateral knee replacement surgery and received intravenous tranexamic acid by continuous infusion (n = 40), single intravenous injection (n = 40), or without injection (n = 40).
 
Results:
In 120 patients who underwent simultaneous bilateral knee replacement surgery and received intravenous tranexamic acid by continuous infusion (n = 40), single intravenous injection (n = 40), or no injection (n=40), hemoglobin changes (24, 48 hours postoperatively), the gases used during the procedure, and the extent of bleeding were evaluated.
 
Conclusion:
The current study's findings demonstrated that the rate of postoperative hemorrhage and the quantity of gases used in continuous infusion and stat intravenous were reduced compared to the control group. Furthermore, the continuous infusion strategy decreased postoperative hemorrhage and gas consumption compared to the stat intravenous approach.
کلیدواژه‌ها
Total knee arthroplasty؛ Tranexamic acid؛ Postoperative bleeding
مراجع
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آمار
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