سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Nasution, Irnanda, Haryuna, Tengku Siti, Munir, Delfitri, Nasution, Syafrizal, Eyanoer, Putri, Nursiah, Siti, Sitompul, Ramlan. (1403). Correlation Between Indoxyl Sulfate in Chronic Kidney Disease and Olfactory Dysfunction. , 37(1), 19-25. doi: 10.22038/ijorl.2024.77737.3632
Irnanda Warda Rizki Nasution; Tengku Siti Hajar Haryuna; Delfitri Munir; Syafrizal Nasution; Putri Chairani Eyanoer; Siti Nursiah; Ramlan Sitompul. "Correlation Between Indoxyl Sulfate in Chronic Kidney Disease and Olfactory Dysfunction". , 37, 1, 1403, 19-25. doi: 10.22038/ijorl.2024.77737.3632
Nasution, Irnanda, Haryuna, Tengku Siti, Munir, Delfitri, Nasution, Syafrizal, Eyanoer, Putri, Nursiah, Siti, Sitompul, Ramlan. (1403). 'Correlation Between Indoxyl Sulfate in Chronic Kidney Disease and Olfactory Dysfunction', , 37(1), pp. 19-25. doi: 10.22038/ijorl.2024.77737.3632
Nasution, Irnanda, Haryuna, Tengku Siti, Munir, Delfitri, Nasution, Syafrizal, Eyanoer, Putri, Nursiah, Siti, Sitompul, Ramlan. Correlation Between Indoxyl Sulfate in Chronic Kidney Disease and Olfactory Dysfunction. , 1403; 37(1): 19-25. doi: 10.22038/ijorl.2024.77737.3632

Correlation Between Indoxyl Sulfate in Chronic Kidney Disease and Olfactory Dysfunction

Iranian Journal of Otorhinolaryngology
دوره 37، شماره 1، فروردین و اردیبهشت 2025، صفحه 19-25    اصل مقاله (257.9 K)
نوع مقاله: Original
شناسه دیجیتال (DOI): 10.22038/ijorl.2024.77737.3632
نویسندگان
Irnanda Warda Rizki Nasution1؛ Tengku Siti Hajar Haryuna* 1؛ Delfitri Munir1؛ Syafrizal Nasution2؛ Putri Chairani Eyanoer3؛ Siti Nursiah1؛ Ramlan Sitompul1
1Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine, Universitas Sumatera Utara, Jl. Dr. Mansur No. 5, Medan, 20155, INDONESIA.
2Department of Internal Medicine, Faculty of Medicine, Universitas Sumatera Utara, Jl. Dr. Mansur No. 5, Medan 20155, INDONESIA
3Department of Community Medicine, Faculty of Medicine, Universitas Sumatera, Utara, Jl. Dr. Mansur No. 5, Medan, 20155, INDONESIA.
چکیده
Introduction:
Olfactory dysfunction is prevalent among individuals with chronic kidney disease (CKD), with prevalence escalating alongside disease severity. The uremic toxin we observed in this study is Indoxyl sulfate (IS), a potent uremic toxin that markedly accumulates in the plasma of patients with chronic insufficiency. Olfactory damage may occur in the setting of neuronal damage due to renal failure.
 
Materials and Methods:
27 patients, a total sample in this study with diagnosed chronic kidney disease within stage 5 on regular hemodialysis, were examined for indoxyl sulfate levels in blood plasma and then examined for their olfactory function using the Sniffin’ Sticks test. A correlation analysis was conducted between indoxyl sulfate levels and olfactory function test results in patients with CKD.
 
Results:
The Pearson correlation test revealed a strong, significant negative correlation between indoxyl sulfate levels and olfactory function (r = -0.613; p = 0.001). Additionally, correlations were found between indoxyl sulfate levels and each component of olfactory function: threshold value (r = -0.408; p = 0.035), discrimination (r = -0.807; p = 0.001), and identification (r = -0.703; p = 0.001).
 
Conclusion:
Olfactory function is compromised in individuals with chronic renal disease and correlates with the level of accumulation of the uremic toxin indoxyl sulfate.
کلیدواژه‌ها
Chronic kidney disease؛ Indoxyl sulfate؛ Olfactory dysfunction؛ Sniffin’ stick test Received date: 18 Mar 2024
مراجع
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