سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Asci, Halil, Akin, Suleyman Emre, Camas, Hasan Ekrem, Bindal, Ahmet, Kurtbolat, Okan, Tasan, Şerife, Gulal, Abdurrahman, Taner, Rumeysa, Kurt, Turgut, Ozmen, Ozlem. (1403). Investigating the protective effects of fluvoxamine against sepsis-related acute lung injury through antiapoptotic, anti-inflammatory, and anti-oxidant features in rats. , 28(3), 323-331. doi: 10.22038/ijbms.2024.80608.17444
Halil Asci; Suleyman Emre Akin; Hasan Ekrem Camas; Ahmet Bindal; Okan Kurtbolat; Şerife Tasan; Abdurrahman Gulal; Rumeysa Taner; Turgut Kurt; Ozlem Ozmen. "Investigating the protective effects of fluvoxamine against sepsis-related acute lung injury through antiapoptotic, anti-inflammatory, and anti-oxidant features in rats". , 28, 3, 1403, 323-331. doi: 10.22038/ijbms.2024.80608.17444
Asci, Halil, Akin, Suleyman Emre, Camas, Hasan Ekrem, Bindal, Ahmet, Kurtbolat, Okan, Tasan, Şerife, Gulal, Abdurrahman, Taner, Rumeysa, Kurt, Turgut, Ozmen, Ozlem. (1403). 'Investigating the protective effects of fluvoxamine against sepsis-related acute lung injury through antiapoptotic, anti-inflammatory, and anti-oxidant features in rats', , 28(3), pp. 323-331. doi: 10.22038/ijbms.2024.80608.17444
Asci, Halil, Akin, Suleyman Emre, Camas, Hasan Ekrem, Bindal, Ahmet, Kurtbolat, Okan, Tasan, Şerife, Gulal, Abdurrahman, Taner, Rumeysa, Kurt, Turgut, Ozmen, Ozlem. Investigating the protective effects of fluvoxamine against sepsis-related acute lung injury through antiapoptotic, anti-inflammatory, and anti-oxidant features in rats. , 1403; 28(3): 323-331. doi: 10.22038/ijbms.2024.80608.17444

Investigating the protective effects of fluvoxamine against sepsis-related acute lung injury through antiapoptotic, anti-inflammatory, and anti-oxidant features in rats

Iranian Journal of Basic Medical Sciences
مقاله 7، دوره 28، شماره 3، خرداد 2025، صفحه 323-331    اصل مقاله (500.1 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2024.80608.17444
نویسندگان
Halil Asci1، 2؛ Suleyman Emre Akin3؛ Hasan Ekrem Camas3؛ Ahmet Bindal4؛ Okan Kurtbolat1؛ Şerife Tasan5؛ Abdurrahman Gulal6؛ Rumeysa Taner2؛ Turgut Kurt7؛ Ozlem Ozmen* 5
1Department of Pharmacology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey
2Department of Bioengineering, Institute of Science and Technology, Suleyman Demirel University Isparta, Turkey
3Department of Thoracic Surgery, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey
4Department of Anesthesiology and Reanimation, Suleyman Demirel University, Isparta, Turkey
5Department of Pathology, Faculty of Veterinary Medicine, Burdur Mehmet Akif Ersoy University, Burdur, Turkey
6Veterinarian, Isparta, Turkey
7Veterinary Technician, Faculty of Medicine, Suleyman Demirel University Isparta, Turkey
چکیده
Objective(s): Acute lung injury (ALI) is characterized by severe hypoxia and alveolar damage, often caused by oxidative stress, endoplasmic reticulum stress (ERS), and apoptosis. Fluvoxamine (FLV), an antidepressant, has tissue-protective properties through various intracellular mechanisms. This study investigates the anti-inflammatory effects of  FLV used as an antidepressant in a lipopolysaccharide (LPS)-induced ALI model.
Materials and Methods: Thirty-two female Wistar Albino rats aged 14–16 weeks and weighing 300–350 g, with 8 animals in each group, were divided into four groups: control, LPS, LPS+FLV, and FLV. After LPS administration, rats were euthanized, and histopathological analysis, immunohistochemistry for tumor necrosis factor-α (TNF-α) and caspase-3 (Cas-3), ELISA for oxidative stress markers, and PCR for CHOP, Cas-12, and Cas-9 gene expressions were conducted.
Results: In the LPS group, lung tissue damage, increased inflammatory cell infiltration, increased Cas-3 and TNF-α expressions, increased oxidative stress markers, and increased CHOP, Cas-9, and Cas-12 mRNA expressions were observed compared to the control group. FLV treatment in the LPS+FLV group significantly reversed these effects in the LPS group.
Conclusion: FLV exhibits protective effects against ALI by mitigating inflammation, ERS, and apoptosis via the CHOP/Cas-9/Cas-12 pathway. Further studies are needed to explore additional pathways and potential clinical applications of FLV.
کلیدواژه‌ها
ER stress؛ Inflammation؛ Lipopolysaccharide؛ Rat؛ Respiratory system؛ SSRI
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