Effects of sumac aqueous extract along with eating and drinking modification on functional dyspepsia symptoms in comparison with omeprazole: An open-label, randomized, controlled clinical trial | ||
| Avicenna Journal of Phytomedicine | ||
| دوره 15، شماره 3، مرداد و شهریور 2025، صفحه 1147-1166 اصل مقاله (1.17 M) | ||
| نوع مقاله: Original Research Article | ||
| شناسه دیجیتال (DOI): 10.22038/ajp.2024.25239 | ||
| نویسندگان | ||
| Mahdi Saravani1؛ Zahra memariani2؛ Nasser Behnampour3؛ Mohammadreza Seyyedmajidi1؛ fatemeh kolangi* 4 | ||
| 1Golestan Research Center of Gastroenterology and Hepatology, Department of Persian Medicine, School of Persian Medicine, Golestan University of Medical Sciences, Gorgan, Iran. | ||
| 2Traditional Medicine and History of Medical Sciences Research Center, Health Research Institute, Department of History of Medical Sciences, School of Persian Medicine, Babol University of Medical Sciences, Babol,IR Iran. | ||
| 3Biostatistics Department,Faculty of Health,Golestan University of Medical Sciences,Gorgan, Iran | ||
| 4Counseling and Reproductive Health Research Centre, Department of Persian Medicine, School of medicine, Golestan University of Medical Sciences, Gorgan, Iran. | ||
| چکیده | ||
| Objective: Functional dyspepsia (FD), a common gastrointestinal problem. The aim of the study was to evaluate the influence of Rhus coriaria L. (sumac) on FD. Materials and Methods: This randomized controlled clinical trial study included 104 patients aged 18 to 60 years diagnosed with FD according to the ROME IV criteria. Four groups were formed: A) sumac extract + dietary changes, B) dietary changes, C) sumac extract and D) omeprazole. During the present eight-week study, patients' FD symptoms were assessed using the Gastrointestinal Symptom Rating Scale (GSRS) in four sessions. The Nepean Dyspepsia Index (NDI-10) was used to measure the impact of the interventions on patients' quality of life. Results: The study employed generalized estimating equation (GEE) analysis and found that symptom severity decreased across all groups during the intervention period. At the fourth week, no notable difference was noted between the omeprazole group and others. After the intervention, the severity of symptoms increased, especially in the omeprazole group, resulting in a significant difference compared to other groups. Conclusion: It seems that as a complementary treatment in FD, sumac might be effective with a more lasting effect with a significantly less recurrence of symptoms. | ||
| کلیدواژهها | ||
| Functional dyspepsia؛ Persian medicine؛ sumac؛ Rhus coriaria L؛ Quality of life | ||
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