سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Cakmak, Fatma, Kucukler, Sefa, Gur, Cihan, Ileriturk, Mustafa, Gul, Murat, Varisli, Behcet. (1403). Cardiotoxicity caused by acrylamide in rats can be alleviated as a result of suppression of oxidative stress, endoplasmic reticulum stress, inflammation, and apoptosis by morin treatment. , 28(3), 376-384. doi: 10.22038/ijbms.2024.81490.17634
Fatma Cakmak; Sefa Kucukler; Cihan Gur; Mustafa Ileriturk; Murat Gul; Behcet Varisli. "Cardiotoxicity caused by acrylamide in rats can be alleviated as a result of suppression of oxidative stress, endoplasmic reticulum stress, inflammation, and apoptosis by morin treatment". , 28, 3, 1403, 376-384. doi: 10.22038/ijbms.2024.81490.17634
Cakmak, Fatma, Kucukler, Sefa, Gur, Cihan, Ileriturk, Mustafa, Gul, Murat, Varisli, Behcet. (1403). 'Cardiotoxicity caused by acrylamide in rats can be alleviated as a result of suppression of oxidative stress, endoplasmic reticulum stress, inflammation, and apoptosis by morin treatment', , 28(3), pp. 376-384. doi: 10.22038/ijbms.2024.81490.17634
Cakmak, Fatma, Kucukler, Sefa, Gur, Cihan, Ileriturk, Mustafa, Gul, Murat, Varisli, Behcet. Cardiotoxicity caused by acrylamide in rats can be alleviated as a result of suppression of oxidative stress, endoplasmic reticulum stress, inflammation, and apoptosis by morin treatment. , 1403; 28(3): 376-384. doi: 10.22038/ijbms.2024.81490.17634

Cardiotoxicity caused by acrylamide in rats can be alleviated as a result of suppression of oxidative stress, endoplasmic reticulum stress, inflammation, and apoptosis by morin treatment

Iranian Journal of Basic Medical Sciences
مقاله 13، دوره 28، شماره 3، خرداد 2025، صفحه 376-384    اصل مقاله (491.95 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2024.81490.17634
نویسندگان
Fatma Cakmak1؛ Sefa Kucukler2؛ Cihan Gur* 3؛ Mustafa Ileriturk4؛ Murat Gul5؛ Behcet Varisli* 6
1İstanbul Atlas University, Faculty of Medicine, Department of Emergency Medicine, İstanbul, Turkey
2Atatürk University, Faculty of Veterinary Medicine, Department of Biochemistry, Erzurum, Turkey
3Atatürk University, Vocational School of Health Services, Department of Medical Laboratory Techniques, Erzurum, Turkey
4Atatürk University, Horasan Vocational College, Department of Animal Science, Erzurum, Turkey
5Aksaray University, Faculty of Medicine, Department of Cardiology, Aksaray, Turkey
6Final Inernational University, Vocational School of Health Services, Cyprus, Turkey
چکیده
Objective(s): The present study investigated whether morin has a protective effect against ACR-induced cardiac toxicity.
Materials and Methods: In this study, oxidative stress, inflammation, endoplasmic reticulum stress (ERS), and apoptosis markers in heart tissues were analyzed by different methods after ACR (38.27 mg/kg) and morin (50 or 100 mg/kg) oral administration for ten days to Sprague Dawley rats.
Results: The data obtained showed that ACR induced lipid peroxidation by decreasing superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) enzyme activities, glutathione (GSH) levels and nuclear factor erythroid 2-related factor 2 (Nrf-2), heme oxygenase-1 (HO-1), NAD(P)H dehydrogenase quinone 1 (NQO1), glutamate-cysteine ligase modifier subunit (GCLM), and glutamate-cysteine ligase catalytic subunit (GCLC) gene expressions. On the other hand, these markers approached the control group levels after morin treatment. Moreover, morin suppressed ACR-induced inflammatory genes. Morin down-regulated the related genes by reducing the ERS, exacerbated after ACR administration. In addition, it was observed that B-cell lymphoma-2 (Bcl-2) associated X protein (Bax), caspase-3, and apoptotic peptidase activating factor 1 (apaf-1) expressions, elevated by ACR in the heart tissue, were suppressed after morin administration. Moreover, Bcl-2 expression was triggered by morin treatment. Thus, morin suppressed ACR-induced apoptosis. 
Conclusion: Taken together, morin may protect against ACR-induced cardiac injury by suppressing oxidative stress, inflammation, ERS, and apoptosis.
کلیدواژه‌ها
Apoptosis؛ Acrylamide؛ Cardiotoxicity؛ Endoplasmic reticulum- stress؛ Morin
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