Atorvastatin and flaxseed dietary treatments improve dyslipidemia and liver injuries in a diet-induced rat model of non-alcoholic fatty liver disease | ||
| Avicenna Journal of Phytomedicine | ||
| دوره 15، شماره 3، مرداد و شهریور 2025، صفحه 1102-1112 اصل مقاله (820.9 K) | ||
| نوع مقاله: Short communication | ||
| شناسه دیجیتال (DOI): 10.22038/ajp.2024.25220 | ||
| نویسندگان | ||
| Zahra Eslami1؛ Hamidreza Joshaghani2؛ Abdorreza Eghbal Moghanlou3؛ Alireza Norouzi4؛ Seyed Javad Mirghani* 5 | ||
| 1Department of Clinical Biochemistry, Hamadan university of medical science, Hamadan, Iran. | ||
| 2Laboratory sciences research center, Golestan University of Medical Sciences, Gorgan, Iran | ||
| 3Istanbul esenyurt University, Physical Education and Sports High School, Coaching Education Department, Istanbul, Turkey | ||
| 4Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran | ||
| 5Shahid Mirghani Research Institute, Gorgan, Golestan, Iran | ||
| چکیده | ||
| Objective: Non-alcoholic fatty liver disease (NAFLD) as the most common chronic liver disease is associated with metabolic disorders including dysregulated lipid and glucose metabolism. There is no approved drug treatment for NAFLD; thus, new therapies are needed. We studied the antidyslipidemic effects of atorvastatin and/or possibly hepatoprotective effects of flaxseed/ flaxseed oil in a rat model of NAFLD. Materials and Methods: Fifty-six male Wistar rats were divided randomly into seven groups: 1) control, 2) high-fructose diet (HFD), 3) HFD +atorvastatin (20 mg/kg), 4) HFD+ flaxseed (40 g/kg), 5) HFD+ flaxseed oil (40 mg/kg), 6) HFD+flaxseed (40 g/kg) + atorvastatin (20 mg/kg) and 7) HFD+flaxseed oil (40 g/kg) +atorvastatin (20 mg/kg). The interventions were done for 23 weeks, after which anthropometric indices, lipid profile, liver enzymes, fasting blood glucose, and kidney indices were analyzed. Scoring of hematoxylin-eosin-stained liver sections was used to assess the severity of NAFLD. Results: All the treatments reduced mesenteric fat mass, and the amount of fat around the liver, except in HFD+ flaxseed +atorvastatin group. The interventions improved NAFLD activity score, which considers steatosis, lobular inflammation, and hepatocyte ballooning. However, atorvastatin was most efficient in reducing inflammation and hepatocyte ballooning. While atorvastatin reduced only Gamma-glutamyltransferase (GGT) levels, flaxseed or flaxseed oil mono- and combination therapies reduced serum levels of all liver enzymes. The interventions improved the serum lipid profile and all, except atorvastatin decreased fasting blood glucose. Conclusion: Flaxseed therapies improved NAFLD-associated liver injuries and dyslipidemia, while atorvastatin mostly reduced hepatocyte ballooning and lobular inflammation. | ||
| کلیدواژهها | ||
| Statin؛ Flax؛ Liver؛ Linseed Oil؛ Steatosis | ||
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