سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Soudkhah, Sevil, Keyghobadi, Sahar, Shadboorestan, Amir, Gholami, Mahdi, Omidi Sarajar, Behnam, Salek Maghsoudi, Armin, Omidi, Mahmoud, Mohammadi Motamed, Saeed, Akbarzadeh Kolahi, Saeid, Rastegar-Pouyani, Nima, Hassani, Shokoufeh. (1404). The hydroalcoholic extract of Nasturtium officinale protectively inhibits apoptotic and inflammatory pathways in hepato- and nephrotoxicity: An in vivo study. , 15(3), 1177-1192. doi: 10.22038/ajp.2024.25213
Sevil Soudkhah; Sahar Keyghobadi; Amir Shadboorestan; Mahdi Gholami; Behnam Omidi Sarajar; Armin Salek Maghsoudi; Mahmoud Omidi; Saeed Mohammadi Motamed; Saeid Akbarzadeh Kolahi; Nima Rastegar-Pouyani; Shokoufeh Hassani. "The hydroalcoholic extract of Nasturtium officinale protectively inhibits apoptotic and inflammatory pathways in hepato- and nephrotoxicity: An in vivo study". , 15, 3, 1404, 1177-1192. doi: 10.22038/ajp.2024.25213
Soudkhah, Sevil, Keyghobadi, Sahar, Shadboorestan, Amir, Gholami, Mahdi, Omidi Sarajar, Behnam, Salek Maghsoudi, Armin, Omidi, Mahmoud, Mohammadi Motamed, Saeed, Akbarzadeh Kolahi, Saeid, Rastegar-Pouyani, Nima, Hassani, Shokoufeh. (1404). 'The hydroalcoholic extract of Nasturtium officinale protectively inhibits apoptotic and inflammatory pathways in hepato- and nephrotoxicity: An in vivo study', , 15(3), pp. 1177-1192. doi: 10.22038/ajp.2024.25213
Soudkhah, Sevil, Keyghobadi, Sahar, Shadboorestan, Amir, Gholami, Mahdi, Omidi Sarajar, Behnam, Salek Maghsoudi, Armin, Omidi, Mahmoud, Mohammadi Motamed, Saeed, Akbarzadeh Kolahi, Saeid, Rastegar-Pouyani, Nima, Hassani, Shokoufeh. The hydroalcoholic extract of Nasturtium officinale protectively inhibits apoptotic and inflammatory pathways in hepato- and nephrotoxicity: An in vivo study. , 1404; 15(3): 1177-1192. doi: 10.22038/ajp.2024.25213

The hydroalcoholic extract of Nasturtium officinale protectively inhibits apoptotic and inflammatory pathways in hepato- and nephrotoxicity: An in vivo study

Avicenna Journal of Phytomedicine
دوره 15، شماره 3، مرداد و شهریور 2025، صفحه 1177-1192    اصل مقاله (1.54 M)
نوع مقاله: Original Research Article
شناسه دیجیتال (DOI): 10.22038/ajp.2024.25213
نویسندگان
Sevil Soudkhah1؛ Sahar Keyghobadi1؛ Amir Shadboorestan2؛ Mahdi Gholami3؛ Behnam Omidi Sarajar4؛ Armin Salek Maghsoudi3؛ Mahmoud Omidi5؛ Saeed Mohammadi Motamed6؛ Saeid Akbarzadeh Kolahi1؛ Nima Rastegar-Pouyani* 3؛ Shokoufeh Hassani7
1Department of Pharmacology and Toxicology, Faculty of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
2Department of Toxicology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
3Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences (TUMS), Tehran, Iran
4Department of toxicology and pharmacology, faculty of pharmacy,Tehran university of medical sciences,Tehran,Iran
5Department of Toxicology and Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Hormozgan University of Medical Sciences
6department of Pharmacognosy, Pharmaceutical sciences Branch, islamic Azad University, Tehran, Iran
7Toxicology and Diseases Group (TDG), Pharmaceutical Sciences Research Center (PSRC), Tehran University of Medical Sciences (TUMS), Tehran, Iran.
چکیده
Objective: Nasturtium officinale (N. officinale (NO)) has been widely used in traditional medicine. This study investigates the protective effects of NO against hepatic and renal damage induced by CCl4 and gentamicin, respectively, in rats.
Materials and Methods: Male Wistar rats were divided into two arms: A (CCl4-induced hepatotoxicity) and B (gentamicin-induced nephrotoxicity). Seventeen groups were formed by dividing arms A and B, with nine groups in arm A and eight groups in arm B (n=5). Rats were daily treated with various doses (50, 100, and 200 mg/kg BW) of N. officinale extract (NOE) (Total extract; Oral gavage) for 14 and 28 days in arm A and B, respectively. Biochemical and histopathological evaluations and gene expression analyses were conducted on blood, liver, and kidney tissues.
Results: NOE treatment significantly modulated B-cell lymphoma protein 2 (Bcl-2)-associated X (Bax) and B-cell lymphoma protein 2 (Bcl-2) expression in kidney tissue, reducing Bax (p<0.01) and increasing Bcl-2 (p<0.05). In liver tissue, NOE inhibited tumor necrosis factor alpha (TNF-α) (p<0.01) and Interleukin-1 beta (IL-1β) (p<0.001), while reducing AST and ALT activity (p<0.001). Additionally, blood urea nitrogen (BUN) levels significantly decreased (p<0.05) in nephrotoxic rats.
Conclusion: Our findings highlight the capability of NOE as a promising therapeutic against liver and kidney damage induced by CCl4 and gentamicin, respectively, in animal models.
کلیدواژه‌ها
Nephrotoxicity؛ Hepatotoxicity؛ Nasturtium officinale؛ Inflammation؛ Apoptosis
آمار
تعداد مشاهده مقاله: 363
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