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Omran, Ahmed, Abd El Wahab, Radwa, Zekry, Osama. (1403). Maternal and Neonatal Vitamin D Deficiency Associated with an Increased Risk of Neonatal Hypoxic Ischemic Encephalopathy. , 12(5), 18817-18822. doi: 10.22038/ijp.2024.70701.5199
Ahmed Omran; Radwa Abd El Wahab; Osama Zekry. "Maternal and Neonatal Vitamin D Deficiency Associated with an Increased Risk of Neonatal Hypoxic Ischemic Encephalopathy". , 12, 5, 1403, 18817-18822. doi: 10.22038/ijp.2024.70701.5199
Omran, Ahmed, Abd El Wahab, Radwa, Zekry, Osama. (1403). 'Maternal and Neonatal Vitamin D Deficiency Associated with an Increased Risk of Neonatal Hypoxic Ischemic Encephalopathy', , 12(5), pp. 18817-18822. doi: 10.22038/ijp.2024.70701.5199
Omran, Ahmed, Abd El Wahab, Radwa, Zekry, Osama. Maternal and Neonatal Vitamin D Deficiency Associated with an Increased Risk of Neonatal Hypoxic Ischemic Encephalopathy. , 1403; 12(5): 18817-18822. doi: 10.22038/ijp.2024.70701.5199

Maternal and Neonatal Vitamin D Deficiency Associated with an Increased Risk of Neonatal Hypoxic Ischemic Encephalopathy

Journal of Pediatric Perspectives
دوره 12، شماره 5، مرداد 2024، صفحه 18817-18822    اصل مقاله (198.41 K)
نوع مقاله: original article
شناسه دیجیتال (DOI): 10.22038/ijp.2024.70701.5199
نویسندگان
Ahmed Omran* ؛ Radwa Abd El Wahab؛ Osama Zekry
Departments of Pediatrics & Neonatology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
چکیده
Background: Neonatal Hypoxic-Ischemic Encephalopathy (HIE) remains a major cause of neonatal morbidity and mortality. Neonates are at a significantly high risk of vitamin D deficiency. Maternal and neonatal vitamin D deficiency is associated with multiple neonatal diseases including HIE. This study aims to explore the possible association between maternal and neonatal 25-hydroxy vitamin D (25-OHD) levels and HIE in full-term infants and it attempts to find whether there is any relationship between vitamin D level and the clinical severity of HIE.
Methods: This case-control study included 25 full-term neonates with HIE and their mothers along with 25 healthy neonates and their mothers. The level of serum (25-OHD) of the infants and their mothers was measured in the first 6 postnatal hours of the infants by isotope dilution ultra-performance liquid chromatography-tandem mass spectrometry. The severity of HIE was assessed depending on the clinical scoring system.
Results: Neonatal and maternal levels (25-OHD) were significantly lower in the study group compared with those of the control group. Neonatal (25-OHD) levels were significantly lower with increasing severity of HIE (p=0.005), but they did not follow the same order in the maternal (25-OHD) levels (p=0.96); i.e., a negative correlation was detected between neonatal (25-OHD) level and severity of HIE (r = − 0.66, P < 0.001). A positive correlation was found between neonatal and maternal (25-OHD) levels in the study group (r = 0.697, P < 0.001).
Conclusion: Lower maternal and neonatal vitamin D levels were associated with HIE in full-term infants and the level of vitamin D was inversely associated with the clinical severity of HIE. Further studies are needed to examine the causal relationship between vitamin D deficiency and HIE in neonates.
کلیدواژه‌ها
25-Hydroxyvitamin D؛ maternal؛ neonatal؛ hypoxic-ischemic encephalopathy؛ vitamin D deficiency
مراجع
  1. Kurinczuk JJ, White-Koning M, Badawi N. Epidemiology of neonatal encephalopathy and hypoxic–ischaemic encephalopathy. Early Hum Dev. 2010; 86(6):329–38.
  2. Fouda MA, Turkestani IZ, Almusharraf S, Al-Ajlan A, Angkaya-Bagayawa FF, Sabico S, et al. Extremely High Prevalence of Maternal and Neonatal Vitamin D Deficiency in the Arab Population. Neonatology. 2017; 112(3):225–30.
  3. Eyles D, Burne T, McGrath J. Vitamin D in fetal brain development. Semin Cell Dev Biol. 2011; 22(6):629–36.
  4. Fernandes de Abreu DA, Nivet E, Baril N, Khrestchatisky M, Roman F, Féron F. Developmental vitamin D deficiency alters learning in C57Bl/6J mice. Behav Brain Res. 2010; 208(2):603–8.
  5. Stessman LE, Peeples ES. Vitamin D and Its Role in Neonatal Hypoxic-Ischemic Brain Injury. Neonatology. 2018; 113:305–12.
  6. AlJohri R, AlOkail M, Haq SH: Neuroprotective role of vitamin D in primary neuronal cortical culture. eNeurologicalSci. 2019; 14(4):43–8.
  7. Mutlu M, Sarıaydın M, Aslan Y, Kader Ş, Dereci S, Kart C, et al. Status of vitamin D, antioxidant enzymes, and antioxidant substances in neonates with neonatal hypoxic-ischemic encephalopathy. J Matern Neonatal Med. 2015; 15(14); 1–5.
  8. Omran A, Mousa H, Abdalla MO, Zekry O. Maternal and neonatal vitamin D deficiency and transient tachypnea of the newborn in full term neonates. J Perinat Med. 2018; 27; 46(9):1057–60.
  9. Saboute M, Yavar R, Kashaki M, Khaledi FK, Khalesi N, Rohani F. Investigation of association between maternal 25-OH vitamin D serum levels and neonatal early onset sepsis in newborns by evaluating key factors. Lipids Health Dis. 2019; 13; 18(1):153.
  10. Shankaran S, Barnes PD, Hintz SR,Laptook AR, Zaterka-Baxter KM, McDonald SA, et al. Brain injury following trial of hypothermia for neonatal hypoxic-ischaemic encephalopathy. Arch Dis Child. 2012; 97(6):F398-404.
  11. Karras SN, Koufakis T, Antonopoulou V, Goulis DG, Annweiler C, Pilz S, et al. Characterizing neonatal vitamin D deficiency in the modern era: A maternal-neonatal birth cohort from Southern Europe. J Steroid Biochem Mol Biol. 2020; 198:105555.
  12. Lowe DW, Hollis BW, Wagner CL, Bass T, Kaufman DA, Horgan MJ, et al.: Vitamin D insufficiency in neonatal hypoxic–ischemic encephalopathy. Pediatr Res. 2017; 17; 82(1):55–62.
  13. Hagag AA, Frargy MS El, Abd El-Latif AE. Vitamin D as an Adjuvant Therapy in Neonatal Hypoxia: Is it Beneficial? Endocrine, Metab Immune Disord - Drug Targets. 2019; 15; 19(3):341–8.
  14. McGinn EA, Powers A, Galas M, Lyden E, Peeples ES. Neonatal Vitamin D Status Is Associated with the Severity of Brain Injury in Neonatal Hypoxic–Ischemic Encephalopathy: A Pilot Study. Neuropediatrics. 2020; 16; 51(4):251–8.
  15. Adams LE, Moss HG, Lowe DW, Brown T, Wiest DB, Hollis BW, et al. NAC and Vitamin D Restore CNS Glutathione in Endotoxin-Sensitized Neonatal Hypoxic-Ischemic Rats. Antioxidants. 2021; 20; 10(3):489.
 

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