سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Alipour, Mohammad, Shakhseniaei, Hanie, Moradi, Ali. (1403). The Hemostatic Effect of Tranexamic Acid during and after Total Knee Arthroplasty. , 12(3), 107-112. doi: 10.22038/psj.2024.79087.1428
Mohammad Alipour; Hanie Shakhseniaei; Ali Moradi. "The Hemostatic Effect of Tranexamic Acid during and after Total Knee Arthroplasty". , 12, 3, 1403, 107-112. doi: 10.22038/psj.2024.79087.1428
Alipour, Mohammad, Shakhseniaei, Hanie, Moradi, Ali. (1403). 'The Hemostatic Effect of Tranexamic Acid during and after Total Knee Arthroplasty', , 12(3), pp. 107-112. doi: 10.22038/psj.2024.79087.1428
Alipour, Mohammad, Shakhseniaei, Hanie, Moradi, Ali. The Hemostatic Effect of Tranexamic Acid during and after Total Knee Arthroplasty. , 1403; 12(3): 107-112. doi: 10.22038/psj.2024.79087.1428

The Hemostatic Effect of Tranexamic Acid during and after Total Knee Arthroplasty

Journal of Patient Safety & Quality Improvement
مقاله 1، دوره 12، شماره 3، مهر 2024، صفحه 107-112    اصل مقاله (322.34 K)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.22038/psj.2024.79087.1428
نویسندگان
Mohammad Alipour* 1؛ Hanie Shakhseniaei2؛ Ali Moradi3
1Department of Anesthesiology, Mashhad University of Medical Sciences, Mashhad, Iran.
2Clinical Research Development Unit, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
3Orthopedic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
چکیده
Introduction:
Total knee arthroplasty (TKA) is an effective treatment method for end-stage knee osteoarthritis, and with the aging population, the demand for this surgery has significantly increased. However, bleeding during and after TKA remains a major complication. Blood transfusion, while necessary in some cases, is associated with various complications. Therefore, finding measures to reduce the need for transfusion is crucial in minimizing postoperative complications.
Materials and Methods:
This study was conducted to review the world literature on The Hemostatic Effect of Tranexamic Acid during and after Total Knee Arthroplasty. In this review study, the terms total knee arthroplasty and tranexamic acid were searched in the title and abstract of articles published in internationally recognized scientific databases, and all English and related articles were listed.
Result:
Tranexamic acid, an antifibrinolytic agent, has shown promising results in reducing blood loss in major surgeries such as TKA. Different administration methods of tranexamic acid have been deemed effective, with the choice depending on the surgical team's preference and protocol.
Discussion:
Several studies have demonstrated the efficacy of tranexamic acid in reducing bleeding during and after TKA, leading to a decreased need for blood transfusion and its associated complications. Additionally, tranexamic acid has been found to improve joint function post-surgery in TKA patients. Overall, tranexamic acid represents a valuable option in managing bleeding in TKA procedures, offering potential benefits in reducing transfusion requirements and improving patient outcomes.
کلیدواژه‌ها
Bleeding؛ Tranexamic acid؛ Total knee arthroplasty
مراجع
  1. Curnow J, Pasalic L, Favaloro EJ. Why do patients bleed? The Surgery Journal. 2016;2(01):e29-e43.
  2. Al-Attar N, Johnston S, Jamous N, Mistry S, Ghosh E, Gangoli G, et al. Impact of bleeding complications on length of stay and critical care utilization in cardiac surgery patients in England. J Cardiothorac Surg. 2019;14(1):64.
  3. Lutzner C, Beyer F, David L, Lutzner J. Fulfilment of patients' mandatory expectations are crucial for satisfaction: a study amongst 352 patients after total knee arthroplasty (TKA). Knee Surg Sports Traumatol Arthrosc. 2023;31(9):3755-64.
  4. Rivière C, Villet L, Jeremic D, Vendittoli P-A. What you need to know about kinematic alignment for total knee arthroplasty. Orthopaedics & Traumatology: Surgery & Research. 2021;107(1):1
  5. Hootman JM, Helmick CG, Barbour KE, Theis KA, Boring MA. Updated projected prevalence of self‐reported doctor‐diagnosed arthritis and arthritis‐attributable activity limitation among US adults, 2015–2040. Arthritis & rheumatology. 2016;68(7):1582-7.
  6. Palmer A, Chen A, Matsumoto T, Murphy M, Price A. Blood management in total knee arthroplasty: state-of-the-art review. Journal of ISAKOS. 2018;3(6):358-66.
  7. Moskal JT, Capps SG. Intra-articular tranexamic acid in primary total knee arthroplasty: meta-analysis. The journal of knee surgery. 2018;31(01):056-67.
  8. Liao L, Chen Y, Tang Q, Chen Y-y, Wang W-c. Tranexamic acid plus drain-clamping can reduce blood loss in total knee arthroplasty: a systematic review and meta-analysis. International Journal of Surgery. 2018;52:334-41.
  9. Helito CP, Bonadio MB, Sobrado MF, Giglio PN, Pécora JR, Camanho GL, et al. Comparison of floseal® and tranexamic acid for bleeding control after total knee arthroplasty: a prospective randomized study. Clinics. 2019;74.
  10. Li J, Li H-b, Zhai X-c, Jiang X-q, Zhang Z-h. Topical use of topical fibrin sealant can reduce the need for transfusion, total blood loss and the volume of drainage in total knee and hip arthroplasty: a systematic review and meta-analysis of 1489 patients. International journal of surgery. 2016;36:127-37.
  11. Yu Z, Yao L, Yang Q. Tranexamic acid plus diluted-epinephrine versus tranexamic acid alone for blood loss in total joint arthroplasty: A meta-analysis. Medicine. 2017;96(24).
  12. Tengborn L, Blombäck M, Berntorp E. Tranexamic acid–an old drug still going strong and making a revival. Thrombosis research. 2015;135(2):231-42.
  13. Diebel ME, Martin JV, Liberati DM, Diebel LN. The temporal response and mechanism of action of tranexamic acid in endothelial glycocalyx degradation. Journal of Trauma and Acute Care Surgery. 2018;84(1):75-80.
  14. Cai J, Ribkoff J, Olson S, Raghunathan V, Al‐Samkari H, DeLoughery TG, et al. The many roles of tranexamic acid: an overview of the clinical indications for TXA in medical and surgical patients. European journal of haematology. 2020;104(2):79-87.
  15. Lee SY, Chong S, Balasubramanian D, Na YG, Kim TK. What is the ideal route of administration of tranexamic acid in TKA? A randomized controlled trial. Clinical Orthopaedics and Related Research®. 2017;475:1987-96.
  16. Lin ZX, Woolf SK. Safety, efficacy, and cost-effectiveness of tranexamic acid in orthopedic surgery. Orthopedics. 2016;39(2):119-30.
  17. Almeida MDCd, Albuquerque RPe, Palhares GM, Almeida JPCd, Barretto JM, Cavanellas N. Evaluation of the use of tranexamic acid in total knee arthroplasty. Revista Brasileira de Ortopedia (English Edition). 2018;53(6):761-7.
  18. Lin C, Qi Y, Jie L, Li H-b, Zhao X-c, Qin L, et al. Is combined topical with intravenous tranexamic acid superior than topical, intravenous tranexamic acid alone and control groups for blood loss controlling after total knee arthroplasty: a meta-analysis. Medicine. 2016; 95(51).
  19. Lei Y, Xie J, Xu B, Xie X, Huang Q, Pei F. The efficacy and safety of multiple-dose intravenous tranexamic acid on blood loss following total knee arthroplasty: a randomized controlled trial. International orthopaedics. 2017;41:2053-9.
  20. Montroy J, Hutton B, Moodley P, Fergusson NA, Cheng W, Tinmouth A, et al. The efficacy and safety of topical tranexamic acid: a systematic review and meta-analysis. Transfus Med Rev. 2018; 32(3):165-78.
  21. Aggarwal AK, Singh N, Sudesh P. Topical vs intravenous tranexamic acid in reducing blood loss after bilateral total knee arthroplasty: a prospective study. The Journal of arthroplasty. 2016;31(7):1442-8.
  22. Jules-Elysee KM, Tseng A, Sculco TP, Baaklini LR, McLawhorn AS, Pickard AJ, et al. Comparison of topical and intravenous tranexamic acid for total knee replacement: a randomized double-blinded controlled study of effects on tranexamic acid levels and thrombogenic and inflammatory marker levels. The Journal of Bone and Joint Surgery American Volume. 2019;101(23):2120.
  23. Zekcer A, Priori RD, Tieppo C, Silva RSd, Severino NR. Comparative study of topical vs. intravenous tranexamic acid regarding blood loss in total knee arthroplasty. Revista brasileira de ortopedia. 2017;52:589-95.
  24. Wei W, Dang S, Duan D, Wei L. Comparison of intravenous and topical tranexamic acid in total knee arthroplasty. BMC Musculoskel Disord. 2018;19(1):191.
  25. Song E-K, Seon J-K, Prakash J, Seol Y-J, Park YJ, Jin C. Combined administration of IV and topical tranexamic acid is not superior to either individually in primary navigated TKA. The Journal of arthroplasty. 2017;32(1):37-42.
  26. Chalmers BP, Mishu M, Cushner FD, Sculco PK, Nguyen J, Westrich GH. Is there a synergistic effect of topical plus intravenous tranexamic acid versus intravenous administration alone on blood loss and transfusions in primary total hip and knee arthroplasties? Arthroplasty Today. 2021;7:194-9.
  27. Wang Z, Shen X. The efficacy of combined intra-articular and intravenous tranexamic acid for blood loss in primary total knee arthroplasty: A meta-analysis. Medicine. 2017;96(42).
  28. Zhang L-K, Ma J-X, Kuang M-J, Zhao J, Lu B, Wang Y, et al. The efficacy of tranexamic acid using oral administration in total knee arthroplasty: a systematic review and meta-analysis. Journal of Orthopaedic Surgery and Research. 2017;12(1):1-11.
  29. Alipour M, Tabari M, Keramati M, Zarmehri AM, Makhmalbaf H. Effectiveness of oral tranexamic acid administration on blood loss after knee artroplasty: a randomized clinical trial. Transfusion and Apheresis Science. 2013; 49(3): 574-7.
  30. Yuan X, Li B, Wang Q, Zhang X. Comparison of 3 routes of administration of tranexamic acid on primary unilateral total knee arthroplasty: a prospective, randomized, controlled study. The Journal of arthroplasty. 2017;32(9):2738-43.
  31. King L, Randle R, Dare W, Bernaitis N. Comparison of oral vs. combined topical/ intravenous/oral tranexamic acid in the prevention of blood loss in total knee arthroplasty: a randomised clinical trial. Orthopaedics & Traumatology: Surgery & Research. 2019;105(6):1073-7.
آمار
تعداد مشاهده مقاله: 235
تعداد دریافت فایل اصل مقاله: 95