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Rahimi, Mitra, Abouei Mehrizi, Sarina, Shadnia, Shahin, Mostafazadeh, Babak, Erfantalab, Peyman. (1403). A rare case of cumulative methanol poisoning caused vision loss after 14 days. , 13(2), 81-83. doi: 10.22038/apjmt.2024.80269.1458
Mitra Rahimi; Sarina Abouei Mehrizi; Shahin Shadnia; Babak Mostafazadeh; Peyman Erfantalab. "A rare case of cumulative methanol poisoning caused vision loss after 14 days". , 13, 2, 1403, 81-83. doi: 10.22038/apjmt.2024.80269.1458
Rahimi, Mitra, Abouei Mehrizi, Sarina, Shadnia, Shahin, Mostafazadeh, Babak, Erfantalab, Peyman. (1403). 'A rare case of cumulative methanol poisoning caused vision loss after 14 days', , 13(2), pp. 81-83. doi: 10.22038/apjmt.2024.80269.1458
Rahimi, Mitra, Abouei Mehrizi, Sarina, Shadnia, Shahin, Mostafazadeh, Babak, Erfantalab, Peyman. A rare case of cumulative methanol poisoning caused vision loss after 14 days. , 1403; 13(2): 81-83. doi: 10.22038/apjmt.2024.80269.1458

A rare case of cumulative methanol poisoning caused vision loss after 14 days

Asia Pacific Journal of Medical Toxicology
مقاله 7، دوره 13، شماره 2، شهریور 2024، صفحه 81-83    اصل مقاله (282.64 K)
نوع مقاله: Case Report
شناسه دیجیتال (DOI): 10.22038/apjmt.2024.80269.1458
نویسندگان
Mitra Rahimi1؛ Sarina Abouei Mehrizi2؛ Shahin Shadnia1؛ Babak Mostafazadeh1؛ Peyman Erfantalab* 1
1Toxicological Research Center, Excellence Center of Clinical Toxicology, Department of Clinical Toxicology, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2School of Medicine, Islamic Azad University, Tehran, Iran
چکیده
Background: The following case report discusses a person who experienced vision loss after consuming a homemade alcoholic beverage for 14 days.
Case presentation: A 32-year-old Iranian man with a chief complaint of blindness was referred to Loghman Hakim Hospital.
Results: The patient's visual acuity was limited to light perception, meaning he could only identify the direction of the light. He had a history of purchasing a 20-liter batch of homemade alcoholic beverages, which he consumed over 14 days with various groups of friends. The day after he finished the drink and stopped consuming it, his vision started to deteriorate. By the end of the second day, he was nearly blind. None of his other friends who drank from the same alcohol were showing any visual or other symptoms of methanol poisoning problems. The liquor he purchased contained a small amount of methanol. While folinic acid detoxified it in his friends, it accumulated in him over two weeks of constant drinking. Because ethanol is a competitive inhibitor of methanol for the alcohol dehydrogenase (ADH) enzyme, the methanol was not converted.
Discussion: Methanol toxicity, a leading cause of blindness in developing nations, damages the optic nerve and retina by disrupting mitochondrial function through formic acid’s effect on cytochrome oxidase. ADH isoenzyme variations affect methanol elimination rates and delayed neurological syndromes, including vision problems.
Conclusion: Formic acid led to blindness. However, as his blood ethanol levels decreased, he began showing symptoms of methanol toxicity.
کلیدواژه‌ها
Ethanol؛ Methanol؛ Toxicity Handmade alcohol؛ Vision loss
مراجع
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