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Etemad, Leila, Ramezani, Yeganeh, Vahidi, Mina, Dadpour, Bita, Moshiri, Mohammad. (1403). The correlation between the length of hospital stay with APACHE and PSS scores in baclofen toxicity. , 13(2), 42-48. doi: 10.22038/apjmt.2024.80559.1461
Leila Etemad; Yeganeh Ramezani; Mina Vahidi; Bita Dadpour; Mohammad Moshiri. "The correlation between the length of hospital stay with APACHE and PSS scores in baclofen toxicity". , 13, 2, 1403, 42-48. doi: 10.22038/apjmt.2024.80559.1461
Etemad, Leila, Ramezani, Yeganeh, Vahidi, Mina, Dadpour, Bita, Moshiri, Mohammad. (1403). 'The correlation between the length of hospital stay with APACHE and PSS scores in baclofen toxicity', , 13(2), pp. 42-48. doi: 10.22038/apjmt.2024.80559.1461
Etemad, Leila, Ramezani, Yeganeh, Vahidi, Mina, Dadpour, Bita, Moshiri, Mohammad. The correlation between the length of hospital stay with APACHE and PSS scores in baclofen toxicity. , 1403; 13(2): 42-48. doi: 10.22038/apjmt.2024.80559.1461

The correlation between the length of hospital stay with APACHE and PSS scores in baclofen toxicity

Asia Pacific Journal of Medical Toxicology
مقاله 1، دوره 13، شماره 2، شهریور 2024، صفحه 42-48    اصل مقاله (385.75 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/apjmt.2024.80559.1461
نویسندگان
Leila Etemad1؛ Yeganeh Ramezani2؛ Mina Vahidi2؛ Bita Dadpour3؛ Mohammad Moshiri* 4، 5
1Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
2Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3Toxicology Department, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
4Department of Clinical Toxicology and poisoning, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
5Medical toxicology research center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Background: This is a descriptive cross-sectional study to investigate the severity of acute baclofen poisoning and length of hospital stay (LOS)
Methods: The documents of cases with baclofen poisoning diagnosis; Baclofen alone intoxication (BAI) and multidrug intoxication (MDI) (March 2015-2019) were evaluated. Clinical and paraclinical findings, LOS, APACHE, and Poison Severity Scores (PSS) were extracted.
Results: From 46 collected cases 10 cases were BAI and all of them were women. The adult cases who attempted suicide were younger (26.09±9.62 years) than those accidentally poisoned (58.29±22.06 years) (PV=0.008). Two BAI (20%) and one MDI (2.7%) were apnotic. None of BAI had hypotension, hypertension, bradycardia, or tachycardia. Past medical history of depression has no statistically significant effect on the clinical manifestation. There were correlations between adult diastolic and mean arterial blood pressures with baclofen ingested dose and renal function test results. MDI and BAI had similar ingested baclofen doses (152.63±67.0 and 130±90.3 mg). All BAI had GCS<10. The mean of the calculated APACHE score was higher in BAI (15.43±3.2) than in MDI (8.8±7.8) groups (PV<0.05). APACHE score positively correlated with the LOS of BAI (R2=0.830, b=0.287 CI=0.175-0.420; PV=0.001). APACHE score did not correlate with the estimated baclofen ingested dose. There is a positive linear correlation between PSS and APACHE score of BAI patients, (R2=0.499, PV=0.033, B=5.00±1.89, PV=0.033, CI=0.52-9.479). However, there was no correlation between PSS of BAI cases and LOS (PV=0.24).
Conclusion: The APACHE score had a positive correlation with the LOS.
کلیدواژه‌ها
Poisoning؛ Baclofen؛ Muscle Relaxants؛ APACHE؛ Treatment Outcome
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