سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

اشتاد, الهه, یعقوبی, عطیه, خزاعی, دکتر مجید. (1403). نقش میکروبیوتا بر سلامت باروری زنان: مکانیسم‌های دفاعی، پاتوژنز و اهمیت آن در چسبندگی رحم- مرور سیستماتیک. , 27(8), 81-100. doi: 10.22038/ijogi.2024.77392.5968
الهه اشتاد; عطیه یعقوبی; دکتر مجید خزاعی. "نقش میکروبیوتا بر سلامت باروری زنان: مکانیسم‌های دفاعی، پاتوژنز و اهمیت آن در چسبندگی رحم- مرور سیستماتیک". , 27, 8, 1403, 81-100. doi: 10.22038/ijogi.2024.77392.5968
اشتاد, الهه, یعقوبی, عطیه, خزاعی, دکتر مجید. (1403). 'نقش میکروبیوتا بر سلامت باروری زنان: مکانیسم‌های دفاعی، پاتوژنز و اهمیت آن در چسبندگی رحم- مرور سیستماتیک', , 27(8), pp. 81-100. doi: 10.22038/ijogi.2024.77392.5968
اشتاد, الهه, یعقوبی, عطیه, خزاعی, دکتر مجید. نقش میکروبیوتا بر سلامت باروری زنان: مکانیسم‌های دفاعی، پاتوژنز و اهمیت آن در چسبندگی رحم- مرور سیستماتیک. , 1403; 27(8): 81-100. doi: 10.22038/ijogi.2024.77392.5968

نقش میکروبیوتا بر سلامت باروری زنان: مکانیسم‌های دفاعی، پاتوژنز و اهمیت آن در چسبندگی رحم- مرور سیستماتیک

مجله زنان، مامایی و نازایی ایران
دوره 27، شماره 8، آبان 1403، صفحه 81-100    اصل مقاله (1.52 M)
نوع مقاله: مروری
شناسه دیجیتال (DOI): 10.22038/ijogi.2024.77392.5968
نویسندگان
الهه اشتاد1؛ عطیه یعقوبی2؛ دکتر مجید خزاعی* 3
1دانشجوی کارشناسی ارشد فیزیولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.
2دکترای میکروب‌شناسی، مدیریت امور آزمایشگاه‌های معاونت درمان، دانشگاه علوم پزشکی مشهد، مشهد، ایران.
3استاد گروه فیزیولوژی، مرکز تحقیقات سندرم متابولیک، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.
چکیده
مقدمه: حدود 9% از کل میکروبیوتا بدن، میکروبیوتای سیستم تولید مثل را تشکیل می­ دهد. میکروبیوتای دستگاه تناسلی زنان، نقش مهمی در سلامت و بیماری دارند. عدم تعادل در میکروبیوتای واژن، منجر به اختلالاتی از جمله چسبندگی داخل رحمی (IUA) می­ شود که نشانه‌­های بالینی معمول آن شامل آمنوره، ناباروری و درد لگنی است. مطالعه حاضر با هدف بررسی پژوهش­ هایی که نقش میکروبیوتای رحم را در سیستم دفاعی بدن، بیماری‌های مختلف و به‌خصوص نقش آن در پاتوژنز ایجاد چسبندگی رحم مطالعه کرده‌اند، انجام شد.
روش‌کار: در این مقاله مروری، مطالعات مربوط به میکروبیوتای واژن و چسبندگی ­های داخل رحمی در پایگاه داده‌های PubMed ،Scopus ،EMBASE ،Web of Knowledge ، SID و همچنین سیستم بررسی واژگان (Mesh) با استفاده از کلمات کلیدیVaginal Microbiota ،Uterine microbiota ،Intrauterine adhesions و Dysbiosis مورد جستجو قرار گرفتند.
یافته­ ها: میکروبیوتا از طریق مکانیسم­ های متعدد، نقش مهمی در فرآیندهای فیزیولوژیکی انسان از جمله متابولیسم بدن، التهاب، سیستم ایمنی و ... دارد. لاکتوباسیلوس، میکروبیوتای غالب دستگاه تناسلی، به حفظ محیط اسیدی که برای باکتری‌های مضر نامناسب است، کمک می‌کند. ترکیب میکروبیوتا می ­تواند تحت تأثیر عواملی مانند سن و هورمون تغییر کند و هر عاملی مانند استفاده غیرمنطقی آنتی‌بیوتیک‌ها، تعادل میکروبیوتا را مختل کرده و منجر به بیماری­ هایی مانند چسبندگی رحم شود.
نتیجه­ گیری: عدم تعادل در میکروبیوتای بدن از جمله در دستگاه تناسلی می‌تواند منجر به عوارضی مانند چسبندگی رحم شود. درک کامل مکانیسم و سازوکار عملکرد میکروبیوتای دستگاه تناسلی در ایجاد، درمان و پیشگیری از بیماری‌های زنان، نیازمند مطالعات بالینی بیشتری در آینده می‌باشد.
کلیدواژه‌ها
چسبندگی داخل رحمی؛ دیس‌بیوز؛ میکروبیوتا
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