Safety Evaluation of Crocin (a constituent of saffron) Tablets in Healthy Volunteers | ||
| Iranian Journal of Basic Medical Sciences | ||
| مقاله 4، دوره 16، شماره 1، فروردین 2013، صفحه 39-44 اصل مقاله (396.46 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22038/ijbms.2013.247 | ||
| نویسندگان | ||
| Amir Houshang Mohamadpour1؛ Zahara Ayati2؛ Mohammad–Reza Parizadeh2؛ Omid Rajbai2؛ Hossein Hosseinzadeh* 1 | ||
| 11Pharmaceutical Research Center, Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 22Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| چکیده | ||
| Objective(s): Crocin is the chemical ingredient primarily responsible for the color of saffron. It has different pharmacological effects such as antioxidant, anticancer and memory improving activities. Crocin tablets were evaluated for short-term safety and tolerability in healthy adult volunteers. Materials and Methods: The study was a randomized, double-blind, placebo-controlled design consisting of one month treatment of crocin tablets. Volunteers who fulfilled inclusion and exclusion criteria were randomized into 2 groups of 22 each (males and females) and received 20 mg crocin tablets or placebo. General measures of health were recorded during the study such as hematological, biochemical, hormonal and urinary parameters in pre and post-treatment periods. Results: No major adverse events were reported during the trial. Crocin tablets did not change the above parameters except that it decreased amylase, mixed white blood cells and PTT in healthy volunteers after one month. Conclusion: This clinical safety evaluation showed a relatively safe and normal profile for crocin in healthy volunteers at the given doses within the trial period. | ||
| کلیدواژهها | ||
| Clinical trial؛ Crocin؛ Crocus sativus؛ Human volunteers؛ Safety assessment؛ Saffron | ||
| مراجع | ||
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