Ali, Asad, Emad, Nasr, Sultana, Niha, Ali, Hamad, Jahan, Samreen, Aqil, Mohd, Mujeeb, Mohd, Sultana, Yasmin. (1403). Medicinal potential of embelin and its nanoformulations: An update on the molecular mechanism and various applications. , 27(10), 1228-1242. doi: 10.22038/ijbms.2024.77888.16850
Asad Ali; Nasr Ali Emad; Niha Sultana; Hamad Ali; Samreen Jahan; Mohd Aqil; Mohd Mujeeb; Yasmin Sultana. "Medicinal potential of embelin and its nanoformulations: An update on the molecular mechanism and various applications". , 27, 10, 1403, 1228-1242. doi: 10.22038/ijbms.2024.77888.16850
Ali, Asad, Emad, Nasr, Sultana, Niha, Ali, Hamad, Jahan, Samreen, Aqil, Mohd, Mujeeb, Mohd, Sultana, Yasmin. (1403). 'Medicinal potential of embelin and its nanoformulations: An update on the molecular mechanism and various applications', , 27(10), pp. 1228-1242. doi: 10.22038/ijbms.2024.77888.16850
Ali, Asad, Emad, Nasr, Sultana, Niha, Ali, Hamad, Jahan, Samreen, Aqil, Mohd, Mujeeb, Mohd, Sultana, Yasmin. Medicinal potential of embelin and its nanoformulations: An update on the molecular mechanism and various applications. , 1403; 27(10): 1228-1242. doi: 10.22038/ijbms.2024.77888.16850

Medicinal potential of embelin and its nanoformulations: An update on the molecular mechanism and various applications

Iranian Journal of Basic Medical Sciences
مقاله 2، دوره 27، شماره 10، دی 2024، صفحه 1228-1242    اصل مقاله (1012.66 K)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2024.77888.16850
نویسندگان
Asad Ali1؛ Nasr Ali Emad1؛ Niha Sultana1؛ Hamad Ali2؛ Samreen Jahan1؛ Mohd Aqil* 1؛ Mohd Mujeeb2؛ Yasmin Sultana1
1Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi-110062, India
2Department of Phytochemistry and Pharmacognosy, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi-110062, India
چکیده
Natural herbs have garnered significant research recently as their components target multiple disease signaling pathways, making them highly potential for various disease prevention and treatment. Embelin, a naturally occurring benzoquinone isolated from Embelia ribes, has shown promising biological activities such as antitumor, antidiabetic, anti-oxidant, and antimicrobial. Various mechanisms have been reported, including monitoring genes that synchronize the cell cycle, up-regulating multiple anti-oxidant enzymes, suppressing genes that prevent cell death, influencing transcription factors, and preventing inflammatory biomarkers. However, the hydrophobic nature of embelin leads to poor absorption and limits its therapeutic potential. This review highlights a wide range of nanocarriers used as delivery systems for embelin, including polymeric nanoparticles, liposomes, nanostructured lipid carriers, micelles, nanoemulsion, and metallic nanoparticles. These embelin nanomedicine formulations have been developed in preclinical studies as a possible treatment for many disorders and characterized using various in vitro, ex vivo, and in vivo models.
کلیدواژه‌ها
Embelin؛ Nanoparticles؛ Pharmacokinetics؛ Pharmacologic actions؛ Structure-activity- relationship
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آمار
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