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Yada, Nobuhiro, Kuroda, Hiroyuki, Kawamura, Toshihiko, Fukuda, Mizuki, Miyahara, Yoshinori, Yoshizako, Takeshi, Kaji, Yasushi. (1403). Improvement of image quality for small lesion sizes in 18F-FDG prone breast silicon photomultiplier-based PET/CT imaging. , 13(1), 77-86. doi: 10.22038/aojnmb.2024.78080.1553
Nobuhiro Yada; Hiroyuki Kuroda; Toshihiko Kawamura; Mizuki Fukuda; Yoshinori Miyahara; Takeshi Yoshizako; Yasushi Kaji. "Improvement of image quality for small lesion sizes in 18F-FDG prone breast silicon photomultiplier-based PET/CT imaging". , 13, 1, 1403, 77-86. doi: 10.22038/aojnmb.2024.78080.1553
Yada, Nobuhiro, Kuroda, Hiroyuki, Kawamura, Toshihiko, Fukuda, Mizuki, Miyahara, Yoshinori, Yoshizako, Takeshi, Kaji, Yasushi. (1403). 'Improvement of image quality for small lesion sizes in 18F-FDG prone breast silicon photomultiplier-based PET/CT imaging', , 13(1), pp. 77-86. doi: 10.22038/aojnmb.2024.78080.1553
Yada, Nobuhiro, Kuroda, Hiroyuki, Kawamura, Toshihiko, Fukuda, Mizuki, Miyahara, Yoshinori, Yoshizako, Takeshi, Kaji, Yasushi. Improvement of image quality for small lesion sizes in 18F-FDG prone breast silicon photomultiplier-based PET/CT imaging. , 1403; 13(1): 77-86. doi: 10.22038/aojnmb.2024.78080.1553

Improvement of image quality for small lesion sizes in 18F-FDG prone breast silicon photomultiplier-based PET/CT imaging

Asia Oceania Journal of Nuclear Medicine and Biology
مقاله 9، دوره 13، شماره 1، فروردین 2025، صفحه 77-86    اصل مقاله (1.55 M)
نوع مقاله: Technical note
شناسه دیجیتال (DOI): 10.22038/aojnmb.2024.78080.1553
نویسندگان
Nobuhiro Yada* 1؛ Hiroyuki Kuroda2؛ Toshihiko Kawamura3؛ Mizuki Fukuda1؛ Yoshinori Miyahara1؛ Takeshi Yoshizako2؛ Yasushi Kaji2
1Department of Radiology, Shimane University Hospital, Izumo, Japan
2Department of Radiology, Faculty of Medicine, Shimane University, Izumo, Japan
3Division of Medical Informatics, Shimane University Hospital, Izumo, Japan
چکیده
Objective(s): We investigated image quality and standardized uptake values (SUVs) for different lesion sizes using clinical data generated by 18F-FDG-prone breast silicon photomultiplier (SiPM)-based positron emission tomography/computed tomography (PET/CT).
Methods: We evaluated the effect of point-spread function (PSF) modeling and Gaussian filtering (Gau) and determined the optimal reconstruction conditions. We compared the signal-to-noise ratio (SNR), contrast, %coefficient of variation (%CV), SUV, and Likert scale score between ordered-subset expectation maximization (OSEM) time-of-flight (TOF) and OSEM+TOF+PSF in phantom and clinical studies. The conventional image was generated with OSEM+TOF_Gau 6 mm. The National Electrical Manufacturers Association body phantom with 10-mm hot sphere data was acquired for 5 min. Twenty-six patients (40 lesions, ranging from 3.7 to 63.0 mm) were examined using prone breast PET/CT with a breast positioner for breast cancer staging. PET data were acquired 125±9.7 min after intravenous injection of 220±16.1 MBq at 5 min/bed.
Results: In the phantom study, a high SNR was obtained from a 3- to 5-mm Gaussian filter for OSEM+TOF+PSF. The contrast obtained with OSEM+TOF without Gaussian filtering was superior to that obtained with OSEM+TOF+PSF_Gau 4 mm. In the clinical study, the image quality depended on lesion size. The average SNR was significantly higher at 40.8% for lesions >20 mm with OSEM+TOF_Gau 6 mm than with OSEM+TOF without Gaussian filtering. The average contrast for lesions ≤10 mm was significantly higher by 42.0% with OSEM+TOF without Gaussian filtering than with OSEM+TOF_Gau 6 mm. The average SUVmax of OSEM+TOF without Gaussian filtering significantly increased by 53.3% for lesions ≤10 mm.
Conclusion: OSEM+TOF without Gaussian filtering provided good contrast and quantitative value for small lesions.


کلیدواژه‌ها
Breast cancer؛ Digital PET؛ Prone position
مراجع
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