سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Shahidi, Siamak, Soleimani Asl, Sara, Gholamigeravand, Bahareh, Afshar, Simimn, Hashemi-Firouzi, Nasrin, Samzadeh-Kermani, Alireza, Majidi, Mahsa, Amiri, Kimia. (1403). Effect of mesenchymal stem cells and polyvinyl alcohol-coated selenium nanoparticles on rats with Alzheimer-like phenotypes. , 27(10), 1268-1275. doi: 10.22038/ijbms.2024.76242.16495
Siamak Shahidi; Sara Soleimani Asl; Bahareh Gholamigeravand; Simimn Afshar; Nasrin Hashemi-Firouzi; Alireza Samzadeh-Kermani; Mahsa Majidi; Kimia Amiri. "Effect of mesenchymal stem cells and polyvinyl alcohol-coated selenium nanoparticles on rats with Alzheimer-like phenotypes". , 27, 10, 1403, 1268-1275. doi: 10.22038/ijbms.2024.76242.16495
Shahidi, Siamak, Soleimani Asl, Sara, Gholamigeravand, Bahareh, Afshar, Simimn, Hashemi-Firouzi, Nasrin, Samzadeh-Kermani, Alireza, Majidi, Mahsa, Amiri, Kimia. (1403). 'Effect of mesenchymal stem cells and polyvinyl alcohol-coated selenium nanoparticles on rats with Alzheimer-like phenotypes', , 27(10), pp. 1268-1275. doi: 10.22038/ijbms.2024.76242.16495
Shahidi, Siamak, Soleimani Asl, Sara, Gholamigeravand, Bahareh, Afshar, Simimn, Hashemi-Firouzi, Nasrin, Samzadeh-Kermani, Alireza, Majidi, Mahsa, Amiri, Kimia. Effect of mesenchymal stem cells and polyvinyl alcohol-coated selenium nanoparticles on rats with Alzheimer-like phenotypes. , 1403; 27(10): 1268-1275. doi: 10.22038/ijbms.2024.76242.16495

Effect of mesenchymal stem cells and polyvinyl alcohol-coated selenium nanoparticles on rats with Alzheimer-like phenotypes

Iranian Journal of Basic Medical Sciences
مقاله 6، دوره 27، شماره 10، دی 2024، صفحه 1268-1275    اصل مقاله (405.36 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2024.76242.16495
نویسندگان
Siamak Shahidi1؛ Sara Soleimani Asl2؛ Bahareh Gholamigeravand2؛ Simimn Afshar1؛ Nasrin Hashemi-Firouzi* 1؛ Alireza Samzadeh-Kermani3؛ Mahsa Majidi4؛ Kimia Amiri4
1Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
2Department of Anatomy, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
3Department of Chemistry, Faculty of Science, University of Zabol, Zabol, Iran
4School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
چکیده
Objective(s): Mesenchymal stem cell (MSC) transplantation represents a promising approach for treating Alzheimer’s disease (AD). These stem cells, however, have a short lifespan following transplantation into recipient animals. Selenium nanoparticles, due to their size, aid in drug delivery for brain disorders. This study investigated the therapeutic effect of MSCs and polyvinyl alcohol (PVA)-coated selenium nanoparticles (SeNPs) in a rat model of AD.
Materials and Methods: An Alzheimer-like phenotype was induced through intracerebroventricular (ICV) administration of streptozotocin (STZ).  Rats were assigned to five groups: control, Alz (STZ; 3 mg/kg, 10 μl, ICV), Alz+stem cell (ICV transplantation), Alz+SeNP (0.4 mg/kg, orally), and Alz+stem cell+SeNPs. The ICV administration of STZ mimicked some aspects of AD in the Alz groups. SeNPs were administrated for 30 days following STZ administration. The novel object recognition (NOR) and passive avoidance learning (PAL) tests were used to evaluate cognition and memory. Oxidative stress biomarkers and brain-derived neurotrophic factor (BDNF) were assessed by biochemical analysis, ELISA kits, and Congo red staining, respectively. 
Results: The combined therapy of PVA-coated SeNPs and MSC transplantation was more effective in enhancing memory reacquisition compared to either SeNPs or MSCs alone. The use of stem cells in conjunction with PVA-coated SeNPs significantly boosted anti-oxidant capacity.
Conclusion: The results suggest that the joint treatment with PVA-coated SeNPs and MSCs offers considerable neuroprotection against AD in animal models.
کلیدواژه‌ها
Alzheimer disease؛ Memory؛ Polyvinyl alcohol؛ Selenium؛ Stem cells؛ Streptozocin
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