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Abdollahi, Mojdeh, Asle Rousta, Masoumeh, Mahmazi, Sanaz. (1403). Protective effect of 1, 8-cineole (eucalyptol) against lead-induced liver injury by ameliorating oxidative stress and inflammation and modulating TLR4/MyD88/NF-κB signaling. , 27(10), 1293-1299. doi: 10.22038/ijbms.2024.78448.16964
Mojdeh Abdollahi; Masoumeh Asle Rousta; Sanaz Mahmazi. "Protective effect of 1, 8-cineole (eucalyptol) against lead-induced liver injury by ameliorating oxidative stress and inflammation and modulating TLR4/MyD88/NF-κB signaling". , 27, 10, 1403, 1293-1299. doi: 10.22038/ijbms.2024.78448.16964
Abdollahi, Mojdeh, Asle Rousta, Masoumeh, Mahmazi, Sanaz. (1403). 'Protective effect of 1, 8-cineole (eucalyptol) against lead-induced liver injury by ameliorating oxidative stress and inflammation and modulating TLR4/MyD88/NF-κB signaling', , 27(10), pp. 1293-1299. doi: 10.22038/ijbms.2024.78448.16964
Abdollahi, Mojdeh, Asle Rousta, Masoumeh, Mahmazi, Sanaz. Protective effect of 1, 8-cineole (eucalyptol) against lead-induced liver injury by ameliorating oxidative stress and inflammation and modulating TLR4/MyD88/NF-κB signaling. , 1403; 27(10): 1293-1299. doi: 10.22038/ijbms.2024.78448.16964

Protective effect of 1, 8-cineole (eucalyptol) against lead-induced liver injury by ameliorating oxidative stress and inflammation and modulating TLR4/MyD88/NF-κB signaling

Iranian Journal of Basic Medical Sciences
مقاله 9، دوره 27، شماره 10، دی 2024، صفحه 1293-1299    اصل مقاله (595.22 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2024.78448.16964
نویسندگان
Mojdeh Abdollahi1؛ Masoumeh Asle Rousta* 2؛ Sanaz Mahmazi1
1Department of Genetics, Zanjan Branch, Islamic Azad University, Zanjan, Iran
2Department of Physiology, Zanjan Branch, Islamic Azad University, Zanjan, Iran
چکیده
Objective(s): This study was conducted to explore the impact of 1, 8-cineole (eucalyptol) on the biochemical, molecular, and histological changes caused by lead acetate in the liver of adult male Wistar rats. The research also investigated the potential involvement of the TLR4 signaling pathway in this effect. 
Materials and Methods: Rats were orally administered lead acetate (25 mg/kg-day) for 14 consecutive days and received 1, 8-cineole (100 mg/kg-day) during the same period. 
Results: 1, 8-cineole prevented an increase in the malondialdehyde level, a decrease in the glutathione level, and a decrease in the activity of superoxide dismutase and glutathione peroxidase enzymes in the liver of rats treated with lead acetate. This monoterpene also prevented an increase in the expression of pro-inflammatory cytokines and significantly reduced the infiltration of inflammatory cells in the liver parenchyma. Additionally, 1, 8-cineole discouraged the increase in toll-like receptor 4 (TLR4), myeloid differentiation primary response 88 (MyD88), and nuclear factor kappa B (NF-κB) expression in the liver and stopped a rise in serum AST and ALT enzymes. 
Conclusion: 1, 8-cineole can prevent liver damage caused by lead acetate by reducing oxidative stress and inflammation. This hepatoprotection is probably achieved by inhibiting TLR4/MyD88/NF-κB signaling.
کلیدواژه‌ها
Cytokines؛ Eucalyptol؛ Lead acetate؛ Liver؛ Oxidative stress؛ Toll-like receptor 4
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