Prevention of Acute Kidney Injury Related (AKI) related by vancomycin; A Randomized Clinical Trial | ||
| Journal of Patient Safety & Quality Improvement | ||
| مقاله 2، دوره 12، شماره 2، تابستان 2024، صفحه 81-86 اصل مقاله (324.15 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22038/psj.2024.79726.1429 | ||
| نویسندگان | ||
| Mahboubeh Neamatshahi* 1؛ Aghil Keykhosravi2؛ Anoush Azarfar3؛ Yalda Ravanshad4؛ Yosra Mohammadi2؛ Anahita Ataran5؛ Omid Rashidi6؛ Elham Navipour7؛ Homan Tehrani8 | ||
| 1Department of Community Medicine, Faculty of Medicine, Sabzevar University of Medical Sciences, Khorasan Razavi, Iran. | ||
| 2Department of Pediatrics, Faculty of Medicine, Sabzevar University of Medical Sciences, Khorasan Razavi, Iran. | ||
| 3Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. | ||
| 4Department of Community Medicine, Mashhad Branch, Islamic Azad University, Mashhad, Iran. | ||
| 5General Physician, Surgical Oncology Research Center, Mashhad University of Medical Science, Mashhad, Iran. | ||
| 6Student Research Committee, Mashhad University of Medical Science, Mashhad, Iran. | ||
| 7Department of Medical Education, Faculty of Medicine, Shiraz University of Medical Sciences, Iran. | ||
| 8Noncommunicable Disease Research Center, Sabzevar University of Medical Sciences, Subedar, Iran. | ||
| چکیده | ||
| Introduction: Acute kidney injury (AKI) is one of the potential side effects of vancomycin in children with systemic infections. We aimed to evaluate the effect of selenium on the prevention of Vancomycin-associated AKI (VA-AKI) Materials and Methods: This study is a parallel randomized controlled trial in Heshmatieh Hospital, Sabzevar, Iran. According to the simple random sampling method, thirty patients between 1 month and 18 years old with systemic infections were randomly assigned to two groups. The intervention and control groups were treated with vancomycin plus selenium and vancomycin alone, respectively. Urine and blood samples were obtained from patients at the beginning and seven days after the treatment to evaluate AKI among patients. Results: We found no significant difference between baseline BUN, creatinine, and microalbumin in the two groups (P>0.05). There was a significant difference between the two groups post-treatment urine microalbumin (P= 0.045). The frequency of AKI in the intervention group [5(33.3%)] was lower than the control group [11(73.3%)] (P = 0.02). There were few changes between the mean difference baseline and post-treatment Cr (0.1mg/dl) and BUN (2.9mg/dl). Drug efficacy was 66%, and the number needed to treat (NNT) was equal to 2. Conclusion: In the present study, we concluded that selenium could prevent vancomycin-induced AKI. Future investigations on the higher numbers of patients are needed. | ||
| کلیدواژهها | ||
| Acute kidney injury؛ Selenium؛ Vancomycin؛ patient safety | ||
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