سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

خلیلی, عباس. (1403). التهاب گرانولوماتوز در بیماران مبتلا به نقص سیستم ایمنی اولیه. , 67(4), 1262-1274. doi: 10.22038/mjms.2024.77484.4506
عباس خلیلی. "التهاب گرانولوماتوز در بیماران مبتلا به نقص سیستم ایمنی اولیه". , 67, 4, 1403, 1262-1274. doi: 10.22038/mjms.2024.77484.4506
خلیلی, عباس. (1403). 'التهاب گرانولوماتوز در بیماران مبتلا به نقص سیستم ایمنی اولیه', , 67(4), pp. 1262-1274. doi: 10.22038/mjms.2024.77484.4506
خلیلی, عباس. التهاب گرانولوماتوز در بیماران مبتلا به نقص سیستم ایمنی اولیه. , 1403; 67(4): 1262-1274. doi: 10.22038/mjms.2024.77484.4506

التهاب گرانولوماتوز در بیماران مبتلا به نقص سیستم ایمنی اولیه

مجله دانشکده پزشکی دانشگاه علوم پزشکی مشهد
مقاله 5، دوره 67، شماره 4، مهر و آبان 1403، صفحه 1262-1274    اصل مقاله (1.16 M)
نوع مقاله: مقاله مروری
شناسه دیجیتال (DOI): 10.22038/mjms.2024.77484.4506
نویسنده
عباس خلیلی*
گروه آموزشی کودکان دانشگاه علوم پزشکی شهید صدوقی یزد
چکیده
زمینه و هدف: گرانولوم یک واکنش ازدیاد حساسیت تاخیری در پاسخ به عوامل خارجی است که با تجمع سازمان یافته ماکروفاژهای تک هسته ای بالغ ایجاد میشود. گاهی گرانولوم در غیاب یک عامل خارجی تشکیل میشود. لذا علاوه برعوامل عفونی, بیماریهای اتوایمیون و نقایص ایمنی اولیه نیزاز عوامل ایجاد کننده گرانولوم هستند. تعدادی ازنقایص ایمنی اولیه توانایی ایجاد وضعیتهای خود ایمنی والتهابات گرانولوماتوز را دارند. بنابراین علاوه برناخوشیهای ناشی از عفونتهای مکرر, عوارض غیر عفونی نیز این افراد را تهدید میکندکه قطعا در پروگنوز بیماران تاثیربسیار مهمی خواهد داشت. مادر این مقاله مروری قصد داریم بر بیماریهای نقایص ایمنی اولیه همراه با التهاب گرانولوماتوز و تاثیراتی که این ضایعات بر پروگنوز و سیر بیماری دارند را ارزیابی می کنیم.در این مطالعه مروری جستجوی مقالات در پایگاههای اطلاعاتیPubMed, Scopus, Web of science, Google scholar صورت گرفت. در این بررسی تا حد امکان سعی شده از جدیدترین و معتبرترین مقالات به زبان انگلیسی و فارسی که مرتبط با موضوع باشند استفاده شود. مقالات مرتبط ابتدا مورد بررسی قرار گرفتند و پس از ارزیابی ژرنال مربوطه و متدولوژی مقاله بهترین مقالات بعنوان رفرنس انتخاب شدند..

نتیجه‌گیری: تشخیص و درمان به موقع عوارض التهابی که گاهی بروزآنها میتواند قبل از تظاهرات عفونی باشد, دربهبود پروگنوز بیماری موثر است. درمان بیماران با داروهای ایمونوساپرسیو و کورتیکواسترویید ها باید براساس شرایط بیمار, شدت التهاب گرانولوماتوز, وجود عفونت فعال قارچی وباکتریایی صورت گیرد
کلیدواژه‌ها
گرانولوم؛ نقص ایمنی اولیه؛ التهاب گرانولوماتوز؛ خود ایمنی
مراجع
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