سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Takahashi, Kazuya, Ishiguro, Masanobu, Inui, Yoshitaka, Ichihara, Takashi, Shang, Cong, Nagao, Ryunosuke, Mizutani, Yasuaki, Ito, Mizuki, Watanabe, Hirohisa, Motomura, Nobutoku, Toyama, Hiroshi. (1403). Use of the specific binding ratio distribution to characterise multiple system atrophy in advanced iodine-123-labelled N-(3-fluoropropyl)-2β-carbomethoxy-3β-(4-iodophenyl) nortropane serotonin transporter imaging. , 13(1), 33-41. doi: 10.22038/aojnmb.2024.78274.1557
Kazuya Takahashi; Masanobu Ishiguro; Yoshitaka Inui; Takashi Ichihara; Cong Shang; Ryunosuke Nagao; Yasuaki Mizutani; Mizuki Ito; Hirohisa Watanabe; Nobutoku Motomura; Hiroshi Toyama. "Use of the specific binding ratio distribution to characterise multiple system atrophy in advanced iodine-123-labelled N-(3-fluoropropyl)-2β-carbomethoxy-3β-(4-iodophenyl) nortropane serotonin transporter imaging". , 13, 1, 1403, 33-41. doi: 10.22038/aojnmb.2024.78274.1557
Takahashi, Kazuya, Ishiguro, Masanobu, Inui, Yoshitaka, Ichihara, Takashi, Shang, Cong, Nagao, Ryunosuke, Mizutani, Yasuaki, Ito, Mizuki, Watanabe, Hirohisa, Motomura, Nobutoku, Toyama, Hiroshi. (1403). 'Use of the specific binding ratio distribution to characterise multiple system atrophy in advanced iodine-123-labelled N-(3-fluoropropyl)-2β-carbomethoxy-3β-(4-iodophenyl) nortropane serotonin transporter imaging', , 13(1), pp. 33-41. doi: 10.22038/aojnmb.2024.78274.1557
Takahashi, Kazuya, Ishiguro, Masanobu, Inui, Yoshitaka, Ichihara, Takashi, Shang, Cong, Nagao, Ryunosuke, Mizutani, Yasuaki, Ito, Mizuki, Watanabe, Hirohisa, Motomura, Nobutoku, Toyama, Hiroshi. Use of the specific binding ratio distribution to characterise multiple system atrophy in advanced iodine-123-labelled N-(3-fluoropropyl)-2β-carbomethoxy-3β-(4-iodophenyl) nortropane serotonin transporter imaging. , 1403; 13(1): 33-41. doi: 10.22038/aojnmb.2024.78274.1557

Use of the specific binding ratio distribution to characterise multiple system atrophy in advanced iodine-123-labelled N-(3-fluoropropyl)-2β-carbomethoxy-3β-(4-iodophenyl) nortropane serotonin transporter imaging

Asia Oceania Journal of Nuclear Medicine and Biology
مقاله 4، دوره 13، شماره 1، فروردین 2025، صفحه 33-41    اصل مقاله (1.57 M)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/aojnmb.2024.78274.1557
نویسندگان
Kazuya Takahashi* 1؛ Masanobu Ishiguro2؛ Yoshitaka Inui1؛ Takashi Ichihara1؛ Cong Shang1؛ Ryunosuke Nagao3؛ Yasuaki Mizutani4؛ Mizuki Ito3؛ Hirohisa Watanabe4؛ Nobutoku Motomura5؛ Hiroshi Toyama2
1Department of Radiology, Fujita Health University School of Medicine, Aichi, Japan
2Section of Radiology, Fujita Health University Hospital, Aichi, Japan
3Department of Neurology, Fujita Health University
4Department of Neurology, Fujita Health University School of Medicine, Aichi, Japan
5Canon Medical Systems, Otawara, Tochigi, Japan
چکیده
Objective(s): Sudden death in multiple system atrophy (MSA) is caused by decreased serotonergic innervation, but there is no routine test method for this decrease. In addition to dopamine transporters, iodine-123-labelled N-(3-fluoropropyl)-2β-carbomethoxy-3β-(4-iodophenyl) nortropane (123I-FP-CIT) binds serotonin transporters (SERTs). We noted a binding potential to quantify the total quantity of 123I-FP-CIT binding to its receptors.
Following Mintun’s binding-potential concept, this study aimed to evaluate the relationship between the specific binding ratio (SBR) and total SERT tissue amount, but not SERT binding, and to develop an SBR imaging method to measure brain-stem SERT. We sought to establish a binding-potential imaging procedure using SBR images to examine differences in the brain-stem SERT distribution between healthy subjects and MSA patients.
Methods: Single-photon emission computed tomography (SPECT) and T1-weighted magnetic resonance (MR) images were aligned. The MR (T1) images were used to set a reference site for the occipital-lobe SBR in each subject, and measurements were made from the SPECT image at the same position. The pixel values and accumulation ratios compared with the occipital lobe were calculated, and a regional SBR distribution image was created. We identified areas with SERT accumulation above a certain level.
Results: The SERT accumulation site was visualised as an SBR value on MR images. The accumulation distribution (SERT distribution) on the SBR images significantly differed between the healthy subjects and patients with MSA.
Conclusion: SERT accumulation was noted in the brain-stem region, indicating that SBR imaging was useful for viewing and quantifying SERT accumulation.
کلیدواژه‌ها
Serotonin transporter؛ SPECT؛ Binding potential؛ Multiple system atrophy
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