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RODRIGUEZ-MERCHAN, E. Carlos. (1403). Biofilm Related Total Knee Arthroplasty Infection: Prevention, Diagnosis and Treatment. , 12(7), 531-534. doi: 10.22038/abjs.2024.77560.3583
E. Carlos RODRIGUEZ-MERCHAN. "Biofilm Related Total Knee Arthroplasty Infection: Prevention, Diagnosis and Treatment". , 12, 7, 1403, 531-534. doi: 10.22038/abjs.2024.77560.3583
RODRIGUEZ-MERCHAN, E. Carlos. (1403). 'Biofilm Related Total Knee Arthroplasty Infection: Prevention, Diagnosis and Treatment', , 12(7), pp. 531-534. doi: 10.22038/abjs.2024.77560.3583
RODRIGUEZ-MERCHAN, E. Carlos. Biofilm Related Total Knee Arthroplasty Infection: Prevention, Diagnosis and Treatment. , 1403; 12(7): 531-534. doi: 10.22038/abjs.2024.77560.3583

Biofilm Related Total Knee Arthroplasty Infection: Prevention, Diagnosis and Treatment

The Archives of Bone and Joint Surgery
مقاله 10، دوره 12، شماره 7، مهر 2024، صفحه 531-534    اصل مقاله (621.3 K)
نوع مقاله: In Brief
شناسه دیجیتال (DOI): 10.22038/abjs.2024.77560.3583
نویسنده
E. Carlos RODRIGUEZ-MERCHAN*
Department of Orthopaedic Surgery, La Paz University Hospital, Madrid, Spain
چکیده
Biofilm related implant infection is undoubtedly a relevant challenge in total knee arthroplasty (TKA) 
with our comprehension steadily progressing and novel management approaches being developed. The 
aim of this article was to review the most important advances in approaches to combat infections due 
to biofilm-forming bacteria in TKA. The main conclusions were the following: 1) Fundamental 
management techniques for infected TKA include open DAIR (debridement, antibiotics, and implant 
retention), and one and two-stage revision TKA; 2) Continuous local antibiotic perfusion (CLAP) appears 
to diminish the risk of periprosthetic joint infection (PJI); 3) Restraint of quorum sensing seems to avert 
PJI after TKA; 4) A recent in vitro study showed promising results in the prevention and management of 
PJI after TKA using PMMA [poly(methyl methacrylate)] loaded with up to 100 mg of rifampin.
 Level of evidence: III
کلیدواژه‌ها
Biofilms؛ Diagnosis؛ Periprosthetic joint infection؛ Prevention؛ Total knee arthroplasty؛ Treatment
مراجع
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