سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Azhdary Moghadam, Yeganeh, Jafari, Seyed Ali, Shahraki, Touran, Khadem-Rezaiyan, Majid, Basirinezhad, Fatemeh, Imannezhad, Shima, Azhdary Moghaddam, Aida. (1402). Value of Duodenal Bulb Biopsy in the Diagnosis of Celiac Disease in a Group of Iranian Children. , 12(Issue 2), 18563-18572. doi: 10.22038/ijp.2024.77098.5421
Yeganeh Azhdary Moghadam; Seyed Ali Jafari; Touran Shahraki; Majid Khadem-Rezaiyan; Fatemeh Basirinezhad; Shima Imannezhad; Aida Azhdary Moghaddam. "Value of Duodenal Bulb Biopsy in the Diagnosis of Celiac Disease in a Group of Iranian Children". , 12, Issue 2, 1402, 18563-18572. doi: 10.22038/ijp.2024.77098.5421
Azhdary Moghadam, Yeganeh, Jafari, Seyed Ali, Shahraki, Touran, Khadem-Rezaiyan, Majid, Basirinezhad, Fatemeh, Imannezhad, Shima, Azhdary Moghaddam, Aida. (1402). 'Value of Duodenal Bulb Biopsy in the Diagnosis of Celiac Disease in a Group of Iranian Children', , 12(Issue 2), pp. 18563-18572. doi: 10.22038/ijp.2024.77098.5421
Azhdary Moghadam, Yeganeh, Jafari, Seyed Ali, Shahraki, Touran, Khadem-Rezaiyan, Majid, Basirinezhad, Fatemeh, Imannezhad, Shima, Azhdary Moghaddam, Aida. Value of Duodenal Bulb Biopsy in the Diagnosis of Celiac Disease in a Group of Iranian Children. , 1402; 12(Issue 2): 18563-18572. doi: 10.22038/ijp.2024.77098.5421

Value of Duodenal Bulb Biopsy in the Diagnosis of Celiac Disease in a Group of Iranian Children

Journal of Pediatric Perspectives
دوره 12، Issue 2، اردیبهشت 2024، صفحه 18563-18572    اصل مقاله (252.67 K)
نوع مقاله: original article
شناسه دیجیتال (DOI): 10.22038/ijp.2024.77098.5421
نویسندگان
Yeganeh Azhdary Moghadam1؛ Seyed Ali Jafari2؛ Touran Shahraki3؛ Majid Khadem-Rezaiyan4؛ Fatemeh Basirinezhad* 5؛ Shima Imannezhad6؛ Aida Azhdary Moghaddam7
1Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
2Full Professor of Pediatrics Gastroenterology, Department of Pediatrics, School of Medicine, Akbar Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
3Department of Pediatrics, Division of Gastroenterology, Research Center for Children and Adolescent Health Zahedan University of Medical Sciences, Zahedan, Iran.
4Assistant Professor of Community Medicine. Department of Community Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
5Member of clinical research development unit of Akbar hospital, faculty of medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
6Associate professor of pediatric neurology, department of pediatrics, Faculty of medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
7Student Research Committee, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
چکیده
Background: Studies have shown that Celiac Disease (CD) can present with patchy mucosal lesions. The aim of this study is to investigate the utility of duodenal bulb biopsy in the diagnosis of CD in some Iranian children. Moreover, we compare disease characteristics in children with CD consistent histology limited to the duodenal bulb (D1) with those of children with CD-related histology in the second part of duodenum (D2) with or without histology changes in D1.
Methods: This is a cross sectional study on anti-tissue transglutaminase antibody (anti TTG Ab) positive children in Mashhad between 2019 and 2021. Intestinal biopsies from D1 and D2 were done. Diagnosis of CD was defined by the Marsh classification above 1. Patients of 2 groups compared in terms of clinical and laboratory parameters.
Results: from 81 serology positive patients, 70 patients were diagnosed with CD, based on Marsh classification. Among them, 6 patients (8.6%) had exclusive involvement of D1, and 64 cases (91%) had involvement of D2 with or without D1. The two groups did not have a statistically significant difference in terms of clinical presentation, serological and histopathological values.
Conclusion: Taking D1 biopsies can improve case finding of CD in the pediatric population.
کلیدواژه‌ها
Abdominal pain, Celiac disease؛ Child, Short stature, Tissue transglutaminase 2
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آمار
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