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Amini, Sara, Pouladfar, Gholamreza, Ghasemi, Fatemeh, Jafarian, Hadis, Badiee, Parisa. (1403). Evaluation of the Fluconazole Prophylaxis against Fungal Colonization in the Preterm Neonates: A Double-blind Clinical Trial. , 15(2), 13-19. doi: 10.22038/ijn.2024.72428.2403
Sara Amini; Gholamreza Pouladfar; Fatemeh Ghasemi; Hadis Jafarian; Parisa Badiee. "Evaluation of the Fluconazole Prophylaxis against Fungal Colonization in the Preterm Neonates: A Double-blind Clinical Trial". , 15, 2, 1403, 13-19. doi: 10.22038/ijn.2024.72428.2403
Amini, Sara, Pouladfar, Gholamreza, Ghasemi, Fatemeh, Jafarian, Hadis, Badiee, Parisa. (1403). 'Evaluation of the Fluconazole Prophylaxis against Fungal Colonization in the Preterm Neonates: A Double-blind Clinical Trial', , 15(2), pp. 13-19. doi: 10.22038/ijn.2024.72428.2403
Amini, Sara, Pouladfar, Gholamreza, Ghasemi, Fatemeh, Jafarian, Hadis, Badiee, Parisa. Evaluation of the Fluconazole Prophylaxis against Fungal Colonization in the Preterm Neonates: A Double-blind Clinical Trial. , 1403; 15(2): 13-19. doi: 10.22038/ijn.2024.72428.2403

Evaluation of the Fluconazole Prophylaxis against Fungal Colonization in the Preterm Neonates: A Double-blind Clinical Trial

Iranian Journal of Neonatology
دوره 15، شماره 2، تیر 2024، صفحه 13-19    اصل مقاله (436.86 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijn.2024.72428.2403
نویسندگان
Sara Amini1؛ Gholamreza Pouladfar2؛ Fatemeh Ghasemi3؛ Hadis Jafarian3؛ Parisa Badiee* 3
1Department of Pediatrics, Shiraz University of Medical Sciences, Shiraz, Iran
21. Department of Pediatrics, Shiraz University of Medical Sciences, Shiraz, Iran 2. Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
3Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Our study aimed to compare the twice-weekly and three-time weekly prophylactic fluconazole regimens among low birth weight premature neonates.
Methods: Premature neonates (40 cases) were divided into two groups and received two and three-times-weekly fluconazole regimens for three weeks. Surveillance of fungal colonization was performed before treatment and twice weekly.
Results: Fungal colonization occurred in 11 infants in group A and 4 infants in group B (55% vs. 20%, p=0.022). In both groups, the rectum was the most common site of colonization. Candida glabrata, Candida orthopsilosis and, Candida albicans were the most commonly isolated species in both groups. There were no significant differences between the two groups regarding birth weight, gestational age, and other baseline risk factors for fungal colonization.
Conclusion: In this study, the three-times-weekly administration of prophylactic fluconazole appears to be more effective in preventing fungal colonization than the twice-weekly regimen among premature neonates.
 
کلیدواژه‌ها
Candida؛ Fluconazole؛ Neonates
مراجع
  1. Benedict K, Roy M, Kabbani S, Anderson EJ, Farley MM, Harb S, et al. Neonatal and pediatric candidemia: results from population-based active laboratory surveillance in four US locations, 2009–2015. J Pediatric Infect Dis Soc. 2018;7(3):e78-e85.
  2. Lausch KR, Schultz Dungu KH, Callesen MT, Schroder H, Rosthoj S, Poulsen A, et al. Pediatric Candidemia Epidemiology and Morbidities: A Nationwide Cohort. Pediatr Infect Dis J. 2019;38(5):464-469.
  3. Hornik CD, Bondi DS, Greene NM, Cober MP, John B. Review of Fluconazole Treatment and Prophylaxis for Invasive Candidiasis in Neonates. J Pediatr Pharmacol Ther. 2021;26(2):115-122.
  4. Shamsizadeh A, Nikfar R, Mombini M, Keikhaei B, Jafarian H, Badiee P. The Relative Frequency and Susceptibility Patterns of Candida Species Isolated from Blood and Urine of Children with Malignancy. Arch Pediatr Infect Dis. 2018;6(2).
  5. Zhang D, Xie D, He N, Wang X, Dong W, Lei X. Prophylactic use of fluconazole in very premature infants. Front Pediatr. 2021;9:726769.
  6. Anaraki MR, Nouri-Vaskeh M, Oskoei SA. Fluconazole prophylaxis against invasive candidiasis in very low and extremely low birth weight preterm neonates: a systematic review and meta-analysis. Clin Exp Pediatr. 2021;64(4):172-179.
  7. Mesini A, Saffioti C, Mariani M, Florio A, Medici C, Moscatelli A, et al. First Case of Candida auris Colonization in a Preterm, Extremely Low-Birth-Weight Newborn after Vaginal Delivery. J Fungi (Basel). 2021;7(8):649.
  8. Agarwal RR, Agarwal RL, Chen X, Lua JL, Ang JY. Epidemiology of invasive fungal infections at two tertiary care neonatal intensive care units over a 12-year period (2000-2011). Glob Pediatr Health. 2017;4:2333794X17696684. 
  9. Kaufman D, Boyle R, Hazen KC, Patrie JT, Robinson M, Donowitz LG. Fluconazole prophylaxis against fungal colonization and infection in preterm infants. N Engl J Med. 2001;345(23):1660-1666.
  10. Manzoni P, Arisio R, Mostert M, Leonessa M, Farina D, Latino MA, et al. Prophylactic fluconazole is effective in preventing fungal colonization and fungal systemic infections in preterm neonates: a single-center, 6-year, retrospective cohort study. 2006;117(1):e22-32.
  11. Leonart LP, Tonin FS, Ferreira VL, Tavares da Silva Penteado S, de Araujo Motta F, Pontarolo R. Fluconazole Doses Used for Prophylaxis of Invasive Fungal Infection in Neonatal Intensive Care Units: A Network Meta-Analysis. J Pediatr. 2017;185:129-135.e6.
  12. Schoeni MH, Martin RJ, Avroy A. Fanaroff and Michele C. Walsh, Neonatal-Perinatal Medicine: Diseases of the Fetus and Infant—10th Edition: Saunders, an imprint of Elsevier. Inc., 2015, ISBN: 978-1-4557-5617-9. Eur J Pediatr. 2015; 174:1699-700.
  13. Hope WW, Castagnola E, Groll AH, Roilides E, Akova M, Arendrup MC, et al. ESCMID* guideline for the diagnosis and management of Candida diseases 2012: prevention and management of invasive infections in neonates and children caused by Candida spp. Clin Microbiol Infect. 2012;18 Suppl 7:38-52.
  14. Mirhendi H, Makimura K, Khoramizadeh M, Yamaguchi H. A one-enzyme PCR-RFLP assay for identification of six medically important Candida species. Nihon Ishinkin Gakkai Zasshi. 2006;47(3):225-229.
  15. Ericson JE, Kaufman DA, Kicklighter SD, Bhatia J, Testoni D, Gao J, et al. Fluconazole prophylaxis for the prevention of candidiasis in premature infants: A meta-analysis using patient-level data. Clin Infect Dis. 2016;63:604-6
  16. Hsu JF, Lai MY, Lee CW, Chu SM, Wu IH, Huang HR, et al. Comparison of the incidence, clinical features and outcomes of invasive candidiasis in children and neonates. BMC Infect Dis. 2018;18(1):194.
  17. Manzoni P, Stolfi I, Pugni L, Decembrino L, Magnani C, Vetrano G, et al. A multicenter, randomized trial of prophylactic fluconazole in preterm neonates. N Engl J Med. 2007;356:2483-24
  18. Kaufman DA, Gurka MJ, Hazen KC, Boyle R, Robinson M, Grossman LB. Patterns of fungal colonization in preterm infants weighing less than 1000 grams at birth. J Pediatric Infect Dis Soc. 2006;25(8):733-73
  19. Rios J, Camargos PAM, Correa LP, Romanelli RMC. Fluconazole prophylaxis in preterm infants: a systematic review. Braz J Infect Dis. 2017;21(3):333-338.
  20. Weitkamp JH, Ozdas A, LaFleur B, Potts AL. Fluconazole prophylaxis for prevention of invasive fungal infections in targeted highest risk preterm infants limits drug exposure. J Perinatol. 2008;28(6):405-411.
  21. Turner K, Manzoni P, Benjamin DK, Cohen-Wolkowiez M, Smith PB, Laughon MM. Fluconazole pharmacokinetics and safety in premature infants. Curr Med Chem. 2012;19(27):4617-4620.
  22. Saiman L, Ludington E, Dawson JD, Patterson JE, Rangel-Frausto S, Wiblin RT, et al. Risk factors for Candida species colonization of neonatal intensive care unit patients. Pediatr Infect Dis J. 2001;20(12):1119-1124.
  23. Rezaei M, Moghtaderi M, Badiee P, Zahadatpoor Z, Pooladfar G. Fungal colonization among iranian infants hospitalized in the neonatal intensive care unit: occurrence rate, risk factors and health outcome. Int J Pediatr. 2019;7(7):9719-97
  24. Ali GY, Algohary EHSS, Rashed KA, Almoghanum M, Khalifa AA. Prevalence of Candida colonization in preterm newborns and VLBW in neonatal intensive care unit: role of maternal colonization as a risk factor in transmission of disease. J Matern Fetal Neonatal Med. 2012;25(6):789-795.
  25. Badiee P, Badali H, Diba K, Jafarian H, Mohammadi R, Mirhendi H, et al. Multicenter identification and antifungal susceptibility patterns of candida species isolated from clinical samples. Jundishapur J Microbiol. 2017;10(12):e56117.
 

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