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Noersjafrudin, Ivory, Hanum, Ulfi, Marufah, Asmaul, Putranto, Aloysius, Endarko, Endarko. (1403). Influence of Normal Tissue Objective Tools on Treatment Planning System in Nasopharyngeal Carcinoma (NPC): A 3D Printed Anthropomorphic Phantom Study. , 21(6), 409-417. doi: 10.22038/ijmp.2024.76906.2352
Ivory Rasyida Noersjafrudin; Ulfi Qomariyah Hanum; Asmaul Lutfi Marufah; Aloysius Mario Yudi Putranto; Endarko Endarko. "Influence of Normal Tissue Objective Tools on Treatment Planning System in Nasopharyngeal Carcinoma (NPC): A 3D Printed Anthropomorphic Phantom Study". , 21, 6, 1403, 409-417. doi: 10.22038/ijmp.2024.76906.2352
Noersjafrudin, Ivory, Hanum, Ulfi, Marufah, Asmaul, Putranto, Aloysius, Endarko, Endarko. (1403). 'Influence of Normal Tissue Objective Tools on Treatment Planning System in Nasopharyngeal Carcinoma (NPC): A 3D Printed Anthropomorphic Phantom Study', , 21(6), pp. 409-417. doi: 10.22038/ijmp.2024.76906.2352
Noersjafrudin, Ivory, Hanum, Ulfi, Marufah, Asmaul, Putranto, Aloysius, Endarko, Endarko. Influence of Normal Tissue Objective Tools on Treatment Planning System in Nasopharyngeal Carcinoma (NPC): A 3D Printed Anthropomorphic Phantom Study. , 1403; 21(6): 409-417. doi: 10.22038/ijmp.2024.76906.2352

Influence of Normal Tissue Objective Tools on Treatment Planning System in Nasopharyngeal Carcinoma (NPC): A 3D Printed Anthropomorphic Phantom Study

Iranian Journal of Medical Physics
دوره 21، شماره 6، بهمن و اسفند 2024، صفحه 409-417    اصل مقاله (1.82 M)
نوع مقاله: Original Paper
شناسه دیجیتال (DOI): 10.22038/ijmp.2024.76906.2352
نویسندگان
Ivory Rasyida Noersjafrudin1؛ Ulfi Qomariyah Hanum1؛ Asmaul Lutfi Marufah1؛ Aloysius Mario Yudi Putranto2؛ Endarko Endarko* 3
1Department of Physics, Institut Teknologi Sepuluh Nopember, Kampus ITS Sukolilo, Surabaya 60111, East Java, Indonesia
2Department of Radiation Oncology, Mochtar Riady Comprehensive Cancer Center (MRCCC) Siloam Hospital Semanggi, Jakarta, 12930, Indonesia
3Department of Physics, Institut Teknologi Sepuluh Nopember, Kampus ITS Sukolilo – Surabaya 60111, East Java, Indonesia
چکیده
Introduction: The normal tissue objective (NTO), one of the new aspects in the radiation treatment planning system (TPS), aims to lower the absorbed dose received by organs at risk (OARs) close to the target volume or Planning Target Volume (PTV). This study was conducted to ascertain the impact of planning in nasopharyngeal cancer (NPC) cases both with and without manual NTO settings.
Material and Methods: The study used a 3D printed head and neck phantom exposed to radiation using the Intensity Modulated Radiation Therapy (IMRT) technique with 6000 cGy prescribed dose and divided into 30 fractions to find the discrepancies between the manually calculated absorbed dose­ and the automatic calculated absorbed dose of TPS. Moreover, evaluation parameter indicators, including the homogeneity index (HI), conformity index (CI), gradient index (GI), and comprehensive quality index (CQI), were used to make comparisons. NTO parameter used in manual plans are f0 = 107%, f∞ = 65%, dose fall-off  = 0.05 mm-1, and xstart = 0.75 cm.
Results: The statistical analysis resulted in a significant difference between the calculated absorbed dose and TPS's absorbed dose of Automatic NTO and Manual NTO, whereas, Without NTO plans, there was no statistical difference. The HI values for Automatic NTO, Manual NTO, and Without NTO are 0.118, 0.05 , and 0.053, respectively. The CI values for Automatic NTO, Manual NTO, and Without NTO are 0.91, 0.99, and 0,19. The GI value for Automatic NTO, Manual NTO, and Without NTO are 3.34, 4.94, and 7.29, respectively. CQI parameter showed that the Automatic NTO plan performs better than the Manual NTO plan based on the maximum dose received by the OAR.
Conclusion: In this study, the manual NTO plan showed better performance by reducing hot spots in the central region of PTV.
کلیدواژه‌ها
Evaluation Index Parameters؛ IMRT؛ Normal Tissue Objective (NTO)؛ Treatment Planning System
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