سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Meftahi, Gholam Hossein, Khodadadi, Mohsen, Pirzad Jahromi, Gila, Ezami Razliqi, Masoud, Valipour, Habib. (1403). Crocin nano-chitosan-coated compound improves anxiety disorders, learning, and spatial memory in Alzheimer’s model induced by beta-amyloid in rats. , 27(7), 879-887. doi: 10.22038/ijbms.2024.74823.16247
Gholam Hossein Meftahi; Mohsen Khodadadi; Gila Pirzad Jahromi; Masoud Ezami Razliqi; Habib Valipour. "Crocin nano-chitosan-coated compound improves anxiety disorders, learning, and spatial memory in Alzheimer’s model induced by beta-amyloid in rats". , 27, 7, 1403, 879-887. doi: 10.22038/ijbms.2024.74823.16247
Meftahi, Gholam Hossein, Khodadadi, Mohsen, Pirzad Jahromi, Gila, Ezami Razliqi, Masoud, Valipour, Habib. (1403). 'Crocin nano-chitosan-coated compound improves anxiety disorders, learning, and spatial memory in Alzheimer’s model induced by beta-amyloid in rats', , 27(7), pp. 879-887. doi: 10.22038/ijbms.2024.74823.16247
Meftahi, Gholam Hossein, Khodadadi, Mohsen, Pirzad Jahromi, Gila, Ezami Razliqi, Masoud, Valipour, Habib. Crocin nano-chitosan-coated compound improves anxiety disorders, learning, and spatial memory in Alzheimer’s model induced by beta-amyloid in rats. , 1403; 27(7): 879-887. doi: 10.22038/ijbms.2024.74823.16247

Crocin nano-chitosan-coated compound improves anxiety disorders, learning, and spatial memory in Alzheimer’s model induced by beta-amyloid in rats

Iranian Journal of Basic Medical Sciences
مقاله 11، دوره 27، شماره 7، مهر 2024، صفحه 879-887    اصل مقاله (1.03 M)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2024.74823.16247
نویسندگان
Gholam Hossein Meftahi1؛ Mohsen Khodadadi1؛ Gila Pirzad Jahromi* 1؛ Masoud Ezami Razliqi2؛ Habib Valipour1
1Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
2Applied Virology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
چکیده
Objective(s): Alzheimer’s disease (AD) is a neurodegenerative disease that results in the gradual breakdown of brain tissue, causing the deterioration of intellectual function and ability. Crocin is a saffron carotenoid compound proven to have excellent neuroprotective and anti-inflammation properties, although it has some limitations such as low stability and bioavailability. Therefore, in the current research, we tried to improve these limitations by using nanotechnology and chitosan as the carrier. Our study examined the therapeutic effects of crocin nano-chitosan-coated compound and compared it with intact crocin in lower dosages than other studies in AD rat models. 
Materials and Methods: Encapsulating crocin into chitosan nanoparticles was done through a modified technique to improve its limitations. The AD rat model was induced by bilaterally injecting beta-amyloid (Aβ) peptide into the frontal lobe using a stereotaxic device. To evaluate memory, we conducted the Barnes maze test, and to evaluate anxiety, we used the elevated plus maze test. Also, histological tests were conducted to evaluate neuronal damage in each group. 
Results: Crocin nano-chitosan-coated administration significantly improved specific memory indicators compared to the Aβ and other treated groups. A significant decrease in anxiety indicators was detected compared to the Aβ and other treated groups. Finally, the results of hippocampus staining indicated a meaningful difference between the Aβ group and other treated groups, compared to the crocin nano-chitosan-coated group. 
Conclusion: Treatment with low dosages of crocin in the nano-coated form exhibited great efficacy in reducing AD’s adverse effects compared to the same dosage of intact crocin.
کلیدواژه‌ها
Amyloid-beta؛ Anxiety؛ Chitosan؛ Crocin؛ Hippocampus؛ Memory؛ Nanoparticle
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