Watanabe, Yuya, Hosokawa, Syota, Takahashi, Yasuyuki. (1403). Time-of-flight PET/CT suppresses CT based attenuation correction and scatter coincidence correction errors due to misalignment of the gastrointestinal tract. , 12(2), 131-141. doi: 10.22038/aojnmb.2024.74406.1520
Yuya Watanabe; Syota Hosokawa; Yasuyuki Takahashi. "Time-of-flight PET/CT suppresses CT based attenuation correction and scatter coincidence correction errors due to misalignment of the gastrointestinal tract". , 12, 2, 1403, 131-141. doi: 10.22038/aojnmb.2024.74406.1520
Watanabe, Yuya, Hosokawa, Syota, Takahashi, Yasuyuki. (1403). 'Time-of-flight PET/CT suppresses CT based attenuation correction and scatter coincidence correction errors due to misalignment of the gastrointestinal tract', , 12(2), pp. 131-141. doi: 10.22038/aojnmb.2024.74406.1520
Watanabe, Yuya, Hosokawa, Syota, Takahashi, Yasuyuki. Time-of-flight PET/CT suppresses CT based attenuation correction and scatter coincidence correction errors due to misalignment of the gastrointestinal tract. , 1403; 12(2): 131-141. doi: 10.22038/aojnmb.2024.74406.1520

Time-of-flight PET/CT suppresses CT based attenuation correction and scatter coincidence correction errors due to misalignment of the gastrointestinal tract

Asia Oceania Journal of Nuclear Medicine and Biology
مقاله 4، دوره 12، شماره 2، مهر 2024، صفحه 131-141    اصل مقاله (1.76 M)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/aojnmb.2024.74406.1520
نویسندگان
Yuya Watanabe* ؛ Syota Hosokawa؛ Yasuyuki Takahashi
Hirosaki University Graduate School of Health Sciences, Hirosaki-shi, Aomori, Japan
چکیده
Objective(s): This study aimed to examine the influence of changes in CT values on PET images, specifically focusing on errors in CT-based attenuation correction and scatter coincidence correction (CTAC/SC) caused by gastrointestinal gas. Furthermore, it aimed to demonstrate the effectiveness of time-of-flight (TOF) PET in reducing CTAC/SC errors.
Methods: PET images were reconstructed using multiple CT images with varying CT values. The study then compared the fluctuations in pixel values of the PET images corresponding to the different CT values utilized for CTAC/SC between non-TOF and TOF acquisitions.
Results: PET pixel values fluctuated with changes in CT values. In the phantom study, TOF showed a significantly smaller change in PET pixel value of 1.00±0.27 kBq/mL compared to 3.72±1.33 kBq/mL in the non-TOF at sites with a CT change of +1000 HU. In the patient study, a linear regression analysis was performed to determine the effect of changes in CT values due to gastrointestinal gas migration on standard uptake value (SUV).The results showed that the TOF group had a lower ratio of change in SUV to change in CT values compared to the non-TOF group. These findings revealed that PET pixel values exhibited fluctuations in response to changes in CT values, and TOF-PET effectively mitigated CTAC/SC errors arising from gastrointestinal gas.
Conclusions: TOF-PET has the potential to reduce the occurrence of suspicious accumulation.
کلیدواژه‌ها
Time-of-flight technique؛ Positron emission tomography؛ Computed Tomography-based correction error
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