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Shahramian, Iraj, Jahanpanah, Anita, Tahani, Masoud, Shahramiyan, Zahra, Delaram Nasab, Mojtaba, Arefi, Mahdie. (1402). Epigenetics of Early Inflammatory Bowel Disease among Children: A Systematic Review. , 12(Issue 2), 18530-18546. doi: 10.22038/ijp.2024.77198.5416
Iraj Shahramian; Anita Jahanpanah; Masoud Tahani; Zahra Shahramiyan; Mojtaba Delaram Nasab; Mahdie Arefi. "Epigenetics of Early Inflammatory Bowel Disease among Children: A Systematic Review". , 12, Issue 2, 1402, 18530-18546. doi: 10.22038/ijp.2024.77198.5416
Shahramian, Iraj, Jahanpanah, Anita, Tahani, Masoud, Shahramiyan, Zahra, Delaram Nasab, Mojtaba, Arefi, Mahdie. (1402). 'Epigenetics of Early Inflammatory Bowel Disease among Children: A Systematic Review', , 12(Issue 2), pp. 18530-18546. doi: 10.22038/ijp.2024.77198.5416
Shahramian, Iraj, Jahanpanah, Anita, Tahani, Masoud, Shahramiyan, Zahra, Delaram Nasab, Mojtaba, Arefi, Mahdie. Epigenetics of Early Inflammatory Bowel Disease among Children: A Systematic Review. , 1402; 12(Issue 2): 18530-18546. doi: 10.22038/ijp.2024.77198.5416

Epigenetics of Early Inflammatory Bowel Disease among Children: A Systematic Review

International Journal of Pediatrics
دوره 12، Issue 2، اردیبهشت 2024، صفحه 18530-18546    اصل مقاله (359.02 K)
نوع مقاله: systematic review
شناسه دیجیتال (DOI): 10.22038/ijp.2024.77198.5416
نویسندگان
Iraj Shahramian1؛ Anita Jahanpanah2؛ Masoud Tahani3؛ Zahra Shahramiyan4؛ Mojtaba Delaram Nasab3؛ Mahdie Arefi* 5
1Gastroenterohepatology Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
2Student research committee, Faculty of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran.
3Pediatric Gastroenterology and Hepatology Research Center, Zabol University of Medical Sciences, Zabol, Iran
4Pediatric Gastroenterology and Hepatology Research Center, Zabol University of Medical Sciences, Zabol, Iran.
5Pediatric Gastroenterology and Hepatology Research Center, zabol University of Medical Science, Zabol, Iran.
چکیده
Background: Inflammatory bowel diseases (IBDs) are complex and multifaceted disorders characterized by recurrent and persistent intestinal inflammation. The incidence of inflammatory bowel disease (IBD) is on the rise among both children and adults worldwide. In this review, we provide an update on genomic studies of IBD, with a particular focus on Very Early-Onset IBD (VEO-IBD), which often presents with a more severe phenotype than IBD at an older age.
Methods: The methods used in this systematic review were performed according to the guidelines of the PRISMA checklist. A search was conducted by two independent researchers in international databases (PubMed, Web of Science, Scopus, and Google Scholar) to find relevant studies published in English.
Results: Patients with VEO-IBD have rare or novel genes associated with immunodeficiency that may play a role in the pathogenesis of the disease. To date, ten regions for 240 genes, which are usually monogenic, have been identified for this disease, mostly due to mutations. But the most important cause of VEO-IBD is mutation in interleukin 10. It has also been reported that VEO-IBD is associated with increased expression of S100A8 and S100A9 genes in rectal mucosa and serum.
Conclusion: Considering the multifactorial nature of IBD, all the changes that cause protein expression and function should be taken into account; so for early diagnosis and timely treatment of this disease, more extensive phenotypic sequencing is needed to discover new gene loci. And these children can be treated with hematopoietic stem cell transplantation, as the most efficient method.
کلیدواژه‌ها
Keywords: genetics؛ Crohn' s disease؛ ulcerative colitis؛ early inflammatory disease
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