Parvizi, Mahdieh, Abbasi, Mehrshad, Ahmadzadehfar, Hojjat, Tafakhori, Abbas, Naseri, Maryam, Khalaj, Ali, Farzanehfar, Saeed. (1403). Bio-distribution study of Tc-99m HMPAO labeled platelet in healthy volunteer. , 12(2), 142-148. doi: 10.22038/aojnmb.2024.71620.1525
Mahdieh Parvizi; Mehrshad Abbasi; Hojjat Ahmadzadehfar; Abbas Tafakhori; Maryam Naseri; Ali Khalaj; Saeed Farzanehfar. "Bio-distribution study of Tc-99m HMPAO labeled platelet in healthy volunteer". , 12, 2, 1403, 142-148. doi: 10.22038/aojnmb.2024.71620.1525
Parvizi, Mahdieh, Abbasi, Mehrshad, Ahmadzadehfar, Hojjat, Tafakhori, Abbas, Naseri, Maryam, Khalaj, Ali, Farzanehfar, Saeed. (1403). 'Bio-distribution study of Tc-99m HMPAO labeled platelet in healthy volunteer', , 12(2), pp. 142-148. doi: 10.22038/aojnmb.2024.71620.1525
Parvizi, Mahdieh, Abbasi, Mehrshad, Ahmadzadehfar, Hojjat, Tafakhori, Abbas, Naseri, Maryam, Khalaj, Ali, Farzanehfar, Saeed. Bio-distribution study of Tc-99m HMPAO labeled platelet in healthy volunteer. , 1403; 12(2): 142-148. doi: 10.22038/aojnmb.2024.71620.1525

Bio-distribution study of Tc-99m HMPAO labeled platelet in healthy volunteer

Asia Oceania Journal of Nuclear Medicine and Biology
مقاله 5، دوره 12، شماره 2، مهر 2024، صفحه 142-148    اصل مقاله (1.15 M)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/aojnmb.2024.71620.1525
نویسندگان
Mahdieh Parvizi1؛ Mehrshad Abbasi2؛ Hojjat Ahmadzadehfar3؛ Abbas Tafakhori4؛ Maryam Naseri2؛ Ali Khalaj5؛ Saeed Farzanehfar* 2
1Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
2Department of Nuclear Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
3Department of Nuclear Medicine, University Hospital Bonn, Bonn, Germany
4Department of Neurology, School of Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
5Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
چکیده
Objective(s): The bio-distribution of Tc-99m HMPAO labeled platelets (LP), which could be used to image subtle thrombosis, is not reported in a human yet, which is the subject of the current study.
Method: The platelets were extracted from 49 ml whole blood and labeled with Tc-99m HMPAO, then re-injected to the healthy volunteer. Anterior and posterior whole body imaging was done by a dual-head gamma camera 3, 18, 33, 46, 81, 124, 190 min and 15 hours after injection. Also a whole-body SPECT was done at 137 min post-injection. The area under the curves of the spleen, liver, left kidney, bladder, right lung, brain, and abdominal aorta ROIs was calculated to estimate the accumulation of labeled platelets within the organs.
Results: The spleen was the target organ. The kidneys, liver, and heart were also remarkably visualized. The thyroid, stomach, bladder, or gastrointestinal (GI) uptake/activity was not significant. The stomach visualization was enhanced after ingestion at 60 min. The sagittal and lateral sinuses were delineated, and the background of the brain was very low. During the study, the area under the curve of activity was 738, 308, 302, 196, 230, 121, 79, 216, 529, 369, 162, and 54 counts. min/pixel for spleen, liver, heart, right lung, left kidney, right iliac artery, sagittal sinus, thyroid, bladder, stomach, GI, and background, respectively.
Conclusion: The quality of the scan with low dose Tc-99m HMPAO LPs is optimal. We documented the bio-distribution of LPs. The optimal imaging time was 80-120 min post-injection when the free Tc-99m and GI transit were negligible. The sagittal and lateral sinuses were visualized enabling detection of possible clots in the vessels.
کلیدواژه‌ها
Tc-99m-HMPAO labeled platelets scan؛ Human bio-distribution study؛ Sagittal sinus؛ lateral sinus
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