سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Nazemi, Seyedeh Sahar, Jomezadeh, Vahid, Khademi, Gholamreza, Rahsepar, Sara, Hajzadeh, Ghodsieh, Naseri, Maryam, Bahramizadeh, Mahdiyeh, Abedi, Farshad, Sezavar, Majid, Mohamadpour, AmirHoushang. (1402). The Effect of Pentoxifylline on the Prevention of ARDS in PICU Patients: A Randomized Double-Blind Clinical Trial. , 12(1), 18517-18529. doi: 10.22038/ijp.2024.72502.5274
Seyedeh Sahar Nazemi; Vahid Jomezadeh; Gholamreza Khademi; Sara Rahsepar; Ghodsieh Hajzadeh; Maryam Naseri; Mahdiyeh Bahramizadeh; Farshad Abedi; Majid Sezavar; AmirHoushang Mohamadpour. "The Effect of Pentoxifylline on the Prevention of ARDS in PICU Patients: A Randomized Double-Blind Clinical Trial". , 12, 1, 1402, 18517-18529. doi: 10.22038/ijp.2024.72502.5274
Nazemi, Seyedeh Sahar, Jomezadeh, Vahid, Khademi, Gholamreza, Rahsepar, Sara, Hajzadeh, Ghodsieh, Naseri, Maryam, Bahramizadeh, Mahdiyeh, Abedi, Farshad, Sezavar, Majid, Mohamadpour, AmirHoushang. (1402). 'The Effect of Pentoxifylline on the Prevention of ARDS in PICU Patients: A Randomized Double-Blind Clinical Trial', , 12(1), pp. 18517-18529. doi: 10.22038/ijp.2024.72502.5274
Nazemi, Seyedeh Sahar, Jomezadeh, Vahid, Khademi, Gholamreza, Rahsepar, Sara, Hajzadeh, Ghodsieh, Naseri, Maryam, Bahramizadeh, Mahdiyeh, Abedi, Farshad, Sezavar, Majid, Mohamadpour, AmirHoushang. The Effect of Pentoxifylline on the Prevention of ARDS in PICU Patients: A Randomized Double-Blind Clinical Trial. , 1402; 12(1): 18517-18529. doi: 10.22038/ijp.2024.72502.5274

The Effect of Pentoxifylline on the Prevention of ARDS in PICU Patients: A Randomized Double-Blind Clinical Trial

Journal of Pediatric Perspectives
دوره 12، شماره 1، فروردین 2024، صفحه 18517-18529    اصل مقاله (462.93 K)
نوع مقاله: review article
شناسه دیجیتال (DOI): 10.22038/ijp.2024.72502.5274
نویسندگان
Seyedeh Sahar Nazemi1؛ Vahid Jomezadeh2؛ Gholamreza Khademi3، 4، 5؛ Sara Rahsepar1؛ Ghodsieh Hajzadeh3؛ Maryam Naseri3؛ Mahdiyeh Bahramizadeh1؛ Farshad Abedi1؛ Majid Sezavar* 3، 4؛ AmirHoushang Mohamadpour* 1، 6
1Department of Clinical pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
2Department of Surgery, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
3Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
4Clinical Research Development Unit of Akbar Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
5Neonatal Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
6Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
چکیده
Background: Inflammation has a remarkable role in Acute Respiratory Distress Syndrome (ARDS) pathophysiology. Pentoxifylline is a phosphodiesterase IV inhibitor with anti-inflammatory and anti-thrombotic properties, which has had positive results in rodents with ARDS. Due to the lack of human studies, we designed this clinical trial to evaluate the pentoxifylline effect on ARDS prevention in high-risk pediatric patients.
Methods: We included thirty-four children from Akbar hospital’s pediatric intensive care unit (PICU). These patients were highly susceptible to ARDS progression. Using a randomized, double-blind method, 17 patients received pentoxifylline tablets three times a day for a week, while others received placebo tablets at the same interval for seven days. Lung Injury Prediction Score (LIPS), vital signs, pulse oximetry, PaO2, pH, and PaCO2 were measured at baseline and every day for a week period. CRP was assessed at baseline, then on the third and seventh days. Finally, we imported all the data to SPSS software to compare the treatment and placebo groups.
Results: Each placebo and treatment group had seventeen patients who had no statistically significant difference in baseline demographic information or lab data. The variations in LIPS score (P=0.475), CRP (P=0.053), pH (P=0.199), PO2 (P=0.077), PCO2 (P=0.528), Heart rate (P=0.086), Respiratory rate (P=0.512), Diastolic blood pressure (P=0.572), Systolic blood pressure (P=0.517), and SPO2 (P=0.260) were compared between the two groups; and no significant difference was observed.
Conclusion: The results of this clinical trial suggest that pentoxifylline had no prophylactic effect on pediatric ARDS, but for confirmation, further clinical trials with different designs and larger sample sizes are required.
کلیدواژه‌ها
ARDS؛ Pediatric ICU؛ Pentoxifylline؛ RCT
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