سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Elbakry, Noura, Fadle, Yossra, Ahmed, Ayat, Farhan, Sara, kotb, Dalia, Mahmoud, Nagwa. (1402). Sars-cov-2 Infection Is a Potential Risk of Diabetic Ketoacidosis in Children Diagnosed with Type i Diabetes. An Observational Study. , 12(1), 18449-18460. doi: 10.22038/ijp.2024.76289.5394
Noura M. Ibrahim Elbakry; Yossra Samir Fadle; Ayat Mostafa Mohamed Ahmed; Sara Mahmoud Farhan; Dalia Nabil kotb; Nagwa Mohamed Sabry Mahmoud. "Sars-cov-2 Infection Is a Potential Risk of Diabetic Ketoacidosis in Children Diagnosed with Type i Diabetes. An Observational Study". , 12, 1, 1402, 18449-18460. doi: 10.22038/ijp.2024.76289.5394
Elbakry, Noura, Fadle, Yossra, Ahmed, Ayat, Farhan, Sara, kotb, Dalia, Mahmoud, Nagwa. (1402). 'Sars-cov-2 Infection Is a Potential Risk of Diabetic Ketoacidosis in Children Diagnosed with Type i Diabetes. An Observational Study', , 12(1), pp. 18449-18460. doi: 10.22038/ijp.2024.76289.5394
Elbakry, Noura, Fadle, Yossra, Ahmed, Ayat, Farhan, Sara, kotb, Dalia, Mahmoud, Nagwa. Sars-cov-2 Infection Is a Potential Risk of Diabetic Ketoacidosis in Children Diagnosed with Type i Diabetes. An Observational Study. , 1402; 12(1): 18449-18460. doi: 10.22038/ijp.2024.76289.5394

Sars-cov-2 Infection Is a Potential Risk of Diabetic Ketoacidosis in Children Diagnosed with Type i Diabetes. An Observational Study

Journal of Pediatric Perspectives
دوره 12، شماره 1، فروردین 2024، صفحه 18449-18460    اصل مقاله (233.28 K)
نوع مقاله: original article
شناسه دیجیتال (DOI): 10.22038/ijp.2024.76289.5394
نویسندگان
Noura M. Ibrahim Elbakry1؛ Yossra Samir Fadle1؛ Ayat Mostafa Mohamed Ahmed2؛ Sara Mahmoud Farhan3؛ Dalia Nabil kotb4؛ Nagwa Mohamed Sabry Mahmoud* 1
1Pediatric Department, Faculty of Medicine, Minia University, Egypt.
2Clinical pathology department, Faculty of Medicine, Minia University, Egypt.
3Microbiology and immunology department, faculty of pharmacy, Deraya University, Egypt.
4Medical Microbiology and Immunology Department, Faculty of Medicine, Minia University, Egypt.
چکیده
Background: Since the beginning of COVID-19 pandemic, several studies have reported increased type 1 diabetes (T1D) and severe diabetic ketoacidosis (DKA) in children. Recent studies have linked viruses to T1D due to their autoimmune nature. SARS-CoV-2 infection may cause hyperglycemia and DKA. In this study we aimed to evaluate the incidence of DKA in pediatric patients with T1D during the initial COVID-19 pandemic and the years preceding it.
Methods: The present study is a retrospective observational investigation conducted at Minia University Hospital's Pediatric Intensive Care Unit (PICU). Children diagnosed with T1D who recently had SARS-CoV-2, as validated by laboratory testing with the RT-PCR method, were included in the study. The cases referred to during the period from March 2020 to February 2022, which coincided with the pandemic, were compared with those newly diagnosed with diabetes and presented with DKA from March 2018 to February 2020, the pre-pandemic phase. Comparisons were made on the incidence, frequency, and diagnostic criteria.
Results: During the pandemic period, we admitted 212 cases of new‐onset T1D. Of these, 159 (75%) patients had DKA, and 53 (25%) had hyperglycemia. Comparing the pre-pandemic with the pandemic period, we noted that the number of children identified with T1D had risen from 4.99/100,000children per year in pre-pandemic periods to 8.46 /100 000 PY in the pandemic period with an incidence rate ratio (IRR) of 6.25 (95% CI 2.90 to 7.83); p<0.0001.
Conclusion: COVID-19 pandemic has caused a rise in the number of children with newly diagnosed diabetes, and more people with newly diagnosed diabetes are now presenting with severe DKA.
کلیدواژه‌ها
COVID-19؛ diabetic ketoacidosis؛ diabetes mellitus؛ SARS-CoV-2
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