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Farhat, Ahmad Shah, Kabiri, Mona, Khodashenas, Ezzat, Birjandi, Hassan, Alinejad, Samira. (1402). Evaluating the Effect of Prophylactic Acetaminophen in the Prevention of Patent Ductus Arteriosus (PDA) in Premature Neonates: A randomized clinical trial. , 11(12), 18424-18432. doi: 10.22038/ijp.2023.76250.5393
Ahmad Shah Farhat; Mona Kabiri; Ezzat Khodashenas; Hassan Birjandi; Samira Alinejad. "Evaluating the Effect of Prophylactic Acetaminophen in the Prevention of Patent Ductus Arteriosus (PDA) in Premature Neonates: A randomized clinical trial". , 11, 12, 1402, 18424-18432. doi: 10.22038/ijp.2023.76250.5393
Farhat, Ahmad Shah, Kabiri, Mona, Khodashenas, Ezzat, Birjandi, Hassan, Alinejad, Samira. (1402). 'Evaluating the Effect of Prophylactic Acetaminophen in the Prevention of Patent Ductus Arteriosus (PDA) in Premature Neonates: A randomized clinical trial', , 11(12), pp. 18424-18432. doi: 10.22038/ijp.2023.76250.5393
Farhat, Ahmad Shah, Kabiri, Mona, Khodashenas, Ezzat, Birjandi, Hassan, Alinejad, Samira. Evaluating the Effect of Prophylactic Acetaminophen in the Prevention of Patent Ductus Arteriosus (PDA) in Premature Neonates: A randomized clinical trial. , 1402; 11(12): 18424-18432. doi: 10.22038/ijp.2023.76250.5393

Evaluating the Effect of Prophylactic Acetaminophen in the Prevention of Patent Ductus Arteriosus (PDA) in Premature Neonates: A randomized clinical trial

International Journal of Pediatrics
دوره 11، شماره 12، اسفند 2023، صفحه 18424-18432    اصل مقاله (218.4 K)
نوع مقاله: original article
شناسه دیجیتال (DOI): 10.22038/ijp.2023.76250.5393
نویسندگان
Ahmad Shah Farhat1؛ Mona Kabiri2؛ Ezzat Khodashenas3؛ Hassan Birjandi4؛ Samira Alinejad* 5
1Assistant Professor of Neonatology, Neonatal Research Center, Medical Faculty, Mashhad University of Medical Sciences, Mashhad Iran.
2Clinical Research Development unit, Ghaem hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad Iran
3Neonatal Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad Iran.
4Pediatric Interventional Cardiologist, Pediatric and Congenital Cardiology Division, Pediatric Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad Iran.
5Subspecialist Assistant of Neonatology, Neonatal Research Center, Faculty of Medicine, Mashhad university of medical sciences, Mashhad Iran
چکیده
neonates. The purpose of this study is to determine the efficacy of prophylactic parenteral acetaminophen as a safer alternative drug for PDA in preterm infants.
Methods: In a randomized clinical trial carried out in a one-year period, 60 preterm newborns under 30 weeks of gestational age with birth weights under 1500 grams, admitted in neonatal intensive care unit (NICU) of Emam Reza Hospital, Mashhad were studied. The prophylaxis group received parenteral acetaminophen for 3 days. Echocardiography was performed 96 hours after the last given dose and on the 14th day in both groups.
Result: There were 30 newborns in each group. In the 4th-day echocardiography, in 33.3% of the prophylaxis group and 26.7% of the control group, the ductus arteriosus was closed (P=0.106). In the 14th-day echocardiography, the ductus was closed in 63% and 41.4% of the intervention and control group, respectively, which was not statistically significant. In addition there was not a significant difference in the ratio of left atrium to aortic root between the two groups.
Conclusion: This study showed that in total, PDA was closed in more cases in the intervention group compared to the control group but the difference was not statistically significant. Acetaminophen is a new medicine for PDA closure, which may be more prevalent in future due to its cost effectiveness and safety.
کلیدواژه‌ها
paracetamol,,؛ ,،prophylaxis,,؛ ,،ductus arteriosus,,؛ ,،newborns
مراجع
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